2024
DOI: 10.1021/acsnano.4c09254
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A Supramolecular Self-Assembled Nanoprodrug for Enhanced Ferroptosis Therapy

Zhengwei Yu,
Xin Xie,
Qing Li
et al.

Abstract: Ferroptosis can induce cell death that leverages Fe 2+ -triggered Fenton reactions within living organisms, leading to an excessive accumulation of lipid peroxides (LPOs) and inducing cell death. Ferroptosis can effectively circumvent the inevitable drug resistance encountered with traditional apoptotic therapies. However, several issues remain in the clinical application of ferroptosis anticancer therapy, primarily due to the poor efficiency of intracellular Fenton reaction. To address this issue, we develope… Show more

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