A Surface–Regional and Freeze–Thaw Characterization of the Porcine Temporomandibular Joint Disc

Allen, Kyle D.; Athanasiou, Kyriacos A.

doi:10.1007/s10439-005-3872-6

Cited by 61 publications

(64 citation statements)

References 41 publications

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“…During the test, 10% step strains were applied from 10% up to 30% strain, with 10-minute intervals between steps for stress relaxation. We obtained values for instantaneous modulus, relaxation modulus, and coefficient of viscosity by fitting data to a viscoelastic solution for a Kelvin solid (Allen and Athanasiou, 2005).…”

Section: Compression Sample Preparation and Testing Proceduresmentioning

confidence: 99%

An Interspecies Comparison of the Temporomandibular Joint Disc

et al. 2010

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A supplemental appendix to this article is published electronically only at http://jdr.sagepub.com/Appendix. ABSTRACTThe temporomandibular joint (TMJ) disc plays a critical role in normal function of the joint, and many disorders of the TMJ are a result of disc dysfunction. Previous quantitative TMJ characterization studies examined either the human or a specific animal model, but no single study has compared different species, in the belief that differences in joint morphology, function, and diet would be reflected in the material properties of the disc. In this study, we examined topographical biochemical (collagen, glycosaminoglycan, and DNA content) and biomechanical (tensile and compressive) properties of the human TMJ disc, and also discs from the cow, goat, pig, and rabbit. Regional and interspecies variations were identified in all parameters measured, and certain disc characteristics were observed across all species, such as a weak intermediate zone under mediolateral tension. While human discs possessed properties distinct from those of the other species, pig discs were most similar to the human, suggesting that the pig may be a suitable animal model for TMJ bioengineering efforts.

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Section: Compression Sample Preparation and Testing Proceduresmentioning

confidence: 99%

An Interspecies Comparison of the Temporomandibular Joint Disc

et al. 2010

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“…29 However, another study found that five cycles of freeze and thaw after two initial cycles did not significantly alter either viscoelastic behavior or compressive properties of the temporomandibular joint (TMJ) disk. 30 Strong similarities exist between the TMJ disk and the meniscus regarding the relative amount ($80% dry weight) and primary collagen type (Type I), organization of collagen fibers (primarily circumferential), and the relative amount ($3%-5% dry weight) and type of glycosaminoglycans (primarily chondrotin sulfate). 31 Similar to the TMJ disk, multiple freeze-thaw cycles likely had little effect on meniscal compressive properties.…”

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confidence: 99%

Compressive moduli of the human medial meniscus in the axial and radial directions at equilibrium and at a physiological strain rate

Chia

Hull

2008

Journal Orthopaedic Research

177

145

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The axial and radial compressive moduli of the human meniscus are important material properties in tibiofemoral joint models, but they have not been determined previously for fresh-frozen tissue. Our goals were to measure the moduli at equilibrium and at a physiological strain rate, to determine whether the axial and radial compressive moduli are equal for each type of loading, and to determine whether they depend on the region (i.e., anterior, middle, posterior) of the meniscus. Samples from each region from 10 fresh-frozen human medial menisci were tested in unconfined compression at four strain levels (3%, 6%, 9%, and 12%) at 32%/s, a strain rate determined to be physiologically relevant to walking, and then allowed to reach equilibrium in stress relaxation. At equilibrium, the axial and radial compressive moduli at 12% strain were 83.4 kPa and 76.1 kPa, respectively (p ¼ 0.58), whereas at the physiological strain rate, the axial and radial compressive moduli at 12% strain were 718 kPa and 605 kPa, respectively (p ¼ 0.61). At the physiological strain rate, the modulus increased with increasing strain (79.2 kPa at 3% strain vs. 662 kPa at 12% strain) and the modulus in the anterior region (1,048 kPa at 12% strain) was significantly greater than that in the posterior region (329 kPa at 12% strain) (p ¼ 0.04). Our study supports a plane of isotropy for the material properties of meniscal tissue. However, the material behavior is strongly nonlinear because the compressive modulus is several orders of magnitude smaller than previously reported values for tensile modulus. Further, the compressive modulus depends on the activity of interest (i.e., static such as standing or dynamic such as walking) due to viscoelastic effects, the strain level, and the region of the tissue. ß

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“…55,56 Instead, it is now shown that a highly complex and integrated relationship appears to exist that connects not only overall matrix composition, but also its architecture with the functionality of both native and engineered cartilaginous tissues. 34,38,40,[57][58][59] Gaining a better understanding of the intricate relationship between structure and function in engineered tissues should be the focus of future studies to aid in advancing tissue engineering endeavors.…”

Section: Discussionmentioning

confidence: 99%

Passive Strain-Induced Matrix Synthesis and Organization in Shape-Specific, Cartilaginous Neotissues

MacBarb

Paschos

Abeug

et al. 2014

Tissue Engineering Part A

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Tissue-engineered musculoskeletal soft tissues typically lack the appropriate mechanical robustness of their native counterparts, hindering their clinical applicability. With structure and function being intimately linked, efforts to capture the anatomical shape and matrix organization of native tissues are imperative to engineer functionally robust and anisotropic tissues capable of withstanding the biomechanically complex in vivo joint environment. The present study sought to tailor the use of passive axial compressive loading to drive matrix synthesis and reorganization within self-assembled, shape-specific fibrocartilaginous constructs, with the goal of developing functionally anisotropic neotissues. Specifically, shape-specific fibrocartilaginous neotissues were subjected to 0, 0.01, 0.05, or 0.1 N axial loads early during tissue culture. Results found the 0.1-N load to significantly increase both collagen and glycosaminoglycan synthesis by 27% and 67%, respectively, and to concurrently reorganize the matrix by promoting greater matrix alignment, compaction, and collagen crosslinking compared with all other loading levels. These structural enhancements translated into improved functional properties, with the 0.1-N load significantly increasing both the relaxation modulus and Young's modulus by 96% and 255%, respectively, over controls. Finite element analysis further revealed the 0.1-N uniaxial load to induce multiaxial tensile and compressive strain gradients within the shape-specific neotissues, with maxima of 10.1%, 18.3%, and -21.8% in the XX-, YY-, and ZZ-directions, respectively. This indicates that strains created in different directions in response to a single axis load drove the observed anisotropic functional properties. Together, results of this study suggest that strain thresholds exist within each axis to promote matrix synthesis, alignment, and compaction within the shape-specific neotissues. Tailoring of passive axial loading, thus, presents as a simple, yet effective way to drive in vitro matrix development in shape-specific neotissues toward more closely achieving native structural and functional properties.

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A Surface–Regional and Freeze–Thaw Characterization of the Porcine Temporomandibular Joint Disc

Cited by 61 publications

References 41 publications

An Interspecies Comparison of the Temporomandibular Joint Disc

An Interspecies Comparison of the Temporomandibular Joint Disc

Compressive moduli of the human medial meniscus in the axial and radial directions at equilibrium and at a physiological strain rate

Passive Strain-Induced Matrix Synthesis and Organization in Shape-Specific, Cartilaginous Neotissues

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