A surfactant-mediated sol-gel method for the preparation of molecularly imprinted polymers and its application in a biomimetic immunoassay for the detection of protein

Chen, Guoning; Shu, Hua; Wang, Lu; Hu, Qianqian; Cui, Xia; Zhu, Hongcheng; Luo, Zhimin; Chang, Chun; Fu, Qiang

doi:10.1016/j.jpba.2020.113511

Cited by 23 publications

(12 citation statements)

References 39 publications

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“…The sol-gel method is one of the most common methods for the preparation of molecularly imprinted polymers due to its intrinsic conversion efficiency and material homogeneity at the molecular level, high solvent, and thermal stability, and one-step preparation process (Beqqali et al, 2017;Guoning et al, 2020). The most common sol-gel method uses methyl orthosilicate (TMOS) or ethyl orthosilicate (TEOS) as a precursor to introduce the imprinted template into the inorganic network structure, which is homogeneously mixed in the solution state and subjected to hydrolysis and condensation chemistry to form highly stable chemically-reacted crosslinked polymers (Dai et al, 2014;Figueiredo et al, 2016;Barsbay and Güven, 2018).…”

Section: Sol-gel Methodsmentioning

confidence: 99%

“…In order to obtain functionally diverse molecularly imprinted polymer materials, in this section we focus on the modification of polymer materials by introducing different chemical substances to thereby achieve detection and adsorption effects. Guoning et al (2020) designed a surfactant-mediated sol-gel system to construct imprinted polymer layers for the preparation of protein MIPs (Figure 5), in which 3-(methacryloxy) propyltrimethoxysilane (MPS) was used as a cross-linker monomer and solvent-containing surfactant was used as a mild hydrolysis system. In this reaction system, a homogeneous solution was obtained, avoiding the disruption of protein structure in the organic solvent environment.…”

Section: Sol-gel Methodsmentioning

confidence: 99%

“…The principle and procedure for the preparation of MIPs(Guoning et al, 2020). Reprinted with permission from Elsevier.…”

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confidence: 99%

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Recent Advances and Future Trends in the Detection of Contaminants by Molecularly Imprinted Polymers in Food Samples

Gao

Chen

et al. 2020

Front. Chem.

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Drug residues, organic dyes, heavy metals, and other chemical pollutants not only cause environmental pollution, but also have a serious impact on food safety. Timely and systematic summary of the latest scientific advances is of great importance for the development of new detection technologies. In particular, molecularly imprinted polymers (MIPs) can mimic antibodies, enzymes and other biological molecules to recognize, enrich, and separate contaminants, with specific recognition, selective adsorption, high affinity, and strong resistance characteristics. Therefore, MIPs have been widely used in chemical analysis, sensing, and material adsorption. In this review, we first describe the basic principles and production processes of molecularly imprinted polymers. Secondly, an overview of recent applications of molecularly imprinted polymers in sample pre-treatment, sensors, chromatographic separation, and mimetic enzymes is highlighted. Finally, a brief assessment of current technical issues and future trends in molecularly imprinted polymers is also presented.

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Section: Sol-gel Methodsmentioning

confidence: 99%

Section: Sol-gel Methodsmentioning

confidence: 99%

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Recent Advances and Future Trends in the Detection of Contaminants by Molecularly Imprinted Polymers in Food Samples

Gao

Chen

et al. 2020

Front. Chem.

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“…Other examples of MIPs for assay applications are the production of a MIP through sol-gel polymerization on the surface of microplates using recombinant human erythropoietin-α (rhEPO) as a template molecule [ 141 ], and the surfactant-mediated sol-gel polymerization in an aqueous environment designed in order to get MIPs for protein recognition [ 142 ]. Furthermore, new possibilities emerged using magnetic MIPs in microplates [ 143 ].…”

Section: Molecularly Imprinted Polymers (Mips)mentioning

confidence: 99%

The Evolution of Molecular Recognition: From Antibodies to Molecularly Imprinted Polymers (MIPs) as Artificial Counterpart

Parisi

Francomano

Dattilo

et al. 2022

JFB

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Molecular recognition is a useful property shared by various molecules, such as antibodies, aptamers and molecularly imprinted polymers (MIPs). It allows these molecules to be potentially involved in many applications including biological and pharmaceutical research, diagnostics, theranostics, therapy and drug delivery. Antibodies, naturally produced by plasma cells, have been exploited for this purpose, but they present noticeable drawbacks, above all production cost and time. Therefore, several research studies for similar applications have been carried out about MIPs and the main studies are reported in this review. MIPs, indeed, are more versatile and cost-effective than conventional antibodies, but the lack of toxicity studies and their scarce use for practical applications, make it that further investigations on this kind of molecules need to be conducted.

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“…Many target samples for mycotoxin detection are aqueous, including those for environmental, food and therapeutic diagnoses [ 59 , 62 , 63 ]. Free radical and non-free radical polymerisation methods were developed to synthesise aqueous MIPs that avoid the occurrence of heterogeneous binding sites [ 61 ].…”

Section: Conventional and Advanced Analytical Technologiesmentioning

confidence: 99%

Recent Advances in Conventional Methods and Electrochemical Aptasensors for Mycotoxin Detection

Ong

Pike

Tan

2021

Foods

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The presence of mycotoxins in foodstuffs and feedstuffs is a serious concern for human health. The detection of mycotoxins is therefore necessary as a preventive action to avoid the harmful contamination of foodstuffs and animal feed. In comparison with the considerable expense of treating contaminated foodstuffs, early detection is a cost-effective way to ensure food safety. The high affinity of bio-recognition molecules to mycotoxins has led to the development of affinity columns for sample pre-treatment and the development of biosensors for the quantitative analysis of mycotoxins. Aptamers are a very attractive class of biological receptors that are currently in great demand for the development of new biosensors. In this review, the improvement in the materials and methodology, and the working principles and performance of both conventional and recently developed methods are discussed. The key features and applications of the fundamental recognition elements, such as antibodies and aptamers are addressed. Recent advances in aptasensors that are based on different electrochemical (EC) transducers are reviewed in detail, especially from the perspective of the diagnostic mechanism; in addition, a brief introduction of some commercially available mycotoxin detection kits is provided.

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A surfactant-mediated sol-gel method for the preparation of molecularly imprinted polymers and its application in a biomimetic immunoassay for the detection of protein

Cited by 23 publications

References 39 publications

Recent Advances and Future Trends in the Detection of Contaminants by Molecularly Imprinted Polymers in Food Samples

Recent Advances and Future Trends in the Detection of Contaminants by Molecularly Imprinted Polymers in Food Samples

The Evolution of Molecular Recognition: From Antibodies to Molecularly Imprinted Polymers (MIPs) as Artificial Counterpart

Recent Advances in Conventional Methods and Electrochemical Aptasensors for Mycotoxin Detection

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