A Surgical Approach to the Implantation of an Artificial Lung

La, Trudell; Ec, Peirce; Teplitz, Carl; Pd, Richardson; Pm, Galletti

doi:10.1097/00002480-197902500-00089

Cited by 9 publications

(4 citation statements)

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“…Furthermore, by making the implant pseudoexternalized, we would need only to couple up with the vessels from the heart to the lung and could avoid trying to connect also to the natural airways for gas supply. As we reported at ASAIO in 1979, 34 regarding the phases up to implantation, the results with 14 animals provided some encouragement and identified some problems. One of the latter was compression of the long (typically 25 cm) ePTFE graft we had placed between the stumps of the pulmonary artery and pulmonary vein to allow flow and provide lengths of patent graft if needed in the implantation stage, and the production and accumulation of sebaceous material in the thoracic cavity by the skin derived from the split thickness and meshed graft.…”

Section: The Experimental Studiesmentioning

confidence: 76%

The Artificial Lung Facility at Brown: More Than a Dozen Years With Pierre Galletti

Richardson

2005

ASAIO Journal

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Beginning in 1969, Pierre Galletti and his colleagues established a laboratory at Brown University, which, initially and for many years, was involved with artificial lungs. Various projects budded out of this, including the following: the establishment of standards for oxygenator performance, which anticipated Food and Drug Administration requirements; studies of thrombosis and other pathologies, which could be reduced by design changes; long-term, pumpless arterio-venous (A-V) bypass; early hybrid pancreas and other artificial organs; implantable lungs; and spin off companies. The current report outlines the history, philosophy, collaborations, and major results of the laboratory, as well as how the principal investigators simultaneously moved into research areas outside of artificial lungs in the late 1980s.

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Section: The Experimental Studiesmentioning

confidence: 76%

The Artificial Lung Facility at Brown: More Than a Dozen Years With Pierre Galletti

Richardson

2005

ASAIO Journal

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“…For example, besides being entirely intravascular, such as the IVOX, the blood flow path could be from the right ventricle/pulmonary artery to the left atrium or from the RV/PA to the distal pulmonary artery. The majority of devices were constructed to be implanted after pneumonectomy and perfused with right ventricular blood with the direction of flow proceeding from the RV to the left atrium (10)(11)(12)(13)(14)(15). This was accomplished with or without a right ventricular assist device (21).…”

Section: Fl Fazzalari Et Almentioning

confidence: 99%

An Intrapleural Lung Prosthesis: Rationale, Design, and Testing

et al. 1994

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Extracorporeal life support (ECLS or ECMO) is standard treatment for severe respiratory failure but poses many contraindications to future lung transplantation. The solution to this dilemma is the implantable gas exchange device (IGED) or artificial lung. Preliminary efforts to create such an artificial lung have been made since 1970 and include designs involving single devices, intravascular devices (i.e., IVOX), and combination heart-lung devices. Stringent requirements govern the design of such a device, the most important of which are high gas exchange efficiency, low resistance to blood flow, and size. This paper describes such a device. It incorporates large diameter inflow and outflow ports in close proximity and a low resistance wound hollow fiber core encapsulated in a compliant outer shell which conserves the work of the right ventricle. In a large animal model (adult sheep) this device was connected in line with the main pulmonary artery in series with the native lungs. This configuration has the advantages of using the lungs as an embolic filter, perfusing the lungs with fully oxygenated blood, and maintaining the integrity of the anatomy necessary for transplant. Laboratory experiments have run > 8 h. Preliminary data show that the animals have remained hemodynamically stable while the devices have supported the animals completely by supplying 100% O2 saturation with PO2 values ranging from 250-350 mm Hg. Additionally, this model makes possible the study of respiratory failure without introducing other variables such as extracorporeal circuits or pumps. The other metabolic, endocrine, and reticuloendothelial functions of normal and injured lungs can now be studied more precisely by excluding these variables.(ABSTRACT TRUNCATED AT 250 WORDS)

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“…The lobes were partially enclosed with soft vinyl plastic bags and ventilated through tubes attached to portions of the bags. The experiments INTRACORPOREAL were essentially acute (17). The skin grafts, even when they "took" well, usually failed to cover 100% of the inner thoracic cavity, probably because of the difficulties of working in such a confined space (access between ribs) and reaching the furthest corners of the thoracic cavity especially the apex.…”

Section: Work On Designs For Intracorporeal Blood Oxygenators At Browmentioning

confidence: 99%

Intracorporeal Oxygenation

Richardson

1994

Artificial Organs

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The dominant problem in the design of an intracorporeal oxygenator is achieving gas transfer rates sufficient for physiological needs in the space available with acceptably low flow resistance to blood. Design problems still to be solved, when configurations with sufficient gas transfer effectiveness are well identified, are biological tolerance (including adequate blood compatibility), ease of manufacture, and prolonged function.

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A Surgical Approach to the Implantation of an Artificial Lung

Cited by 9 publications

References 0 publications

The Artificial Lung Facility at Brown: More Than a Dozen Years With Pierre Galletti

The Artificial Lung Facility at Brown: More Than a Dozen Years With Pierre Galletti

An Intrapleural Lung Prosthesis: Rationale, Design, and Testing

Intracorporeal Oxygenation

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