A Survey about Irritable Bowel Syndrome in South Korea

Park, Kyung Sik; Ahn, Sung Hun; Hwang, Jae Seok; Cho, Kwang Bum; Chung, Woo Jin; Jang, Byoung Kuk; Kang, Yu Na; Kwon, Jung Hyeok; Kim, Young Hwan

doi:10.1007/s10620-007-9930-1

Cited by 39 publications

(21 citation statements)

References 51 publications

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“…In our previous study, conducted in 42 IBS patients diagnosed by the Rome Ⅱ criteria, the microscopic findings of mucosal hyperplasia, lymphocyte aggregation, and increased eosinophil counts were more frequently observed in the IBS group than the control group. Microscopic colitis does not appear to be associated with IBS symptoms [62] . A study in Malaysia also identified microscopic inflammations in D-IBS subjects that did not meet the criteria for classical microscopic colitis.…”

Section: Inflammationmentioning

confidence: 81%

Irritable bowel syndrome: Emerging paradigm in pathophysiology

Lee

Park

2014

WJG

136

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Irritable bowel syndrome (IBS) is one of the most common gastrointestinal disorders, characterized by abdominal pain, bloating, and changes in bowel habits. These symptoms cannot be explained by structural abnormalities and there is no specific laboratory test or biomarker for IBS. Therefore, IBS is classified as a functional disorder with diagnosis dependent on the history taking about manifested symptoms and careful physical examination. Although a great deal of research has been carried out in this area, the pathophysiology of IBS is complex and not completely understood. Multiple factors are thought to contribute to the symptoms in IBS patients; altered gastrointestinal motility, visceral hypersensitivity, and the brain-gut interaction are important classical concepts in IBS pathophysiology. New areas of research in this arena include inflammation, postinfectious low-grade inflammation, genetic and immunologic factors, an altered microbiota, dietary factors, and enteroendocrine cells. These emerging studies have not shown consistent results, provoking controversy in the IBS field. However, certain lines of evidence suggest that these mechanisms are important at least a subset of IBS patients, confirming that IBS symptoms cannot be explained by a single etiological mechanism. Therefore, it is important to keep in mind that IBS requires a more holistic approach to determining effective treatment and understanding the underlying mechanisms.

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Section: Inflammationmentioning

confidence: 81%

Irritable bowel syndrome: Emerging paradigm in pathophysiology

Lee

Park

2014

WJG

136

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“…Many studies have assessed that the overall prevalence of IBS as up to approximately 25% using the Manning and the Rome criteria worldwide 12,21,22. To date, the prevalence of IBS in Korea using the Rome II criteria has been estimated as ranging from 6.6% to 16.8% 23,24. Many studies about diagnostic criteria for IBS have been performed since the publication of the Rome III criteria.…”

Section: Introductionmentioning

confidence: 99%

“…Many studies about diagnostic criteria for IBS have been performed since the publication of the Rome III criteria. However, there are few studies regarding the prevalence of IBS diagnosed by the Rome II criteria in Asian countries,23,24 and the Rome III criteria have only recently been published to diagnose and classify IBS. Moreover, only a few studies have compared the Rome II and III criteria for IBS, worldwide 8,18…”

Section: Introductionmentioning

confidence: 99%

The Differences in Prevalence and Sociodemographic Characteristics of Irritable Bowel Syndrome According to Rome II and Rome III

Park

Lee²,

Shim

et al. 2010

J Neurogastroenterol Motil

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Background/AimsIrritable bowel syndrome (IBS) is one of the most frequently observed disorders by primary care and practitioners. The aim of this study was to estimate the prevalence of IBS using the Rome II and III criteria in the general Korean population and also to compare sociodemographic differences between subjects diagnosed by these criteria.MethodsTelephone interview surveys were performed with a total of 1,009 individuals in Korea, 15 years of age or older. The questionnaire, based on the Rome II and III criteria, was validated.ResultsAmong the 1,009 subjects, the prevalence of IBS was 8.0% under the Rome II criteria (81 subjects; 6.4%, male; 9.6%, female), and 9.0% (91 subjects; 7.0%, male; 11.0%, female) under the Rome III criteria. The accordance rate of Rome II and III was 73.5%. Both groups showed highest frequency in the age of 30s (13.9% vs. 15.3% respectively). Female subjects showed a higher prevalence than male subjects under Rome III (91 subjects; 11.0% in female, 7.0% in male; p < 0.05), but not under Rome II criteria. Many patients older than 50 years were added when analyzed under the Rome III criteria, but not under the Rome II criteria (p = 0.017).ConclusionsThe Rome III criteria were less restrictive and showed good agreement with the Rome II criteria. The prevalence of IBS was increased in young women.

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“…In United States, IBS is known as the most common gastrointestinal disease and comprises 25 to 50% of all referrals to gastroenterologists,1 and the prevalence of IBS has estimated to range 9% to 22% of the population 2. In Korea, Park et al3 reported the prevalence of IBS increased up to 16.8%. A few effective medicines such as cisapride, tegaserod and alosetron have been withdrawn from the market because of their serious adverse drug reactions.…”

Section: Introductionmentioning

confidence: 99%

Effect of Probiotics on Symptoms in Korean Adults with Irritable Bowel Syndrome

Hong

Kang

et al. 2009

Gut Liver

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Background/AimsIrritable bowel syndrome (IBS) is a troublesome disease. Some strains of probiotics reportedly exert remarkable immunomodulatory effects, and so we designed a prospective double-blind randomized placebo-controlled clinical study to assess their effects in Korean adults with IBS.MethodsIBS patients who met Rome III criteria were randomly assigned to receive composite probiotics or placebo. A total of 20 billion lyophilized bacteria were administered twice daily for 8 weeks. Primary outcome variables were symptom scores consisting of abdominal pain, flatulence, defecation discomfort, and sum of symptom scores. A visual analogue scale was used to quantify the severity. Secondary outcome variables consisted of the quality of life and bowel habits including defecation frequency and stool form.ResultsThirty-six and 34 patients were randomized to the probiotics and placebo groups, respectively. Intention-to-treat analysis showed significant reductions in pain after 8 weeks of treatment: -31.9 and -17.7 in the probiotics and placebo groups, respectively (p=0.045). The reductions in abdominal pain, defecation discomfort, and sum of scores were more significant in 58 patients with a score of at least 3 on the baseline stool-form scale.ConclusionsComposite probiotics containing Bifidobacterium bifidum BGN4, Lactobacillus acidophilus AD031, and other species are safe and effective, especially in patients who excrete normal or loose stools.

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A Survey about Irritable Bowel Syndrome in South Korea

Cited by 39 publications

References 51 publications

Irritable bowel syndrome: Emerging paradigm in pathophysiology

Irritable bowel syndrome: Emerging paradigm in pathophysiology

The Differences in Prevalence and Sociodemographic Characteristics of Irritable Bowel Syndrome According to Rome II and Rome III

Effect of Probiotics on Symptoms in Korean Adults with Irritable Bowel Syndrome

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