A Survey-Based Analysis of Symptoms in Patients with Postural Orthostatic Tachycardia Syndrome

Deb, Anindita; Morgenshtern, Karen; Culbertson, Collin; Wang, Liz B.; Hohler, Anna DePold

doi:10.1080/08998280.2015.11929217

Cited by 48 publications

(42 citation statements)

References 22 publications

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“…Other symptoms are fatigue, exercise intolerance, hyperventilation, dyspnea and anxiety. An overview of all possible symptoms, adopted from previous publications [6][7][8], is illustrated (Figure1A). As the symptoms exacerbate by simple activities of daily life, such as eating or exercise [2][3][4], the impact of PoTS is debilitating.…”

Section: Discussionmentioning

confidence: 99%

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Postural Tachycardia Syndrome

Saïd¹

2017

IJCC

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Section: Discussionmentioning

confidence: 99%

“…PoTS may be included in the differential diagnosis of palpitation, presyncope, shortness of breath and lightheadedness. Tilt Figure 1A: An intake list used for assessment of symptoms in suspected PoTS patients, adopted from [6][7][8]. Intake list regarding the symptoms of PoTS, filled in by the patient.…”

Section: Discussionmentioning

confidence: 99%

Postural Tachycardia Syndrome

Saïd¹

2017

IJCC

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“…Common symptoms include chronic fatigue and pain, as well as diminished quality of life 1–3. POTS is a heterogeneous disorder,4 and includes symptoms such as neuropathic pain,1 poor sleep efficiency,5 headaches, palpitations, tremors, gastrointestinal disturbance, facial flushing,6 and orthostatic symptoms like dizziness, lightheadedness, and syncope 7. Many people have developed POTS after a viral infection, surgery, motor vehicle accident, concussion, or during pregnancy 8,9…”

Section: Introductionmentioning

confidence: 99%

“…Many with POTS report sleep disruption at night,6,10–12 including poor sleep efficiency and increased sleep fragmentation 5. Activation of the sympathetic nervous system may explain sleep disruption in some POTS patients,5,13 while sleep disruption could also be due to chronic pain and hyperarousal 11,14.…”

Section: Introductionmentioning

confidence: 99%

Sleep disturbance linked to suicidal ideation in postural orthostatic tachycardia syndrome

Pederson

Brook

2017

NSS

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ObjectiveWe investigated the prevalence of suicidal ideation in relationship with symptoms of sleep disruption in people with postural orthostatic tachycardia syndrome (POTS).MethodsOnline surveys (including the Pittsburgh Sleep Quality Index and the Suicide Behaviors Questionnaire – Revised) were completed by 705 POTS patients and 170 non-POTS controls.ResultsPoor sleep quality was reported in 98.4% of POTS patients with a calculated subjective sleep efficiency of 65.4%. The POTS group’s sleep efficiency was significantly lower (t[873]= −11.32; p<0.001) and sleep disturbances because of pain were significantly higher (t[873]=15.36; p<0.001) than controls. Chi-square testing showed a larger proportion of individuals at high-risk for suicide among POTS patients than controls (c2 [1, n=875]=55.6; p<0.001). Multiple linear regression analysis showed that sleep scores (β=0.23, p<0.001), age (β=–0.03, p<0.001), and illness with POTS (β=0.68, p=0.05) were significantly associated with suicide ideation scores (F[4, 870]=38.34, p<0.001). This model explained 15% of variance (R2=0.15) in suicidal ideation scores.ConclusionPatients with POTS may suffer from increased sleep disturbance and suicidal ideation compared with the general population. Treatment to improve sleep efficiency and sleep quality is an important step toward better quality of life for POTS patients.

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“…It is characterized by a variety of associated symptoms such as palpitations and facial flushing. Increased circulating catecholamine levels and hyperadrenergism are possible underlying pathophysiological mechanisms 4. Orthostatic and non-orthostatic symptoms coexist.…”

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confidence: 99%