A survey of antifungal compounds from higher plants, 1982–1993

Grayer, Renée J.; Harborne, Jeffrey B.

doi:10.1016/0031-9422(94)85005-4

Cited by 452 publications

(231 citation statements)

References 161 publications

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“…Normally, antifungal compounds are classified either by their taxonomic distribution or chemical structures. Diterpenoids, including both M A and M B , of which many isolated compounds from higher plants, have been reported to exert strong fungicidal activity (Grayer & Harborne 1994). For example, the diterpene pisiferic acid from leaves and twigs of Chamaecyparis pisifera (Cupressaceae) displayed strong antifungal activity against the rice pathogen Pyricularia oryzae (Kobayashi et al 1987).…”

Section: Discussionmentioning

confidence: 99%

Comparative efficaciesin vitroof antibacterial, fungicidal, antioxidant, and herbicidal activities of momilatones A and B

Fukuta¹,

Xuan²,

Deba³

et al. 2007

Journal of Plant Interactions

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Momilactones A (M A ) and B (M B ) are phytoalexins derived from rice plant (Oryza sativa) and were considered to be a part of the mechanism of rice self-defense system. The present study was to evaluate the comparative efficacies in vitro of antibacterial, fungicidal, antioxidant, and herbicidal activities of M A and M B . In general, M B shows higher antifungal, antibacterial, and herbicidal action than M A , although its antioxidant property was less than M A . In herbicidal trial, the IC 50 values of M B against germination, shoot and root elongation of barnyardgrass and monochoria were 40.9, 45.5, and 27.5, and 27.1, 17.3, and 0.9 mg, respectively. For M A , these values were 40.3, 35.6, and 55.1, and 43.9, 24.3, and 0.5 mg, respectively. For antifungal activity, momilactone B (IC 50 : 1.2, 123.9, and 53.4 mg) exerted significantly greater inhibition than M A (IC 50 : 78.1, 198.1, and 95.3 mg) against Botrytis cinerea, Fusarium solani, Colletrotrichum gloeosporioides, respectively, except for Fusarium oxysporum that both M A and M B showed no marked difference. In addition, M B exhibited significantly stronger antibacterial activity than M A against Pseudomonus ovalis, Bacillus cereus, and Bacillus pumilus, whereas the inhibitory activity of the two compounds was similar against Escherichia coli. Both M A and M B exerted rather weak antioxidant activity (EC 50 was 783.9 and 790.7 mg, respectively), of which M A showed a slightly stronger antioxidant activity than M B . This study is the first to examine antifungal, antibacterial, and antioxidant activities of two phytoalexins, as well as their comparative efficacies against growth of the noxious weeds barnyardgrass and monochoria.

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Section: Discussionmentioning

confidence: 99%

Comparative efficaciesin vitroof antibacterial, fungicidal, antioxidant, and herbicidal activities of momilatones A and B

Fukuta¹,

Xuan²,

Deba³

et al. 2007

Journal of Plant Interactions

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“…Therefore, natural products isolated from plants are an alternative to synthetic fungicides. Terpenoids, phenolic compounds, nitrogen-containing compounds, and aliphatic compounds isolated from plants have shown antifungal properties [3][4][5] . Grape pomaces are an important source of phenolic compounds 6 .…”

Section: Introductionmentioning

confidence: 99%

Improvement of the Antifungal Activity Against Botrytis Cinerea of Syringic Acid, a Phenolic Acid From Grape Pomace

Mendoza

Castro

Melo

et al. 2016

J. Chil. Chem. Soc.

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The aim of this study was to improve the antifungal activity against Botrytis cinerea of syringic acid by using the enzyme laccase to synthesize a heterodimeric compound by a coupling reaction with aniline. The synthesized heterodimer is a quinone-imine like compound (2,6-dimethoxy-4-(phenylimino)benzenone), which was characterized by using 1 H and 13 C NMR, IR, and mass spectrometry. The antifungal activity of the heterodimeric compound against B. cinerea was determined in vitro and showed a higher antifungal effect than the substrates (syringic acid and aniline), inhibiting the mycelial growth with an IC 50 value of 0.14mM and delayed 2 hours the conidial germination. Also, using the fluorochrome calcofluor white, cell wall damage was observed when B. cinerea was incubated with the compound. This is the first report on antifungal activity of this type of compound against B. cinerea.

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“…Nos últimos anos, a busca de compostos com atividades antifúngicas, antitumorais e antioxidantes tem sido intensifi cada por levar à identifi cação de novos fármacos que possam ser empregados no tratamento da AIDS e do câncer, e suas complicações (Grayer;Harborne, 1994;Gordon, 1996).…”

Section: Introductionunclassified

Biciclogermacreno, resveratrol e atividade antifúngica em extratos de folhas de Cissus verticillata (L.) Nicolson & Jarvis (Vitaceae)

Silva¹,

Oniki²,

Agripino³

et al. 2007

Rev. bras. farmacogn.

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RESUMO:Cissus verticillata L. (Vitaceae) tem sido empregada popularmente como antidiabética. Nessa espécie foi também detectada atividade fungitóxica. O objetivo do presente trabalho foi realizar a identifi cação dos compostos fungitóxicos em extratos de folhas. O extrato etanólico foi submetido a fracionamento com solventes de diferentes polaridades (hexano, clorofórmio, acetato de etila e butanol) e seu efeito antifúngico foi analisado frente a Cladosporium sphaerospermum. Os extratos em clorofórmio e acetato de etila mostraram atividade, e foram fracionados por cromatografi a em coluna e cromatografi a preparativa em placas de sílica, respectivamente. Três terpenóides foram isolados do extrato em clorofórmio; um deles foi identifi cado, por análise em CG-EM, como um sesquiterpeno, o biciclogermacreno. O composto ativo do extrato em acetato de etila foi identifi cado, por análises em CLAE, como o estilbeno resveratrol.Unitermos: Cissus verticillata, Vitaceae, atividade fungitóxica, sesquiterpeno, estilbeno.ABSTRACTS: "Bicyclogermacrene, resveratrol and fungitoxic activity on leaves extracts of Cissus verticillata L. Nicolson & Jarvis (Vitaceae)". Cissus verticillata L. (Vitaceae) is popularly employed as hypoglicemic and it shows fungitoxic activity. This work aims at identifi cation of fungitoxic compounds on extracts of leaves. The ethanol extract was partitioned using solvents of different polarities (hexane, chloroform, ethyl acetate and butanol) and its fungitoxic activity was analysed upon Cladosporium sphaerospermum. The chloroform and ethyl acetate extracts showed activity and they were fractionated by column chromatography and preparative TLC, respectively. Three terpenoids were isolated from the chloroform extract, one of them identifi ed by GLC-MS analysis as sesquiterpene bicyclogermacrene. The active compound of the ethyl acetate extract was identifi ed by HPLC analyses as stilbene resveratrol.

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A survey of antifungal compounds from higher plants, 1982–1993

Cited by 452 publications

References 161 publications

Comparative efficaciesin vitroof antibacterial, fungicidal, antioxidant, and herbicidal activities of momilatones A and B

Comparative efficaciesin vitroof antibacterial, fungicidal, antioxidant, and herbicidal activities of momilatones A and B

Improvement of the Antifungal Activity Against Botrytis Cinerea of Syringic Acid, a Phenolic Acid From Grape Pomace

Biciclogermacreno, resveratrol e atividade antifúngica em extratos de folhas de Cissus verticillata (L.) Nicolson & Jarvis (Vitaceae)

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