A Survey of Chinese Medicinal Herbal Treatment for Chemotherapy-Induced Oral Mucositis

Meyer-Hamme, Gesa; Beckmann, Kathrin; Radtke, J; Efferth, Thomas; Greten, Henry Johannes; Rostock, Matthias; Schröder, Sven

doi:10.1155/2013/284959

Cited by 42 publications

(28 citation statements)

References 75 publications

(94 reference statements)

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“…Under normal conditions, a large amount of bacteria presenting endotoxin reside in the intestine and are strictly confined by the barrier of the intestinal mucosa. But this barrier could be broken by doxorubicin, which is known to be capable of disrupting the epithelium to induce oral ulcers, intestinal inflammation, and hemorrhagic cystitis in cancer patients (13,14). If doxorubicin caused damage in the intestinal mucosa, endotoxin could enter the circulation and stimulate systemic inflammation.…”

Section: Introductionmentioning

confidence: 99%

Doxorubicin-Induced Systemic Inflammation Is Driven by Upregulation of Toll-Like Receptor TLR4 and Endotoxin Leakage

et al. 2016

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Doxorubicin is one of the most effective chemotherapeutic agents used for cancer treatment, but it causes systemic inflammation and serious multiorgan side effects in many patients. In this study, we report that upregulation of the proinflammatory Toll-like receptor TLR4 in macrophages by doxorubicin is an important step in generating its toxic side effects. In patient serum, doxorubicin treatment resulted in leakage of endotoxin and inflammatory cytokines into circulation. In mice, doxorubicin damaged the intestinal epithelium, which also resulted in leakage of endotoxin from the gut flora into circulation. Concurrently, doxorubicin increased TLR4 expression in macrophages both in vitro and in vivo, which further enhanced the sensitivity of these cells to endotoxin. Either depletion of gut microorganisms or blockage of TLR4 signaling effectively decreased doxorubicininduced toxicity. Taken together, our findings suggest that doxorubicin-triggered leakage of endotoxin into the circulation, in tandem with enhanced TLR4 signaling, is a candidate mechanism underlying doxorubicin-induced systemic inflammation. Our study provides new insights for devising relevant strategies to minimize the adverse effects of chemotherapeutic agents such as doxorubicin, which may extend its clinical uses to eradicate cancer cells. Cancer Res; 76(22); 6631-42. Ó2016 AACR.

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Section: Introductionmentioning

confidence: 99%

Doxorubicin-Induced Systemic Inflammation Is Driven by Upregulation of Toll-Like Receptor TLR4 and Endotoxin Leakage

et al. 2016

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“…However, studies have been conducted to evaluate the effects of other complementary attempts such as chamomile, black mulberry syrup, kefir, and Chinese herbs on chemotherapy-induced oral mucositis. 20,22,44,45 In these studies, the incidence of oral mucositis varied between 23.3% and 40%. Considering the results presented here, the incidence of oral mucositis was comparable to that of the previous reports.…”

Section: Discussionmentioning

confidence: 97%

“…14,21,22 These herbs have antiseptic, [23][24][25] anti-inflammatory, [23][24][25] antimicrobial, 23,24,26,27 antifungal, 23,27,28 and antiviral, 24,28 properties. In addition, these herbs are effective as a mouthwash or mouth rinse against stomatitis, 24,25 pharyngolaryngitis, and oral candidiasis.…”

Section: Introductionmentioning

confidence: 99%

Sage tea–thyme–peppermint hydrosol oral rinse reduces chemotherapy-induced oral mucositis: A randomized controlled pilot study

Yayla

İzgü

Özdemir

et al. 2016

Complementary Therapies in Medicine

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“…A critical understanding of the concept of the ecosystem both in a biological and in a cultural sense also implies ethical questions, if herbs might reveal side and toxicities on the one hand, but can be also used to alleviate the severe side effects of cytotoxic cancer chemotherapy on the other hand [55][56][57][58][59]. Such questions gain even more importance, if traditional medicine is the only available means for primary health care in rural areas of developing countries or if expensive medication for the treatment of infectious tropical diseases is not affordable for many poor people [60,61].…”

mentioning

confidence: 99%

Life Sciences—Life Writing: PTSD as a Transdisciplinary Entity between Biomedical Explanation and Lived Experience

Paul

Banerjee²,

Efferth

2015

Humanities

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Abstract:Since the second half of the 20th century, the life sciences have become one of the dominant explanatory models for almost every aspect of human life. Hand in hand with biomedical developments and technologies, the life sciences are constantly shaping and reshaping human lives and changing human biographies in manifold ways. The orientation towards life sciences and biomedicine from the very beginning to the end of human life is driven by the utopian notion that all forms of contingency could be technologically and medically controlled. This paper addresses the interrelatedness of life sciences and human biographies in a field where contingency and risk become essential and existential parts of lived experience: post-traumatic stress disorder (PTSD). On the one hand, this diagnostic entity is related to (neuro-)biological underpinnings of (a lack of) psychic resilience as well as to those of contemporary pharmacotherapy. On the other hand, PTSD is also understood as based on a traumatic life event, which can be accessed through and addressed by talk therapy, particularly narrative exposure therapy (NET). We argue that a novel focus on concepts of narrativity will generate pathways for an interdisciplinary understanding of PTSD by linking biological underpinnings from neurobiological findings, to brain metabolism and pharmacotherapy via the interface of psychotherapy and the specific role of narratives to the lived experience of patients and vice versa. The goal of our study is to demonstrate why therapies such as psychotherapy or pharmacotherapy are successful in controlling the disease burden of PTSD to some extent, but the restitutio ad integrum, the reestablishing of the bodily and psychic integrity remains out of reach for most PTSD patients. As a test case, we discuss the complementary methods of Traditional Chinese Medicine (TCM) and the established procedures of talk therapy (NET) to show how a methodological focus on narratives enhanced by notions of narrativity from the humanities grants access to therapeutically meaningful, enriched notions of PTSD. We focus on TCM because trauma therapy has long since become an intrinsic part of this complementary medical concept which are more widely accessible and accepted than other complementary medical practices, such as Ayurveda or homeopathy. Looking at the individual that suffers from a traumatic life event and also acknowledging the contemporary concepts of resilience, transdisciplinary concepts become particularly relevant for the medical treatment of and social reintegration of patients such as war veterans. We emphasize the necessity of a new dialogue between the life sciences and the humanities by introducing the concepts of corporeality, capability and temporality as boundary objects crucial for both the biomedical explanation, the narrative understanding and the lived experience of trauma.

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A Survey of Chinese Medicinal Herbal Treatment for Chemotherapy-Induced Oral Mucositis

Cited by 42 publications

References 75 publications

Doxorubicin-Induced Systemic Inflammation Is Driven by Upregulation of Toll-Like Receptor TLR4 and Endotoxin Leakage

Doxorubicin-Induced Systemic Inflammation Is Driven by Upregulation of Toll-Like Receptor TLR4 and Endotoxin Leakage

Sage tea–thyme–peppermint hydrosol oral rinse reduces chemotherapy-induced oral mucositis: A randomized controlled pilot study

Life Sciences—Life Writing: PTSD as a Transdisciplinary Entity between Biomedical Explanation and Lived Experience

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