A survey of Crimean-Congo haemorrhagic fever in livestock and ticks in Ardabil Province, Iran during 2004–2005

Telmadarraiy, Zakkyeh; Ghiasi, Seyed Mojtaba; Moradi, Maryam; Vatandoost, Hassan; Eshraghian, Mohammad Reza; Faghihi, Faezeh; Zarei, Zabiollah; Haeri, Azadeh; Chinikar, Sadegh

doi:10.3109/00365540903362501

Cited by 63 publications

(40 citation statements)

References 13 publications

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“…One possible reason for the lower prevalence of infection in cattle (13.0%) could be the low frequency of pasture usage of dairy cattle in the region; however, small ruminants are continuously in the pasture during the season. In accordance with our results, similar studies (7,12,14,15,18) confirmed that the CCHF antibody prevalence is generally higher in small ruminants than cattle. Although there are no similar data from Turkey to compare the results, very limited surveys were conducted in the endemic region.…”

Section: Discussionsupporting

confidence: 93%

“…Different serological results have been reported in livestock animals in various countries, i.e., 57.7% in Niger (11), 39.3% in Iran (15), and 3.13% in Egypt (12). The overall seroprevalence rate of 33.1%, which is comparable to some previous studies (18), indicates that CCHF virus infection is moderately distributed throughout the studied population.…”

Section: Discussionmentioning

confidence: 99%

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Crimean-Congo Hemorrhagic Fever infection in domestic animals in Marmara region, Western Turkey

Tuncer¹,

Yeşilbağ²,

Alpay³

et al. 2014

Ankara Üniversitesi Veteriner Fakültesi Dergisi

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Summary:Crimean-Congo hemorrhagic fever (CCHF) has been an important health issue in Turkey since the last decade.Although there is a well-described endemic area, the infection tends to disseminate into non-endemic areas. In the South Marmara region, a non-endemic area, serological and virological investigations were performed to evaluate the infection status in livestock animals. Among 508 blood samples collected from 5 different locations, 33.1% were positive for CCHF-neutralizing antibodies. The highest seroprevalence rate was detected in goats (66.0%), followed by sheep (31.8%) and cattle (13.0%) (p< 0.0001). There were extensive differences in seroprevalence rates in neighboring locations, i.e., 7.8% in Keles and 47.6% in the Orhaneli district of Bursa province. Using antigen-capture ELISA (Ag-ELISA) and real-time reverse transcription PCR (rt RT-PCR), 6.6% of the tested animals were found to be viremic at the time of sampling. Two samples that were negative by Ag-ELISA produced a positive signal in rt RT-PCR, indicating the higher sensitivity of the latter method for detecting viremic animals. The results of this study demonstrate the wide distribution of CCHF virus in some locations in a non-endemic area, which may lead to the generation of focal infectious areas.Key words: Cattle, Crimean-Congo hemorrhagic fever, ELISA, real-time RT-PCR, sheep, Turkey. Marmara bölgesindeki evcil hayvanlarda Kırım-Kongo Kanamalı Ateşi enfeksiyonuÖzet: Kırım-Kongo kanamalı ateşi (KKKA) son on yıllık süreç içerisinde Türkiye'de oldukça önemli bir sağlık problemi olarak gündemde yer almaktadır. Endemik bölge olarak tanımlanan alanlar dışında kalan non-endemik bölgelerde de enfeksiyonun yayılma eğiliminde olduğu görülmektedir. Bu çalışmada non-endemik bölge olarak tanımlanan Güney Marmara bölgesindeki çiftlik hayvanlarında enfeksiyon durumunu değerlendirebilmek amacıyla serolojik ve virolojik araştırmalar yapılmıştır. Bu amaçla 5 farklı noktadan 508 adet kan örneği toplanmıştır. Bu örneklerin %33,1'i KKKA-nötralizan antikorları yönünden pozitif çıkmıştır. En yüksek seroprevalans değeri keçilerde (%66,0) saptanırken, bu değeri sırasıyla koyunlar (%31,8) ve sığırlar (%13,0) izlemiştir (p<0,0001). Seroprevalans değerlerinde komşu bölgeler arasında büyük farklar olduğu görülmüştür. Örneğin; Keles'te %7,8 olan seroprevalans değeri Orhaneli'de %47,6 olarak tespit edilmiştir. Antijen ELISA (Ag-ELISA) ve real-time reverse transkriptaz PCR (rt RT-PCR) kullanılarak test edilen hayvanların %6,6'sının örnekleme sırasında viremi fazında olduğu tespit edilmiştir. Ag-ELISA ile negatif, rt RT-PCR ile pozitif sonuç veren iki örnek, ikinci metodun viremi fazındaki hayvanları saptamada daha duyarlı olduğunu göstermiştir. Bu çalışmanın sonucu KKKA virusunun non-endemik bölgenin bazı noktalarında oldukça yaygın olduğunu ve bu noktaların enfeksiyon odağı olabileceğini göstermiştir.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Crimean-Congo Hemorrhagic Fever infection in domestic animals in Marmara region, Western Turkey

Tuncer¹,

Yeşilbağ²,

Alpay³

et al. 2014

Ankara Üniversitesi Veteriner Fakültesi Dergisi

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“…CCHF antibodies were detected in 5.9% of sampled cattle in Iran (Lotfollahzadeh et al, 2011). Differences were observed for the sero-prevalence in various livestock species in many studies (Mariner et al, 1995;Hassanein et al, 1997;Mohamed et al, 2008;Telmadarraiy et al, 2010;Albayrak et al, 2012;Adam et al, 2013).…”

Section: Discussionmentioning

confidence: 97%

“…Many authors have documented the antigen detection in ticks collected in various regions of the world through similar methods (Telmadarraiy et al, 2010;Albayrak et al, 2012;Estradapena et al, 2012). …”

Section: Discussionmentioning

confidence: 99%

Cross-sectional survey of Crimean-Congo hemorrhagic fever virus in the sultanate of Oman

Body¹,

Abdulmajeed²,

Hammad³

et al. 2016

J. Vet. Med. Anim. Health

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Crimean-Congo hemorrhagic fever (CCHF) is a tick-borne hemorrhagic disease caused primarily by a zoonotic virus. The disease may cause a fatal hemorrhagic illness in human; however, CCHF is asymptomatic in infected animals. After the recent reports of CCHF in Oman, a cross-sectional survey was conducted during 2013 to 2014 to study the prevalence in livestock and ticks in order to assess the potential risk of emergence. 1289 serum samples were collected from different domestic animals, and tested by two types of modified ELISA (Indirect and competitive ELISA) for detection of CCHF specific immunoglobulin G (IgG). A prevalence of 7.1% positive serum samples was recorded. Highest individual prevalence was recorded in cattle (17.5%) followed by camels (15.7 %), goat (4.8%) and sheep (4.3%). Moreover, 174 ticks were also collected from 179 location. In total, 9 tick samples were found positive for CCHF virus by Antigen-capture ELISA test and RT-PCR which represents 5.1%. Moreover, the concomitant findings of positive sera for animals and detection of CCHF virus was reverse transcription polymerase chain reaction (RT-PCR). This study aims to estimate the disease distribution in livestock in Oman, identify areas under high risk, and contemplate a comprehensive control strategy.

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“…Sporadic outbreaks of CCHF have been reported from Kosovo, Senegal, Turkey, Bulgaria, Iran, Pakistan, and Mauritania (2,(7)(8)(9). The predominant hosts of CCHFV include wild and domestic mammals and birds.…”

Section: Introductionmentioning

confidence: 99%

Spatial and Phylodynamic Survey on Crimean-Congo Hemorrhagic Fever Virus Strains in Northeast of Iran

Faghihi

Telmadarraiy

Chinikar

et al. 2018

Jundishapur J Microbiol

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Background: Crimean-Congo hemorrhagic fever (CCHF) is asymptomatic in infected animals, yet the virus poses a serious threat to humans causing a symptomatic, hemorrhagic disease with a high case-fatality rate. Numerous genera of ticks serve as both vectors and reservoirs of the Crimean-Congo hemorrhagic fever virus (CCHFV). Objectives:The aim of the present study is to determine the CCHFV prevalence in ticks from northeast Iran to establish a phylogenetic relationship of the tick-derived CCHFV strains circulating in Iran.Methods: During April to June 2013, a total of 93 hard ticks were collected from different animals in the Damghan district. The Ssegment of positive samples was fully sequenced using the Sanger technique. A total of 142 CCHFV sequences comprised full-length of CCHFV sequences obtained in this study were aligned using the MAFFT algorithm, then phylogenetic tree was constructed using Geneious v 7.1.8. Results:The identified tick species included Hyalomma marginatum (6.5%), Hy. dromedarii (21.5%), Hy. anatolicum (15.1%), Hy. asiaticum (3.2%) and Hy. schulzei (2.2%), as well as Rhipicephalus sanguineus (47.3%). The CCHFV RNA was detected in 4 samples of 93 tick samples (4.3%) by RT-PCR. A total of 4 CCHFV sequences were obtained in this study clustered within clade IV (Asia-1 and Asia-2). Conclusions:We demonstrated that 4 species of hard ticks could be a vector for CCHFV in Iran. In addition, our findings indicate the circulation of CCHFV clade IV strain in the northeast of Iran and provide a solid base for more targeted surveillance and prevention programs in Iran.

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A survey of Crimean-Congo haemorrhagic fever in livestock and ticks in Ardabil Province, Iran during 2004–2005

Cited by 63 publications

References 13 publications

Crimean-Congo Hemorrhagic Fever infection in domestic animals in Marmara region, Western Turkey

Crimean-Congo Hemorrhagic Fever infection in domestic animals in Marmara region, Western Turkey

Cross-sectional survey of Crimean-Congo hemorrhagic fever virus in the sultanate of Oman

Spatial and Phylodynamic Survey on Crimean-Congo Hemorrhagic Fever Virus Strains in Northeast of Iran

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