A survey of delayed response performance by normal and brain-damaged monkeys.

Meyer, Donald R.; Harlow, Harry F.; Settlage, Paul H.

doi:10.1037/h0053542

Cited by 56 publications

(41 citation statements)

References 8 publications

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“…Contrary to early reports Jacobsen, 1936;Finan, 1939;Meyer et al, 1951), unilateral ablation of the prefrontal cortex has been shown to be sufficient to produce a delayed-response deficit, although of less magnitude than that produced by bilateral ablation (Warren et al, 1969a;Warren and Nonneman, 1976). No relationship has been found between hemispheric dominance and the magnitude of the deficit (Warren and Nonneman, 1976).…”

Section: Anatomical Factorsmentioning

confidence: 58%

“…The presence and length of that delay predict whether or not the workingmemory deficit will be observable after frontal ablation (Meyer et al, 1951;Meyer and Harlow, 1952;Gross, 1963b;Treichler et al, 1971;Miller and Orbach, 1972). The presence and length of that delay predict whether or not the workingmemory deficit will be observable after frontal ablation (Meyer et al, 1951;Meyer and Harlow, 1952;Gross, 1963b;Treichler et al, 1971;Miller and Orbach, 1972).…”

Section: Temporal Factorsmentioning

confidence: 99%

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Animal Neuropsychology

Fuster

2015

The Prefrontal Cortex

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Section: Anatomical Factorsmentioning

confidence: 58%

Section: Temporal Factorsmentioning

confidence: 99%

Animal Neuropsychology

Fuster

2015

The Prefrontal Cortex

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“…In addition, while the performance rate of normal monkeys was not altered, all lesion monkeys (W-33, W-36, W-37, W-38, W-40) developed slight but definite deterioration of acquired correct performance rate when the delay was increased from 10 to 20 sec in the delayed alternation test. The latter finding appears to be in direct contrast to the negative report of unilateral lesion monkeys in delayed response test with increased delay of up to 40 sec (11).…”

Section: Impaired Learning and Unilateral Lesionmentioning

confidence: 62%

Chronic Focal Cortical Epileptogenic Lesion and Behavior Comparison of Behavioral Performance in Monkeys with either Epileptogenic or Ablative Unilateral Lesion

Seino¹,

Wada²

1964

Epilepsia

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SUMMARY Three groups of monkeys: (i) those with no lesion; (ii) those with chronic unilateral frontal destructive lesion; and (iii) those with chronic unilateral epileptogenic lesion, were subjected to the spatial delayed response and delayed alternation tests. The following results were obtained. Monkeys with lesions, either destructive or epileptogenic, were inferior to normal monkeys in learning the spatial delayed response as well as delayed alternation problem. A lower rate of correct performance was associated with a persistent position habit in the delayed response test, but the side of the position habit was neither related to the side of the preferential hand used nor to the side on which the lesions were made. Improvement in the delayed alternation test was paralleled by development of an alternate use of both hands. Monkeys with a destructive lesion: (a) exhibited a strong tendency to hyperactivity and of instantaneous response in the testing situations; and (b) persistently failed to extinguish the approach response pattern even after an extensive extinction trial. Such tendencies were not present in monkeys with an epileptogenic lesion. Monkeys with an epileptogenic lesion showed a persistent tendency of recurrent non‐response or slow‐response and their performance was poorest among the three groups. This impaired performance was not associated with hyperactivity or behavioral seizure phenomena. Although the presence of marked intergroup behavioral difference between monkeys with epileptogenic and destructive lesions suggests the neural basis for an impaired acquisition in these two groups could not be identical, it is suggested that functional alterations of the contralateral homologous frontal cortical area and/or of the ipsilateral deep structures has to be taken into consideration to account for such impairment in the monkeys with unilateral frontal lesion. RÉSUMÉ Trois groupes de singes, (i) sans lésion, (ii) avec lésion chronique destructive unilatéral frontale, et (iii) avec lésion chronique épileptogene frontale unilatérale, ont été soumis au test de réponse spatiale différée et au test d'alternance différée. Les résultats suivants ont été obtenus: Les singes avec une lésion frontale, qu'elle soit destructive ou épileptogène, se sont montrés inférieurs aux singes normaux dans l'apprentissage des deux tests. Au test de réponse différée, un taux inférieur de performances correctes s'est trouvé associéà une habitude de position, mais le côté de cette position habituelle ne s'est pas montré lié au côte de la main préférée ni au côté des lésions. Avec le test d'alternance différée, 1'amélioration s'est faite parallèlement à l'utilisation alternée des deux mains. Les singes avec une lésion destructive ont montré: a) une forte tendance à l'hyperactivité et aux réponses instantanées dans la situation expérimentale; b) une incapacité persistante à inhiber la réponse d'approche, même après une importante épreuve d'extinction. De telles tendances n'ont pas été observées chez les singes avec une lé...

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“…The outstanding symptoms of frontal lobe lesion, in lower forms, are hypermotility, defective performance on delayed-response and delayed-alternation tasks, and a diminished capacity for overcoming spontaneous or acquired response preferences (Bianchi 1895;Blum 1952;Jacobsen 1935;Lawicka and Konorski 1959;Mishkin et al 1962;Meyer et al 1951). During the last three days two things have become abundantly clear: First, despite their family resemblance, these assorted aspects of frontal lobe dysfunction, in infrahuman species, are dissociable, since any one of these symptoms can be shown to occur without the others.…”

Section: Comparison With Infrahuman Formsmentioning

confidence: 99%

The Riddle of Frontal Lobe Function in Man

Teuber¹

2009

Neuropsychol Rev

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A survey of delayed response performance by normal and brain-damaged monkeys.

Cited by 56 publications

References 8 publications

Animal Neuropsychology

Animal Neuropsychology

Chronic Focal Cortical Epileptogenic Lesion and Behavior Comparison of Behavioral Performance in Monkeys with either Epileptogenic or Ablative Unilateral Lesion

The Riddle of Frontal Lobe Function in Man

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