Although animal-assisted interventions (AAIs) share specific characteristics, their differences can be quite significant (Lajoie, 2003). Most research on AAIs focuses on the human side (Muñoz Lasa et al., 2011). The autonomy and well-being of the animals involved are seldom studied, as well as the possible values of conflict between humans and animals (Glenk, 2017). The COVID-19 pandemic that gripped the world starting in 2019–2020, greatly affected human-animal interaction projects, such as animal-assisted interventions (Kumar et al., 2020). To control the spread of the SARS-CoV-2 virus, several (inter)national organisations, came up with new safety protocols. We focus on scientific insights and anecdotal observations, as well as the ethical implications of the COVID-19 safety protocols on AAIs in Belgium and Italy. The paper aims to give the reader an insight into the complexity of AAIs and its future relevance for developing protocols to handle the current and maybe future pandemics.