A Survey of Genetic Resistance to Leukosis-Sarcoma Viruses in Commercial Stocks of Chickens

Crittenden, L. B.; Motta, J.

doi:10.3382/ps.0481751

Cited by 41 publications

(22 citation statements)

References 12 publications

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“…In chickens, one pair of autosomal alíeles, a s and a', of the tumour virus a (tva) locus, with dominance of the former susceptibility alíele over the latter, controls infection of the chorioallantoic membrane (CAM), and of chick embryo fibroblasts (CEF) by leukosis/sarcoma viruses of subgroup A (Crittendenei ai, 1967;Crittenden and Motta, 1969;Pañi, 1974). The CAM-assay is recognised as an efficient and reliable method for screening chicken flocks for susceptibility to Rous sarcoma virus (RSV) of subgroup A (Prince, 1958a,b;Crittenden and Motta, 1969;Pani and Biggs, 1973).…”

Section: Introductionmentioning

confidence: 99%

Inheritance of fibrosarcomatous liver tumours in White Leghorn chicks inoculated vu the chorioallantoic membrane with subgroup A Rous sarcoma virus: A four‐allele genetic model

Pani

Naithani

1990

Avian Pathology

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SUMMARYAn investigation was made using White Leghorn fowl to study the genetic control of subgroup A Rous sarcoma virus-induced fibrosarcomatous liver tumours (LT) in chicks inoculated via the chorioallantoic membrane (CAM). A total of 723 CAM-inoculated embryos were hatched in three experiments. In Expt 1, CAM-susceptibility and LT-mortality were examined on a within sire family basis to ascertain the inter-relationship between the two paramaters. In Expt 2, sires that had records of high or low LT(+) deaths in the families were selected to produce progeny within high and low incidence lines in the next generation to ascertain the amenability of the trait (LT death) to selection pressure. Survivors of LT-assay (Expt 1) were mated inter se in Expt 3 to study the inheritance of the two traits according to known or proposed genetic models. It was shown that LT mortality is a genetic trait because of its amenability to selection, with a high realised heritability (h 2 R = 1.16). In the three experiments, most CAM-susceptibles (S) died of LT(+), and most CAM-resistants(R) survived, but there were some conversely associated phenotypes i.e. S(LT-) and R(LT+). The conventional 2-allele model of the tva (tumour virus a) locus with pleiotropic effect, or a 2-locus model with linkage, were considered inadequate to explain the occurrence of conversely associated phenotypes on a within family basis. However, a 4-allele model of the tva locus showed a good fit to the results of this study.

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Section: Introductionmentioning

confidence: 99%

Inheritance of fibrosarcomatous liver tumours in White Leghorn chicks inoculated vu the chorioallantoic membrane with subgroup A Rous sarcoma virus: A four‐allele genetic model

Pani

Naithani

1990

Avian Pathology

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“…The frequency of LLV shedders among the primary breeding stock hens was lower than that detected among Leghorns (Spencer etal, 1979;Gavora et at, 1980). This might be explained by a higher incidence of genetic resistance to infection with the prevailing LL viruses of subgroups A and B, since Crittenden and Motta (1969) showed that frequency of genetic resistance to infection, particularly with sub group B virus, tended to be higher in heavy-breed and brown-egg stocks than in white-egg stocks (Leghorns). The large difference between the frequency of LLV positive birds in males and females in 1979 is unexplained.…”

Section: Causes Of Mortalitymentioning

confidence: 70%

Performance of meat‐type chickens test‐positive and ‐negative for lymphoid Leukosis virus infection¹

1982

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SUMMARYFour "sire-line" and seven "dam-line" breeding stocks of meat-type chickens were purchased as 1-day-old chicks from commercial breeders. One egg from each of 61 to 81 hens per stock was tested at 245-280 days of age for presence of group specific antigen of the lymphoid leukosis virus (LLV). Subsequently, cloacal swabs collected at 42 days of age from 93 male and 188 female progeny of particular "dam-line" stocks were tested for LLV. The percentage of LLV shedders in the individual stocks varied from 0 to 15%. Egg production to 385 days was lower in shedders than in nonshedders by 10 eggs per hen housed and by eight eggs per surviving hen. In the crossbred progeny of the "dam-line" stocks tested for LLV at broiler age, males had a significantly lower percentage of positives (2%) than females (11%). The broiler-age body weight of the test-positive females was 5% lower and, to 315 days of age, their mortality was 29% higher and egg production per hen housed 28 eggs lower than in the negative birds.

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“…White Leghorn (WL), was upheld by us (Pani and Biggs, 1973) and by others (Crittenden and Motta, 1969). Due to lack of bimodality of pock counts in heavy breeds, in contrast to WL, single gene control was neither supported nor rejected by the latter workers, the excess low pock count CAMs perhaps having arisen due to interference, as discussed above.…”

Section: Discussionmentioning

confidence: 99%

“…The CAM-test (Prince, 1958;Dougherty et al, 1960) has usually been used for screening commercial chicken flocks in order to determine the distribution of the recessive resistance a r gene (Crittenden and Motta, 1969;Pani and Biggs, 1973). However, the process of developing genetically resistant stock by selecting resistant families based on the progeny test is slower than mass/individual selection, which is obviously not possible with the CAM-test.…”

Section: Pjcpaniefc/mentioning

confidence: 99%

Hatchability and mortality following infection of chick embryos with subgroup a rous sarcoma virus

1988

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SUMMARYAn investigation, using Rhode Island Red, New Hampshire, Columbian and Australorp, was conducted to study the correlation between chorioallantoic membrane (CAM)-infection phenotype to challenge with Bryan strain of Rous sarcoma virus (BS-RSV) of subgroup A and subsequent mortality, following hatching. A total of 806 CAMs and 438 chicks over nine hatch-replicates in three experiments provided evidence that infection via an inoculation of the CAM induced rapid and high mortality, about 72%, averaged over the four breeds, from a fibrosarcomatous liver tumour (LT) in CAM-susceptible chicks. In contrast, only 14% of chicks inoculated via the yolk sac died from liver tumours.

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A Survey of Genetic Resistance to Leukosis-Sarcoma Viruses in Commercial Stocks of Chickens

Cited by 41 publications

References 12 publications

Inheritance of fibrosarcomatous liver tumours in White Leghorn chicks inoculated vu the chorioallantoic membrane with subgroup A Rous sarcoma virus: A four‐allele genetic model

Inheritance of fibrosarcomatous liver tumours in White Leghorn chicks inoculated vu the chorioallantoic membrane with subgroup A Rous sarcoma virus: A four‐allele genetic model

Performance of meat‐type chickens test‐positive and ‐negative for lymphoid Leukosis virus infection¹

Hatchability and mortality following infection of chick embryos with subgroup a rous sarcoma virus

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A Survey of Genetic Resistance to Leukosis-Sarcoma Viruses in Commercial Stocks of Chickens

Cited by 41 publications

References 12 publications

Inheritance of fibrosarcomatous liver tumours in White Leghorn chicks inoculated vu the chorioallantoic membrane with subgroup A Rous sarcoma virus: A four‐allele genetic model

Inheritance of fibrosarcomatous liver tumours in White Leghorn chicks inoculated vu the chorioallantoic membrane with subgroup A Rous sarcoma virus: A four‐allele genetic model

Performance of meat‐type chickens test‐positive and ‐negative for lymphoid Leukosis virus infection1

Hatchability and mortality following infection of chick embryos with subgroup a rous sarcoma virus

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Performance of meat‐type chickens test‐positive and ‐negative for lymphoid Leukosis virus infection¹