A survey of in vivo growth characteristics and spontaneous metastasizing potentials of C3H mouse mammary tumors

Abstract

This investigation examined the relationship between spontaneous metastasizing potential, immunogenicity and growth rate in 34 C3H/He mammary carcinomas. The main purpose of our studies was to examine the hypothesis that a tumor's metastasizing potential is affected by its immunogenicity. The tumors were studied during serial intra-mammary transplantations, starting with tissue from autochthonous, spontaneous pulmonary metastases. The results show that there was no correlation between metastasizing potential and tumor immunogenicity, and no correlation between metastasizing potential and tumor growth rate. Moreover, metastasizing potential was not related to invasive behavior, because histological examination showed that all of the metastases grew extensively within pulmonary vessels and displayed no tendency to active extravasation.

Validity of mouse mammary tumour models for human breast cancer: Comparative pathology

“…Many of the mammary tumors that the veterinary pathologists know by clinical experience will metastasize have the histological features the human surgical pathologist would regard as histologically "benign." For example, most samples of the MMTVinduced microacinar carcinoma are judged by human criteria as "adenomas" but 60 to 80% result in metastases (Vaage, 1989). On the other hand, the mouse mammary gland generally responds to injury with metaplasia or atypia that is regarded by the veterinary pathologist as dysplasia of repair.…”

Isolation and characterization of a low metastatic variant from EL-4 mouse T-lymphoma

“…However, the less metastatic variant EL-4ad exhibited more marked invasiveness than parental EL-4 in the in vitro invasion assay using Matrigel ( Figure 5). In the mouse, the lack of any correlation between the invasive activity and metastatic ability of malignant cells was also reported [41,42]. In was reported that the high-metastatic murine T-lymphoma variant (ESb) attached to liver cells whereas the low metastatic parent (Eb) did not [28].…”