A survey of mangiferin and hydroxycinnamic acid ester accumulation in coffee (Coffea) leaves: biological implications and uses

Campa, Claudine; Mondolot, Laurence; Rakotondravao, Arsene; Bidel, Luc; Gargadennec, Annick; Couturon, Emmanuel; Fisca, Philippe La; Rakotomalala, Jean-Jacques; Jay‐Allemand, Christian; Davis, Aaron P.

doi:10.1093/aob/mcs119

Cited by 104 publications

(131 citation statements)

References 77 publications

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“…To date, phenol histolocalization is generally done using Neu's reagent, which binds with phenolics, emitting a specific greenish-white epifluorescence under UV light (Neu, 1956). As expected, the most intense greenish-white fluorescence is observed in juvenile coffee leaf blades (Mondolot et al, 2006; Campa et al, 2012), but its specificity toward HQA is low. By contrast, mangiferin histolocalization by epifluorescence does not require any reagents and has been directly observed through its autofluorescence (Talamond et al, 2011; Campa et al, 2012).…”

Section: Introductionsupporting

confidence: 67%

“…CQA and diCQA are indeed the most abundant soluble hydroxycinnamic acids (HQA) present in leaves and seeds (Clifford, 1985; Ky et al, 2001; Campa et al, 2012). Three isomers occur in each class according to the acylating residue positions, but the most important in terms of content is 5- O -caffeoylquinic acid, more commonly known as chlorogenic acid (Clifford, 1985) (see Figure A in supplementary material).…”

Section: Introductionmentioning

confidence: 99%

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Spectral analysis combined with advanced linear unmixing allows for histolocalization of phenolics in leaves of coffee trees

et al. 2014

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An imaging method using spectral analysis combined with advanced linear unmixing was used to allow histolocalization of natural autofluorescent compounds such as hydroxycinnamic acid (chlorogenic acid) and xanthone (mangiferin) in living cells and tissues (mature coffee leaves). The tested method included three complementary steps: 1/ visualization of natural autofluorescence and spectrum acquisition with a multiphoton microscope; 2/ identification of some compounds using previous information on the chemical composition of the tissue, obtained from litterature; and 3/ localization of candidate compounds by spectral imaging. The second part of the study consisted of describing the histochemical structure of leaves during their development. This revealed very fast histochemical differentiation of leaves during the first week after their emergence. Lastly, young leaves of Coffea pseudozanguebariae (PSE), C. eugenioides (EUG), C. arabica (ARA) and C. canephora (CAN) were compared. This confirmed the presence of xanthone in PSE and EUG, but especially its precise tissue localization. This also highlighted the paternal CAN origin of the leaf structure in the allotetraploid species ARA. The limits and advantages of the method without staining are discussed relative to classical epifluorescence microscopy under UV light. This non-invasive optical technique does not require pretreatment and is an effective experimental tool to differentiate multiple naturally-occuring fluorochores in living tissues.

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Section: Introductionsupporting

confidence: 67%

Section: Introductionmentioning

confidence: 99%

Spectral analysis combined with advanced linear unmixing allows for histolocalization of phenolics in leaves of coffee trees

et al. 2014

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“…Generally, many research papers presented that the phenolic compounds were the good free radical scavenger. In addition, previous studies showed that coffee bean contained many polyphenolic compounds such as chlorogenic acid, mangiferin and hydroxycinnamic acid esters (Vignoli et al, 2011;Campa et al, 2012;Moreira et al, 2013). The major phenolic acid in all coffee samples was chlorogenic acid (Cheong et al, 2013).…”

Section: Determination Of Total Phenolic Contentmentioning

confidence: 84%

Evaluation of antioxidant and anti-tyrosinase activities as well as stability of green and roasted coffee bean extracts from Coffea arabica and Coffea canephora grown in Thailand

Kiattisin¹,

Nantarat²,

Leelapornpisid³

2016

J. Pharmacognosy Phytother.

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Coffea arabica (Arabica) and Coffea canephora (Robusta) are the economic plants in Thailand that are widely cultivated in Northern and Southern Thailand. This study aims to evaluate the antioxidant, antityrosinase activities, toxicity, stability and identify chemical components of the coffee bean extracts. The best extract that showed good biological activities will be further used to develop cosmeceutical products. Green and roasted coffee beans from two species were extracted with hexane following ethanol by maceration. Their antioxidant activities were detected by 2,2-diphenyl-1-picryl hydrazyl (DPPH), 2,2'-Azino-bis(3-ethylbenzthiazoline-6-sulphonic acid) (ABTS) and lipid peroxidation inhibition assays. In addition, anti-tyrosinase activity was also evaluated. The results revealed that the ethanolic coffee bean extracts showed a higher level of antioxidant activity than in the hexane extracts. All extracts also possessed a considerable anti-tyrosinase activity, but less potent than kojic acid and arbutin. Chemical compounds of these extracts were determined using caffeine and chlorogenic acid as standards of reference by the thin layer chromatography and the high performance liquid chromatography. The green coffee bean extracts consisted of caffeine and chlorogenic acid while the roasted coffee bean extracts presented only caffeine due to a few chlorogenic acid content after the roasting process. The ethanolic coffee bean extracts that showed good activities were selected to be evaluated on toxicity and stability. The selected extracts were kept at various storage conditions to evaluate their stability using DPPH assay and anti-tyrosinase activity assay. The result showed that the extracts were not toxic to cells. Therefore, the extracts were safe to be components in skin care products. After the stability test, the extracts indicated a good stability and activities. These results led to the conclusions that the coffee bean extracts possess a good biological activities and are assumed to be promising natural active ingredients with a good stability profile for further development of cosmeceutical or anti-aging products.

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“…62 Under irrigation or not, extracts from coffee leaves presented a band around 1665 cm -1 as important variable. This band is characteristic of the presence of the carbonyl group, for which this region may indicate the presence of several compounds such as proteins, 55 caffeine, 6,30 ketone between two aromatic rings 62 as in xanthone structures found in the form of mangiferin detected in coffee leaves, 7 among others. Bands indicated by loadings between 1100 and 1000 cm -1 are possibly C-O stretches of carbohydrates.…”

Section: Resultsmentioning

confidence: 98%

“…However, there is relatively little research carried out on metabolites in other coffee plant parts, including the leaves. [7][8][9][10][11] Phenolic compounds found in the coffee leaves 7 have been shown to be potentially beneficial for health, although the influence of consumption of these compounds on the human body requires further research. Other metabolite groups are found in coffee leaves, such as alkaloids, 12 several carbohydrates 13,14 and lipids 9 among others.…”

Section: Introductionmentioning

confidence: 99%

Irrigation and Light Access Effects on Coffea arabica L. Leaves by FTIR‑Chemometric Analysis

Sanchez¹,

Pauli²,

Scheel³

et al. 2017

J. Braz. Chem. Soc.

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Coffee bean chemical compositions has been extensively studied. However, there is a small amount of research on other parts of the coffee plant, including leaves. Fourier transform infrared (FTIR) spectral profiles of Coffea arabica L. cv. IAPAR 59 leaf extracts from a simplex-centroid design were studied by principal component analysis (PCA) to evaluate the effect of solvent extractor on its metabolites. PCA indicated that the extractor solvents containing ethanol were the most suitable for this study. FTIR spectra in conjunction with orthogonal signal correction and partial least squares-discrimination analysis (OSC-PLS-DA) were used to classify and discriminate the leaves of irrigated and non-irrigated plants by bands related to carbohydrates, amino acids and lipids. Leaves receiving different intensities of solar radiation were also discriminated by bands corresponding to caffeine, carbohydrates and lipids. FTIR spectral profile analyzed with chemometric tools showed to be a useful, powerful and simple procedure to discriminate coffee leaves collected from different microclimate conditions. Keywords:Coffea arabica leaves, simplex-centroid design, FTIR spectroscopy, chemometric analysis, environmental conditions IntroductionThe coffee plant is a woody, perennial, evergreen and dicotyledon species that belongs to the Rubiaceae family. 1,2 Among several species of the genus Coffea, two are considered economically important, i.e. Coffea canephora Pierre (Robusta coffee) and Coffea arabica L. (Arabica coffee). 3 The latter species represents 70% of world coffee production 2 due to finer flavor and aroma, and therefore is more consumed than Robusta. 4 Coffee is one of the most consumed beverages in the world 5,6 and an important raw material of the international trade. 4 Thus, due to its importance, the chemical composition of coffee beans has been extensively studied. However, there is relatively little research carried out on metabolites in other coffee plant parts, including the leaves.7-11 Phenolic compounds found in the coffee leaves 7 have been shown to be potentially beneficial for health, although the influence of consumption of these compounds on the human body requires further research. Other metabolite groups are found in coffee leaves, such as alkaloids, 12 several carbohydrates 13,14 and lipids 9 among others.Plant metabolites are susceptible to environmental changes and their responses can be evaluated by metabolomics analysis. 15 In periods of drought or excessive sun exposure, environmental stress can affect physiological processes in plants owing to their necessity to adapt to the new situation. In excess, these conditions can affect metabolic activities such as photosynthesis and growth rate modifying carbohydrate levels and protein synthesis. [16][17][18][19][20] In coffee plants, these changes may influence the metabolic quantities and consequently, the coffee bean quality. 9,21 Information about chemical modifications in coffee Sanchez et al. 169 Vol. 29, No. 1, 2018 leaves subjecte...

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A survey of mangiferin and hydroxycinnamic acid ester accumulation in coffee (Coffea) leaves: biological implications and uses

Cited by 104 publications

References 77 publications

Spectral analysis combined with advanced linear unmixing allows for histolocalization of phenolics in leaves of coffee trees

Spectral analysis combined with advanced linear unmixing allows for histolocalization of phenolics in leaves of coffee trees

Evaluation of antioxidant and anti-tyrosinase activities as well as stability of green and roasted coffee bean extracts from Coffea arabica and Coffea canephora grown in Thailand

Irrigation and Light Access Effects on Coffea arabica L. Leaves by FTIR‑Chemometric Analysis

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