A survey of psoriasis patients in Japan from 1982 to 2001

Kawada, Akira; Tezuka, Tadashi; Nakamizo, Yoshio; Kimura, Hideto; Nakagawa, Hidemi; Ohkido, Muneo; Ozawa, A.; Ohkawara, Akira; Kobayashi, Hitoshi; Harada, Shinji; Igarashi, Atsuyuki

doi:10.1016/s0923-1811(02)00142-1

Cited by 106 publications

(207 citation statements)

References 11 publications

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“…In contrast, a recent survey of psoriasis in 694 patients from Norway did not show any significant sex difference for both sexes (49). Also, in a survey of psoriasis patients in Japan, evidence points to a paternal overtransmission of psoriasis to males being more frequently affected (65.8%) compared with females (34.2%) (50). Thus, ethnic factors also appear to influence the sex prevalence of psoriasis.…”

Section: Cd18mentioning

confidence: 99%

Identification of Susceptibility Loci for Skin Disease in a Murine Psoriasis Model

Keß

Lindqvist

Peters

et al. 2006

The Journal of Immunology

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Psoriasis is a frequently occurring inflammatory skin disease characterized by thickened erythematous skin that is covered with silvery scales. It is a complex genetic disease with both heritable and environmental factors contributing to onset and severity. The CD18 hypomorphic PL/J mouse reveals reduced expression of the common chain of β2 integrins (CD11/CD18) and spontaneously develops a skin disease that closely resembles human psoriasis. In contrast, CD18 hypomorphic C57BL/6J mice do not demonstrate this phenotype. In this study, we have performed a genome-wide scan to identify loci involved in psoriasiform dermatitis under the condition of low CD18 expression. Backcross analysis of a segregating cross between susceptible CD18 hypomorphic PL/J mice and the resistant CD18 hypomorphic C57BL/6J strain was performed. A genome-wide linkage analysis of 94 phenotypically extreme mice of the backcross was undertaken. Thereafter, a complementary analysis of the regions of interest from the genome-wide screen was done using higher marker density and further mice. We found two loci on chromosome 10 that were significantly linked to the disease and interacted in an additive fashion in its development. In addition, a locus on chromosome 6 that promoted earlier onset of the disease was identified in the most severely affected mice. For the first time, we have identified genetic regions associated with psoriasis in a mouse model resembling human psoriasis. The identification of gene regions associated with psoriasis in this mouse model might contribute to the understanding of genetic causes of psoriasis in patients and pathological mechanisms involved in development of disease.

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Section: Cd18mentioning

confidence: 99%

Identification of Susceptibility Loci for Skin Disease in a Murine Psoriasis Model

Keß

Lindqvist

Peters

et al. 2006

The Journal of Immunology

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“…The authors attributed this finding either to an attenuating clinical burden of the disease with age leading to diagnostic gaps or to excess cumulative mortality of psoriatics. However, the recently reported constellation of decreasing discharge rates for psoriasis patients despite increasing admission numbers of patients with psoriasis history as a function of age, 29 in connection to the fact that no more than 5% of all psoriasis patients will present with disease-onset after the age of 70, 30 favors the former of the aforementioned explanations. A third explanation for a decreasing prevalence of psoriasis in cross-sectional studies as a function of age is that of increasing incidence of the disease as a function of calendar years.…”

Section: Discussionmentioning

confidence: 99%

The prevalence of psoriasis among elderly individuals: more questions than answers

et al. 2011

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Knowledge of epidemiological data of psoriasis among elderly people is limited. Herein the prevalence of psoriasis among non-permanently hospitalized, elderly (70-89 year old) individuals was assessed by a face-to-face interview using a structured questionnaire adapted from an earlier telephone survey elsewhere. 450 individuals 70-89 years old consented to contribute. Psoriasis was found in 15/450 individuals [life-long prevalence: 3.33%; (95% confidence intervals: 1.99-5.47%)]; 1/450 individuals have ever required systemic treatment (0.2% [0.01-1.4%]). This prevalence is about ten times higher than corresponding results of the aforementioned telephone survey with the same questionnaire. In conclusion this study: i) Provides the first estimation of psoriasis prevalence in Greece, albeit focused in a particular age group and demonstrates a relatively high life-long prevalence, however with minimal morbidity among older people; ii) Underscores the need for studies to evaluate the impact of proxy effects (e.g. telephone information) in assessing skin morbidity of older probands.

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“…12 Other studies showing a male predominance for psoriasis have been reported in Chinese and Japanese studies. [17][18][19] Types Chinese studies show that psoriasis vulgaris accounts for 82.6%-97.9% of psoriasis patients (Table 2). Pustular psoriasis, psoriasis arthropathica, and erythrodermic psoriasis account for 0.69%-2.17%, 0.69%-6.52%, and 0%-8.7%, respectively.…”

Section: Sex Distributionmentioning

confidence: 99%

“…9,11,12 The incidence of psoriasis vulgaris and pustular psoriasis in the People's Republic of China is similar to that reported in Japan (Table 3), while psoriasis arthropathica and erythrodermic psoriasis are slightly higher. 18,19 Compared to the high incidence of psoriasis arthropathica in Caucasians, accounting for 30% of psoriasis incidence, 20 the incidence of psoriasis arthropathica in Chinese patients is lower. It is also lower in Middle-Eastern and other Asian countries.…”

Section: Sex Distributionmentioning

confidence: 99%

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Epidemiology and treatment of psoriasis: a Chinese perspective

Pan¹,

Zhang²

2014

PTT

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Background: Psoriasis is a chronic inflammatory skin disease that has a negative impact on quality of life. Prevalence and management of psoriasis varies among different ethnic groups. Objectives: To evaluate the epidemiology and treatment of psoriasis from a Chinese perspective. Methods: A systematic search was performed on PubMed and the China National Knowledge Infrastructure using the following MeSH terms: "psoriasis" and ("prevalence" or "epidemiology") and "risk factor" and ("management" or "treatment"). The search included all citations from 1975 to 2013. Data were sorted by prevalence, age of onset, sex distribution, type, severity, risk factors, and management and treatment. Severity of psoriasis was classified as mild, moderate, or severe. The studies cited in this review involved Chinese subjects. Results: The prevalence of psoriasis in the People's Republic of China ranged from 0.11% to 0.47%. Genetic and environmental factors played an important role in initiation and exacerbation of psoriasis. Results showed that psoriasis can occur at any age but is more common in young and middle-aged individuals and occurs more often in men and earlier in women. Psoriasis vulgaris accounted for 82.6%-97.1% of psoriasis patients. More than 90% of patients with psoriasis were classified as mild or moderately severe. Risk factors are numerous. Management and treatment was based on classification level. Conclusion:The prevalence of psoriasis in Chinese patients is lower than that in Caucasians. A cold and dry climate, bacterial infection, diet, and stress are important risk factors for developing psoriasis. There are a variety of management and treatment options available. As such, Chinese patients with psoriasis can receive effective, safe, and individualized treatment.

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A survey of psoriasis patients in Japan from 1982 to 2001

Cited by 106 publications

References 11 publications

Identification of Susceptibility Loci for Skin Disease in a Murine Psoriasis Model

Identification of Susceptibility Loci for Skin Disease in a Murine Psoriasis Model

The prevalence of psoriasis among elderly individuals: more questions than answers

Epidemiology and treatment of psoriasis: a Chinese perspective

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