A survey of risk factors in carcinoma esophagus in the valley of Kashmir, Northern India

Na, Khan; Teli, M Ashraf; Haq, M Mohib-ul; Bhat, Gull Mohammad; Lone, Mohammad Maqbool; Afroz, Fir

doi:10.4103/0973-1482.80431

Cited by 43 publications

(38 citation statements)

References 12 publications

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“…11 Poor socio-economic status resulting in fewer intake of fruits and vegetables and fish and heavy hookah smoking are suspected to be the major risk factors for the development of esophageal cancer. 12 Drinking hot beverage over a period of time causing thermal injury leading to chronic esophagitis was strongly associated with a higher risk of esophageal cancer. 13 Various studies published previously on very high incidence of cancer esophagus in Kashmir have revealed wide spread contamination by N-nitroso compounds in raw food, salted tea prepared by adding sodium bicarbonate has shown high methanation activity and can cause endogenous formation of nitrosamines.…”

Section: Discussionmentioning

confidence: 99%

Pattern of esophageal cancer in tertiary care hospital in North India: a clinicopathological study

2017

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Background: Esophageal cancer is one of the deadliest and eighth most common cancer worldwide. It is the sixth most common cause of cancer related deaths with developing nations making up more than 80% of total cases and deaths. The purpose of this study was to assess the histopathological pattern of esophageal cancer in our region.Methods: In our centre, we analyzed 101 cases of endoscopic esophageal biopsy proven cases of esophageal cancer from January 2014 to June 2016. In most of these cases, dysphagia was the commonest indication of esophageal endoscopy.Results: 65 cases (64.4%) were males and 36 cases (35.6%) were females. Most of the patients were in the age group of 41-60 years. The histopathological analysis revealed squamous cell carcinoma as the most common esophageal cancer (n=61, 60.4%) followed by adenocarcinoma (n=38, 37.6%) and 02 cases of undifferentiated carcinoma (2%).Conclusions: Esophageal cancer is one of the commonest digestive tract malignancy in India. The males are affected more than the females with male to female ratio of 1.8:1. The maximum number of cases being seen in fifth and sixth decade of life. The squamous cell carcinoma is the most common esophageal cancer seen, with middle esophagus being the commonest site. However, the number of cases of adenocarcinoma are on rise.

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Section: Discussionmentioning

confidence: 99%

Pattern of esophageal cancer in tertiary care hospital in North India: a clinicopathological study

2017

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“…Incidence of this cancer is higher in males and rises steadily with advancing age [6,11,12]. The current study also revealed a male preponderance with 59.47% of cases in the age group of 50-70 years Table 1.The patients usually present at an advanced stage with dysphagia to solids when more than half of the lumen gets involved with the disease.…”

Section: Discussionmentioning

confidence: 63%

“…Squamous cell cancer is the most prevailing histological subtype in the endemic regions of the world, accounting more than 90% of all esophageal malignancies [2].High incidence of cancer of esophagus has been reported from Caspian littoral of Iran, central and east Asia, certain areas of China [3]. In India cancer of esophagus is the most common malignancy involving the gastrointestinal track in Karnataka, Tamil Nadu,Kerala,Assam and Kashmir [4][5][6]. Despite advances in imaging technology and treatment modalities of carcinoma esophagus,5 year survival rates for patients with localized and regional involvement remain low at 33.7 and 16.7% respectively [7].…”

Section: Introductionmentioning

confidence: 99%

Role of C - Reactive protein In Carcinoma Esophagus In Terms Of Survival And Disease Free Progression

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et al. 2017

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“…[1,2] Squamous cell carcinoma is the most prevalent histological form accounting over 90 % of cases in the endemic regions of the world. [3,4] The conventional treatment with surgery and radiation is limited with a five year survival of 10-25 % worldwide.…”

Section: Introductionmentioning

confidence: 99%

Comparison Of External Beam Radiotherapy Followed By Intra-Luminal Brachytherapy With External Beam Radiotherapy Alone In Locally Advanced Carcinoma Of Esophagus

M.M

2017

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Aim:The aim was to compare the outcome of intraluminal boost brachytherapy following external beam radiotherapy with external beam radiotherapy alone in locally advanced carcinoma esophagus in terms of toxicity, response, andsurvival. Material and Methods: A total of 80 patients with squamous cell carcinoma of esophagus were enrolled in the study between June 2014 to June 2016.Patients were treated with external beam radiotherapy (EBRT) of 40 Gy by AP/PA portals with concurrent chemotherapy. After completion of first phase of EBRT patients were divided into two groups. In Group A, boost was given by intraluminal brachytherapy (ILBT) and in Group B, boost was given by 3 field technique of EBRT. Results: Out of 80 patients, 42 were males and 38 females in the age group of 51 -70 years. After completion of treatment, residual disease was present in 60 % and 77.5 % in Group A and B respectively. Complete response was seen in 22.5 % and 15 % in Group A and B respectively. Dysphagia improvement was seen in 86.5% and 59.9 % in Group A and B respectively (P= 0.45). Median survival was 57% and 43% in Group A and B respectively. Conclusions: Dysphagia improvement, local response and median survival was better and toxicities less in Group A, as compared to Group B,

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A survey of risk factors in carcinoma esophagus in the valley of Kashmir, Northern India

Abstract: Poor socio-economic status resulting in fewer intakes of fresh fruits, vegetables and fish in addition to heavy hookah smoking are suspected to be the major risk factors for the development of esophageal cancer.

Cited by 43 publications

References 12 publications

Pattern of esophageal cancer in tertiary care hospital in North India: a clinicopathological study

Pattern of esophageal cancer in tertiary care hospital in North India: a clinicopathological study

Role of C - Reactive protein In Carcinoma Esophagus In Terms Of Survival And Disease Free Progression

Comparison Of External Beam Radiotherapy Followed By Intra-Luminal Brachytherapy With External Beam Radiotherapy Alone In Locally Advanced Carcinoma Of Esophagus

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