2018
DOI: 10.1021/acs.jmedchem.8b01610
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A Survey of the Structures of US FDA Approved Combination Drugs

Abstract: Combination drugs are an important class of US FDA approved pharmaceuticals. These drugs have been on a continuous growth trajectory since the first combination drugs were approved in the 1940s. In this Perspective, we report the first comprehensive compilation and analysis of US FDA approved combination drugs, from the first approval in 1943 through 2018. Our database contains 419 combination drugs, which are represented by 328 unique small molecule structures. Breakdown of these drugs according to disease ca… Show more

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Cited by 213 publications
(126 citation statements)
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“…Nucleoside reverse transcriptase inhibitors (NRTIs) are commonly administered with other drugs in highly active antiretroviral therapy (HAART) to target multiple stages of the HIV life cycle. Lamivudine and tenofovir are among the most important drugs used in combination (Das et al, 2019). According to a survey, among the top 24 small-molecule combinations most frequently utilized as drug components, anti-HIV lamivudine occurred 15 times, while tenofovir disoproxil occurred 9 times.…”
Section: Introductionmentioning
confidence: 99%
“…Nucleoside reverse transcriptase inhibitors (NRTIs) are commonly administered with other drugs in highly active antiretroviral therapy (HAART) to target multiple stages of the HIV life cycle. Lamivudine and tenofovir are among the most important drugs used in combination (Das et al, 2019). According to a survey, among the top 24 small-molecule combinations most frequently utilized as drug components, anti-HIV lamivudine occurred 15 times, while tenofovir disoproxil occurred 9 times.…”
Section: Introductionmentioning
confidence: 99%
“…To assess our deep generative model for drug combination design (to be detailed in Sec. 3.2), we consider a comprehensive list of US FDAapproved combination drugs (1940-2018.9) (Das et al, 2018). The dataset contains 419 drug combinations consisting of 328 unique drugs, including 341 (81%), 67 (16%) and 11 (3%) of double, triple and quadruple drug combinations.…”
Section: Fda-approved Drugs and Drug Combinationsmentioning
confidence: 99%
“…Syntheses of nitrogen-containing fused heterocyclic small molecules are attracting increasing attention in medicinal chemistry, drug design, and advanced materials due to their structural complexities. [1][2][3][4] These architecturally complex molecules are frequently used as biological probes in living systems as well as drugs in medicine because their diverse heteroatoms can bind different locations of biological macromolecules. Researchers in pharmaceutical industries and academicians are highly interested in the synthesis of fused heterocyclic small molecules owing to their pharmaceutical activities and therapeutic potential.…”
Section: Introductionmentioning
confidence: 99%
“…Phenylbenzo[d]imidazo[2,1-b]thiazole (3a)28 Yield: 95%, white solid; mp: 88-90 C, R f : 0.5% (40% EtOAc/n-Hexane);1 H NMR (400 MHz, CDCl 3 ) 7.87 (s, 1H), 7.79 (d, J ¼ 7.52 Hz, 2H), 7.60 (d, J ¼ 7.96 Hz, 1H), 7.50 (d, J ¼ 8.0 Hz, 1H), 7.37-7.32 (m, 3H), 7.24-7.18 (m, 2H); 13 C NMR (100 MHz, Scheme 4 A plausible mechanism for the syntheses of benzo[d]imidazo[2,1-b]thiazole derivatives. This journal is © The Royal Society of Chemistry 2020 RSC Adv., 2020, 10, 770-778 | 775 Paper RSC Advances Open Access Article.…”
mentioning
confidence: 99%