A Survey of Therapeutic Effects of<i>Artemisia capillaris</i>in Liver Diseases

Jang, Eungyeong; Kim, Bum Joon; Lee, Kyung Tae; Inn, Kyung Soo; Lee, Jang Hoon

doi:10.1155/2015/728137

Cited by 61 publications

(43 citation statements)

References 70 publications

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“…Studies also indicated that Cap suppressed cancer cell proliferation, survival, and invasion in estrogen‐positive breast carcinoma MCF‐7 cells, B‐lymphoblast cells, and osteosarcoma cells . So far, at the therapeutic dose of Cap, no undesirable side effects or toxicity reported clinically . However, the anti‐cancer effect of Cap on prostate carcinoma cells and the mechanism of Cap targeting on androgen‐dependent AR remain unexplored.…”

Section: Introductionmentioning

confidence: 99%

“…11 Capillarisin (Cap) is an active component extracted from Artemisia capillaris, in which its young shoots being consumed as vegetables and the whole plant used as an herbal remedy for various inflammatory diseases, such as hepatitis, jaundice cholestasis, and urinary tract infections in Asia. 12 Cap has been reported with anti-inflammatory properties through mediating NFκ-B and MAPKs signaling pathways in vitro and in vivo, [13][14][15][16] and with antioxidant characteristics in primary hepatocytes. 17,18 Studies also indicated that Cap suppressed cancer cell proliferation, survival, and invasion in estrogen-positive breast carcinoma MCF-7 cells, 19 B-lymphoblast cells, 20 and osteosarcoma cells.…”

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confidence: 99%

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Capillarisin blocks prostate‐specific antigen expression on activation of androgen receptor in prostate carcinoma cells

et al. 2017

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Section: Introductionmentioning

confidence: 99%

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confidence: 99%

Capillarisin blocks prostate‐specific antigen expression on activation of androgen receptor in prostate carcinoma cells

et al. 2017

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“…Because AC has been widely used as a medicinal plant for the treatment of liver diseases (Jang et al, ), herein, we used a newly prepared ethanol extract (ACE‐63) from AC and investigated whether ACE‐63 has anticancer efficacy in HCC. Recently, natural plants have been suggested to have potential as new drugs, which may exhibit chemoprotective activity via induction of apoptosis in cancers (Taneja and Qazi, ).…”

Section: Discussionmentioning

confidence: 99%

An ethyl acetate fraction of Artemisia capillaris (ACE‐63) induced apoptosis and anti‐angiogenesis via inhibition of PI3K/AKT signaling in hepatocellular carcinoma

Jung

Rumman

Yan

et al. 2018

Phytotherapy Research

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In cancer treatment, herbal medicines may be a good choice because of the reduced risk of adverse side effects. Artemisia capillaris has been recognized as a promising candidate due to its hepatoprotective effects. Herein, we investigated whether A. capillaris-derived fraction (ACE-63) could inhibit the progression of hepatocellular carcinoma (HCC) and its underlying mechanism. In this study, ACE-63 effectively inhibited the growth and proliferation of HCC cells. ACE-63 induced apoptosis, as observed using Terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) staining, which was accompanied with increases in cleaved Poly (ADP-ribose) polymerase (PARP) and caspase-3 in HCC cells. Additionally, the pro-apoptotic effect of ACE-63 was demonstrated by a decrease in the expression of the X-linked inhibitor of apoptosis protein (XIAP) and survivin via a loss of mitochondrial membrane potential. In an ex vivo model, ACE-63 significantly inhibited tumor cell growth and induced apoptosis by increasing the expression of cleaved caspase-3 and DNA fragmentation. In addition, ACE-63 decreased the expression of hypoxia-inducible factor-1α and vascular endothelial growth factor and inhibited tube formation of human umbilical vein endothelial cells. A mechanistic study revealed that ACE-63 effectively suppressed the PI3K/AKT/mTOR signaling pathways, which were observed as a target signaling by phosphokinase array. Taken together, our findings demonstrate that ACE-63 could not only efficiently induce apoptosis but also inhibit the growth/angiogenesis of human HCC cells by blocking the PI3K/AKT/mTOR signaling pathway, suggesting that ACE-63 may be a new chemotherapeutic candidate against HCC.

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“…D-Limonene is metabolized to perillyl alcohol, which inhibits G-protein isoprenylation [26]. Artemisia capillaris (wormwood), which is known to inhibit CNE-2 nasopharyngeal carcinoma, DMBA induced breast cancer, SMMC-7721 human hepatoma, HL-60 leukemia, HepG2, Huh-7 human liver cells, HeLa cervical cancer, and mouse liver cells, contains borneol, which is also a constituent of cardamom [28,78]. Borneol is anti-oxidative, cytotoxic, DNA-damaging, and DNA-protective to Caco-2 and VH10 [28].…”

Section: Whole Plant Nutraceuticals Cardamonmentioning

confidence: 99%

Nutraceuticals: Curative Integrative Cancer Treatment

Nwanodi¹

2017

Altern Integr Med

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Statement of Purpose: Although 75% of breast cancer patients may use integrative medicine, only 11.5% earlystage breast cancer patients believe integrative medicine has anticancer activity. The gap in users of and firm believers in integrative medicine indicates a need to increase awareness of integrative medicine's applicability to curative cancer treatment. As diet, nutraceuticals, and traditional Chinese medicine are used by up to 82% of cancer patients who use integrative medicine, this paper focuses on nutraceuticals. As female cancer patients are most likely to use integrative medicine, nutraceuticals specific to breast, cervical, endometrial, and ovarian cancer are reviewed.Methods: PubMed searches in September 2016 and January 2017, and accompanying hand searches were performed for English language, free full text articles published from 2012 onwards. Search terms were combinations of the key words: Homeopathy, phytochemicals, breast cancer, cervical cancer, endometrial cancer, ovarian cancer, cancer, prevention, treatment. Curative nutraceutical treatments were taken from these searches. Supplemental hand searches were performed as needed. Findings:Integrative nutraceutical therapies are based on biologic plausibility. Individual nutraceuticals are frequently comprised of numerous phytochemical types, and have multiple mechanisms of action. Agonistantagonist mechanisms are not exclusive to phytoestrogens, complicating which derivative or whole nutraceutical to use. Research on breast and cervical cancer inhibitors has seemingly outpaced that for endometrial and ovarian cancer. Breast cancer inhibitors include terpenes, isoflavones, organosulphurs, organoselenium compounds, and withanolides. Conclusion and Significance:Potential nutraceutical candidates for curative cancer treatment abound. Discerning which constituents, which extraction method, and which delivery method to use for an efficacious treatment is an essential, lengthy process. If nutraceuticals such as limonene and Kahalalide F move forward to Phase III trials a nutraceutical cancer treatment pipeline may be established. Withaferin-A and derivatives for breast and ovarian cancer appear to be the leading gynecologic cancer nutraceutical drug candidates.

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A Survey of Therapeutic Effects ofArtemisia capillarisin Liver Diseases

Cited by 61 publications

References 70 publications

Capillarisin blocks prostate‐specific antigen expression on activation of androgen receptor in prostate carcinoma cells

Capillarisin blocks prostate‐specific antigen expression on activation of androgen receptor in prostate carcinoma cells

An ethyl acetate fraction of Artemisia capillaris (ACE‐63) induced apoptosis and anti‐angiogenesis via inhibition of PI3K/AKT signaling in hepatocellular carcinoma

Nutraceuticals: Curative Integrative Cancer Treatment

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