A Survey Study of Pregnant Women and Healthcare Practitioners Assessing the Knowledge of Attitudes and Practices of Hepatitis B Management at a Teaching Hospital in Kumasi, Ghana, West Africa

Cheng, Anita; Jose, JoAnn; Larsen-Reindorf, Roderick; Small, Christina M.; Nde, H.; Dugas, Lara R.; Ehrhardt, Stephan; Nelson, Kenrad E.; Ezeanolue, Echezona E.; Layden, Jennifer E.

doi:10.1093/ofid/ofv122

Cited by 15 publications

(13 citation statements)

References 9 publications

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“…For instance, Mutocheluh and Kwarteng [ 62 ], reported that among 200 barbers in Kumasi none (0 %) of the barbers could describe the common HCV transmission pathways and only 7 % were aware that sharing razor blade or hair trimmer could be a means of transmitting viral pathogens like HCV and HBV. Similar trends of low awareness has been reported for pregnant women [ 63 ]. Additionally, while the transmission dynamics of HCV remains varied and include unprotected sex, mother-to-child transmission and transfusion of infected blood, in many Ghanaian communities, there has been an over-emphasis on HCV and related viral hepatitis as sexually transmitted infections (STIs) [ 13 ].…”

Section: Discussionsupporting

confidence: 85%

Epidemiology of hepatitis C virus in Ghana: a systematic review and meta-analysis

Agyeman¹,

Ofori‐Asenso²,

Mprah³

et al. 2016

BMC Infect Dis

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BackgroundTo fully understand the burden of hepatitis C (HCV) infection in Ghana towards informing appropriate preventive measures, accurate prevalence estimates are needed. In this study, we estimate the prevalence of chronic HCV infection by systematically reviewing primary studies published between 1995 and 2015.MethodsA systematic review and meta-analysis was conducted as per the PRISMA guidelines. Comprehensive searches for hepatitis C prevalence studies for the years 1995–2015 were conducted in PubMed, ScienceDirect, Google Scholar, Africa Journals Online (AJOL) and the WHO African Index Medicus databases. We also searched the websites of the ministry of health and Ghana Health service for non-indexed studies or reports on the subject. Further systematic reference screening of published reviews and retrieved studies were also conducted to identify additional publications not captured through the online searches.ResultsTwenty-Four (24) studies from nine regions of Ghana with a combined sample size of 100,782 were analyzed. No study involving participants from Upper West region was retrieved. The national prevalence of chronic HCV was estimated as 3.0 % (95 % CI = 2.6 % to 3.5 %; I2 = 97.61 %, p < 0. 001). Prevalence rates of chronic HCV infection among blood donors was 2.6 % (95 % CI = 2.1 % to 3.1 %; I2 = 98.33 %, p < 0.001) with higher prevalence rate estimated for replacement blood donors (RBDs) than voluntary blood donors (RBDs). Among pregnant women and parturients, anti-HCV seroprevalence was estimated as 4.6 % (95 % CI = 1.8 % to 7.5 %; I2 = 75.74 %, p = 0.016). The national prevalence of HIV/HCV co-infection was also estimated as 2.8 % (95 % CI = 0.4-6 %; I2 = 65.86 %, p = 0.0053). Regional prevalence of chronic HCV infection were determined for Ashanti (1.5 %, 95 % CI = 1.2 % to 1.9 %; I2 = 96.24 %, p < 0.001) and Greater Accra (6.4 %, 95 % CI = 4.2 % to 8.6 %; I2 = I2 = 88.5 %, P < 0. 001) regions but no estimates were available for the other eight regions. The ascending order of HCV prevalence rates according to years in which studies were conducted was 2006–2010 < 2011–2015 < 1995–2002 < 2001–2005. Higher prevalence of chronic HCV infection was estimated for rural (5.7; 95 % CI 5.0–6.3 %; I2 = 0, p = 0.804) than urban (2.6 %, 95 % CI = 2.1 % to 3.0 %; I2 = 97.3 %, p = 0.0001) settings.ConclusionOur study demonstrates a high prevalence of chronic hepatitis C infection in Ghana. This highlights the urgent need for stronger commitments from government and all stakeholders within the country to outline efficient preventive and curative measures towards reducing the overall burden of the disease.

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Section: Discussionsupporting

confidence: 85%

Epidemiology of hepatitis C virus in Ghana: a systematic review and meta-analysis

Agyeman¹,

Ofori‐Asenso²,

Mprah³

et al. 2016

BMC Infect Dis

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“…The high rate of willingness to take HBV vaccination discovered in the study was in line with the finding from a Ghana study showing that 93.8% of pregnant women surveyed would take medication to prevent HBV [17]. In contrast, a Chinese study stated that only 16.5% of participants would accept HBV preventive drugs during pregnancy [18].…”

Section: Discussionsupporting

confidence: 78%

Knowledge, Preference, and Willingness to Pay for Hepatitis B Vaccination Services among Woman of Reproductive Age in Vietnam

Nguyen

Thi

et al. 2019

BioMed Research International

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Background. Hepatitis B virus (HBV) vaccine is a critical approach to prevent HBV transmission from mother to child. However, despite high HBV prevalence, evidence about the preference of women of productive age for HBV vaccine in Vietnam was constrained. This study aims to explore the preference and willingness to pay (WTP) for the HBV vaccine in Vietnamese women in productive age. Methods. A cross-sectional study was conducted in Hanoi in April 2016. A structured questionnaire was used to collect information about respondents’ socioeconomic status and knowledge about HBV vaccination. A contingent valuation approach was employed to measure the WTP for the HBV vaccine. Logistic and interval regressions were used to determine the associated factors. Results. Among 807 women, 80.8% were willing to have the vaccine injected which had the average price of 108,600 VND (95% CI, 97,580 VND–119,570 VND). Participants not suffering any diseases during pregnancy were more likely to be willing to pay for the HBV vaccine (OR = 3.41, 95% CI = 1.73–6.70). Not having the antenatal examination at central hospitals and working as farmers/workers were positively correlated with willingness to pay for this vaccine, while the number of children of respondents had a negative correlation with WTP. Conclusions. Our sampled women expressed a high willingness to pay for the vaccine. The price people were willing to pay for the vaccine, however, is equal to half of the actual price. These findings implied needs for better targeted public education interventions about HBV and the involvement of local medical staffs and the media in providing information. Efforts to reduce the price of the vaccine should also be warranted for scaling-up the coverage of this vaccine.

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“…Fourteen included studies assessed the awareness of 9,446 Africans in regard to HBV, three studies were conducted in each of Nigeria [61,62,64] , Cameroon [20,40,58] and Ghana [12,15,28] , two in Ethiopia [32,52] , one in each of Kenya, Mozambique and Madagascar [26,57,71] . The oldest among the study included was conducted in 2010 while the newest was conducted in 2016 (Table 1).…”

Section: Resultsmentioning

confidence: 99%

Knowledge Gaps of STIs in Africa; Systematic review

Suluiman¹,

SalahEldin

Idris

et al. 2019

Preprint

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30Sexually Transmitted Infections (STIs) are ambiguous burden of tremendous health, social and 31 economic consequences, The current systematic review was conducted in order to determine 32 awareness and knowledge of Africans of sexually transmitted infections, not only concerning 33 HIV/AIDS, but also other STIs such as, gonorrhea, syphilis, HBV, HCV and HPV. A systematic 34 review of the literature was conducted, studies were retrieved and selected after they fulfilled the 35 inclusion criteria and passed the assessment procedure. related data was extracted, quantitative 36 analysis was conducted among participants who responded to questions related to HIV, HBV, HCV, 37 HPV or STIs knowledge, sensitivity analysis as well as subgroup analysis were also conducted. 38 Seventy four articles addressing knowledge among 35 African countries were included and 136 39 questions were analyzed and synthesized. The question Using condom will reduce HIV 40 transmission?'' was answered by 1,799,374 Africans in 35 countries, 66.82% [95% Cl; 62.65, 70.98] 41 answered yes. While the question ''Is sexual contact a possible route of HBV transmission?'' was 42 answered by 7,490 participants in 5 countries; 42.58% [95% Cl; 20.45, 64.71] answered yes. The 43 differences observed among populations are highlighting the possibility for containment and control 44 by directing light toward specific populations or countries as well as addressing specific awareness 45 knowledge to ensure that the general as well as the related specific preventive awareness knowledge 46 is improved. 47 Introduction 50 Sexually transmitted Infections (STIs) are ambiguous burden of tremendous health, social and 51 economic consequences. Most of them are hidden because many people may feel stigmatized when 52 addressing them. Moreover, the committee on prevention and control of sexually transmitted diseases 53 in USA estimated that the annual costs of selected major STDs are approximately $10 billion or, if 54 sexually transmitted HIV is included, $17 billion [1] . 55 According to UNAIDS; almost 37 million people globally were living with HIV in 2017, sub-Saharan 56 Africa accounted for 66% of the cases, 68% of new adult HIV infections, 92% of new infections in 57 children and 72% of all AIDS-related deaths. Earlier in 2009, Swaziland topped the world's HIV 3 58epidemic countries with a 26% prevalence among adults, while South Africa was the country with the 59 world's largest prevalence of people living with HIV as 5.6 million [2,3] . 60On the other hand and according to WHO; an estimated 257 million people are living with HBV 61 infection with the highest prevalence in the Western Pacific Region and the African Region as 6.2% 62 and 6.1% of the adult population are infected, respectively. About 1% of persons living with HBV 63 infection (2.7 million people) are also infected with HIV. Moreover, approximately 399,000 people 64 89 exception was if the collection process continued months/years earlier than 2010 and ended in 2010 or 90 afterwards. The keyw...

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A Survey Study of Pregnant Women and Healthcare Practitioners Assessing the Knowledge of Attitudes and Practices of Hepatitis B Management at a Teaching Hospital in Kumasi, Ghana, West Africa

Cited by 15 publications

References 9 publications

Epidemiology of hepatitis C virus in Ghana: a systematic review and meta-analysis

Epidemiology of hepatitis C virus in Ghana: a systematic review and meta-analysis

Knowledge, Preference, and Willingness to Pay for Hepatitis B Vaccination Services among Woman of Reproductive Age in Vietnam

Knowledge Gaps of STIs in Africa; Systematic review

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