Ti-6Al-4V, the most commonly used alloy of titanium, possesses excellent mechanical properties and corrosion resistance, which is the prime reason for the continual rise in its industrial demand worldwide. The extraordinary mechanical properties of the alloy are viewed as a hindrance when it comes to its shaping processes, and the process of milling is no exception to it. The generation of intense heat flux around the cutting zones is an established reason of poor machinability of the alloy and unacceptably low sustainability of its machining. The work presented in this paper attempts to enhance sustainability of milling Ti-6Al-4V by investigating the effects of milling orientation, cutter's helix angle, cutting speed, and the type of cryogenic coolant and lubricant on the sustainability measures, such as tool damage, cutting energy consumption, process cost, milling forces, and work surface roughness. It was found that micro-lubrication is more effective than the two commonly used cryogenic coolants (carbon dioxide snow and liquid nitrogen) in reducing tool wear, work surface roughness, process cost, and energy consumption. Furthermore, down-milling enormously outperformed up-milling with respect to tool wear, work surface quality, and process cost. Likewise, the high levels of cutter's helix angle and cutting speed also proved to be beneficial for milling sustainability.Metals 2020, 10, 258 2 of 25 environmentally [3]. The problem is generally negotiated either by lowering the material removal rates or by applying emulsion-based coolants, neither of which actually offers a sustainable solution.With regard to quashing the intense heat flux around the cutting areas, the application of cryogenic fluids, especially liquid nitrogen (LN 2 ), fares very well. The fluids offer a viable solution because of extremely low operational temperatures, no waste generation, and controllable flow rates. Additionally, application of micro-lubrication, also known as minimum quantity of lubrication (MQL), also proved to be very beneficial in enhancing tool life and improving surface quality in machining of titanium alloys conducted at medium cutting speeds [4,5]. MQL is a near-dry machining method in which a miniscule quantity of lubricating oil is pulverized into a stream of air, and the resulting aerosol is applied onto the cutting areas [6].Although steady progress is being made regarding quantification of the effects of cryogenic coolants with regard to the continuous machining processes, not much effort is being put up concerning interrupted machining processes, such as milling. Cryogenic milling is distinct from continuous machining processes performed under cryogenic environment in the sense that the cutting teeth of a milling tool periodically and rapidly engage and disengage with the work material, leading to cyclic heating (caused by thermal energy released by work material's plastic deformation) and cooling (caused by interaction with the incoming cryogenic fluid) of the cutting edges. Such a course is expected to induce...