A “Swingable” straight-chain affinity molecule immobilized on a semi-conductor electrode for photo-excited current-based molecular sensing

Takatsuji, Yoshiyuki; Wakabayashi, Ryo; Sakakura, Tatsuya; Haruyama, Tetsuya

doi:10.1016/j.electacta.2015.08.111

Cited by 4 publications

(3 citation statements)

References 31 publications

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“…A plethora of important chemical sensors that have immense significance in the wearables market mandates bioaffinity assays. For example, the detection of a wide variety of physiologically relevant biomarkers depends on bioaffinity based sensors. − Similarly, environmental sensors for detecting toxic chemicals , and chemical warfare agents , require bioaffinity receptors. The development of reliable wearable formats of such bioaffinity sensors has the potential to radically change the landscape of the wearable chemical sensors field.…”

Section: Present Challenges and Possible Solutionsmentioning

confidence: 99%

Wearable Chemical Sensors: Present Challenges and Future Prospects

2016

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Wearable sensors have received considerable interest over the past decade owing to their tremendous promise for monitoring the wearers' health, fitness, and their surroundings. However, only limited attention has been directed at developing wearable chemical sensors that offer more comprehensive information about a wearer's well-being. The development of wearable chemical sensors faces multiple challenges on various fronts. This perspective reviews key challenges and technological gaps impeding the successful realization of effective wearable chemical sensor systems, related to materials, power, analytical procedure, communication, data acquisition, processing, and security. Size, rigidity, and operational requirements of present chemical sensors are incompatible with wearable technology. Sensor stability and on-body sensor surface regeneration constitute key analytical challenges. Similarly, present wearable power sources are incapable of meeting the requirements for wearable electronics owing to their low energy densities and slow recharging. Several energy-harvesting methodologies have inherent issues, including inconsistent power supply and limited stability. There are also major challenges pertaining to handling and securing the big data generated by wearable sensors. These include achieving high data transfer rates and efficient data mining. Efforts must also be made toward developing next generation cryptologic algorithms for ensuring data security and user privacy. The challenges facing the field of wearable chemical sensors, and wearable sensors, in general, can thus be addressed only by a multidisciplinary approach where researchers from diverse fields work in unison. The article discusses these challenges and their potential solutions along with future prospects.

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Section: Present Challenges and Possible Solutionsmentioning

confidence: 99%

Wearable Chemical Sensors: Present Challenges and Future Prospects

2016

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“…98 mm 3 inner volume (5 mm¯© 5 mmH), and measurements were performed in a closed system at room temperature. A laser diode emitting light at 532 nm with a beam diameter of ca.…”

Section: Pas Measurementsmentioning

confidence: 99%

“…Regarding the swingable molecular layer, we have reported on the immobilized enzyme 2 and the affinity sensor using photoexcited current. 3 Charge transfer efficiency i.e., electron transfer, is dependent on the distance through which the electron must travel. In this study, the swingable function of an immobilized molecule and the efficiency of excited electron transfer by photo-irradiation were shown by comparing rigid and flexible linkers.…”

Section: Introductionmentioning

confidence: 99%

Smooth Electron Transfer from a Photoexcited Dye to Semiconductor Electrode Through a Swingable Molecular Interface

et al. 2016

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The transfer of photoexcited electrons from a fluorescent dye molecule to a semiconductor electrode is regulated by the interfacial design between the electrode and the dye. In the case of larger functional molecules, the regulation becomes observable because of molecular steric hindrance on the solid electrode surface. We have studied the effectiveness of a "swingable" functional molecule layer on a solid substrate for immobilized catalysts and electrochemical reactions. The swingable molecular interface offers the possibility of a similar outcome in photoexcited current generation. The swingable design of the molecular layer may allow smooth current flow from the dye to the semiconductor electrode, because the dye molecules come in close proximity to the semiconductor surface through the swinging action of the linker molecules. In the present study, FTO (fluorinedoped tin oxide) electrodes were prepared with two types of dye-tagged molecular layers, differing only in the type of linker between the dye and the FTO surface: one with a flexible peptide linker capable of swinging back and forth and around, and the other with a rigid peptide linker. The two dye-sensitized FTO electrodes were assayed using photoexcited current measurements. As per the experimental results, the FTO electrode modified with the swingable linker molecule produced higher photoexcited current than that of the FTO modified with the rigid molecule linker.

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Promoting of direct electron transfer of multicopper oxidase by control of enzyme molecule density on multi-walled carbon nanotube

et al. 2020

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In order to improve the performance of direct electron transfer-type electrode using multicopper oxidase (MCO), it is important to shorten the distance between the redox site of the enzyme and the electrode surface to increase electron transfer efficiency between enzyme and electrode. In this study, we focused on the mobility of the MCO from hyperthermophilic archaeon, Pyrobaculum aerophilum, immobilized onto electrode surface via an affinity tag at the MCO terminus. The mobility of the immobilized enzyme was controlled by changing the density of the immobilized enzyme on the electrode surface by altering the density of the linker for enzyme immobilization. The electrode with low density of MCO immobilized on electrode surface was improved swing ability of the enzyme. It showed 265% higher current density for electrochemical O2 reduction than that with high density of MCO immobilized on electrode surface. Biofuel cell using a cathode with a low density of MCO immobilized on the electrode showed 160% higher power density than a biofuel cell using a cathode with a high density of MCO immobilized on the electrode.

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A “Swingable” straight-chain affinity molecule immobilized on a semi-conductor electrode for photo-excited current-based molecular sensing

Cited by 4 publications

References 31 publications

Wearable Chemical Sensors: Present Challenges and Future Prospects

Wearable Chemical Sensors: Present Challenges and Future Prospects

Smooth Electron Transfer from a Photoexcited Dye to Semiconductor Electrode Through a Swingable Molecular Interface

Promoting of direct electron transfer of multicopper oxidase by control of enzyme molecule density on multi-walled carbon nanotube

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