A switchable electrochemical redox ratiometric substrate based on ferrocene for highly selective and sensitive fluoride detection

Abstract

A ferrocene based electrochemical redox substrate for highly selective and sensitive fluoride detection in non-transparent solutions.

Crystal structure of 2-((tert-butyldimethylsilyl)oxy)-5-methylisophthalaldehyde, C15H22O3Si

“…This protecting group can be removed by reaction with a fluoride anion. Therefore, compounds with TBS are widely used in the design and synthesis of probes for fluoride anion detection [16][17][18][19]. Within this perspective and our continuing research efforts, we report the crystal structure of the title compound.…”

Ratiometric Electrochemistry: Improving the Robustness, Reproducibility and Reliability of Biosensors

“…An LOD of 0.4 U mL −1 was reported, and the FcCD was compatible with enzyme linkedimmunosorbent assays (ELISAs), allowing for the potential incorporation of the substrate into multiple sensing platforms. This strategy has proved near universal, with further enzyme substrates [145,146] small molecules [147][148][149][150], and metal ions [151]. A different strategy was developed by Zhao et al, where a single substrate contained two separate electroactive units [152].…”

An Organophosphorus(III)-Selective Chemodosimeter for the Ratiometric Electrochemical Detection of Phosphines

“…Inspired by trigger-linker-effector methodology [23,24], benzyl ferrocenylcarbamates have been effectively employed for the ratiometric electrochemical detection of both enzymes, such as β-galactosidase and alkaline phosphatase [25,26], and small molecules, such as fluoride and hydrogen peroxide [27,28]. To achieve our objective of developing a molecular probe for organophosphorus(III) species, we designed benzyl ferrocenylcarbamate 1 with a 4-azido trigger to allow for the chemoselectivity for the target to be attained through a Staudinger reaction.…”