2024
DOI: 10.2174/1574892818666230417093208
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A Synergistic Combination of Oleanolic Acid and Apatinib to Enhance Antitumor Effect on Liver Cancer Cells and Protect against Hepatic Injury

Abstract: Background: As a pentacyclic triterpenoid, OA (oleanolic acid) has exhibited anti-inflammatory, immunomodulatory and antitumor effects. VEGFR-2 (vascular endothelial cells receptor-2) tyrosine kinase activity could be inhibited by apatinib, a small-molecule anti-angiogenic agent. Thus, this study sought to investigate the mechanism underlying the synergistic anti-tumor activity of combined OA and apatinib. Materials and Methods: Through CCK8 (Cell counting kit 8 assay), flow cytometric and western blotting t… Show more

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