A Synopsis of Cousinia sect. Serratuloides (Asteraceae) in Iran

Attar, Farideh; Ghahreman, Ahmad; Mahdigholi, Kazem; Sheidai, Masoud

doi:10.3417/1055-3177(2007)17[1:asocss]2.0.co;2

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“…The genus Cousinia is the largest genus of Asteraceae and comprises about 650 species around the world (Mehregan and Kadereit, ). Most of these species are mainly found in central and south west of Asia (Attar et al ., ). The genus comprises of 210 species in Iran from which 172 species are endemic to the country (Emami and Aghazari, ).…”

Section: Introductionmentioning

confidence: 99%

Highly Oxygenated Sesquiterpene Lactones fromCousinia aitchisoniiand their Cytotoxic Properties: Rhaserolide Induces Apoptosis in Human T Lymphocyte (Jurkat) Cells via the Activation of c-Junn-terminal Kinase Phosphorylation

et al. 2015

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Infrared-guided chromatographic fractionation of sesquiterpene lactones from the extracts of Cousinia aitchisonii and Cousinia concolor led to the isolation of five pure compounds. A new sesquiterpene lactone, namely, aitchisonolide, and two known sesquiterpene lactones (desoxyjanerin and rhaserolide) were isolated from C. aitchisonii and two known lignans (arctiin and arctigenin) from C. concolor. The structures of these compounds were elucidated by one-dimensional and two-dimensional nuclear magnetic resonance techniques, as well as high-resolution mass spectrometry. The purified and characterized compounds were subjected to cytotoxicity assay. The sesquiterpene lactones desoxyjanerin and rhaserolide showed significant cytotoxic activities against five different cancer cell lines and the normal human embryonic kidney cell line. Rhaserolide was chosen to evaluate the possible mechanism of action. Western blot analysis revealed that rhaserolide could induce apoptosis in Jurkat cells via the activation of c-Jun n-terminal kinase phosphorylation.

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Section: Introductionmentioning

confidence: 99%