This paper presents the results of an investigation on the suitability of using hull panels with alternating fixed and floating frames for a 30–40 knot aluminum catamaran ferry. A prototype 4.6 m × 1.8 m bottom hull panel with alternating frames is analyzed numerically and physically tested. The corresponding finite-element analyses and test results are in good agreement. The results show that the floating frame hull panel design is a feasible structure for an aluminum catamaran. The floating frame structure was then used for a 33-knot, 250-passenger aluminum catamaran ferry designed to meet the ABS High Speed Craft rules. A midship section of the catamaran hull was analyzed using the finite-element method. Catamaran weight estimates, heave and pitch motions, and powering estimates are also provided. The results show that the alternating floating frame structure was within the ABS rules stress allowables.