A synthetic approach towards drug modification: 2-hydroxy-1-naphthaldehyde based imine-zwitterion preparation, single-crystal study, Hirshfeld surface analysis, and computational investigation

Abstract

This work is about the modification of pyrimethamine and 4-amino-N-(2,3-dihydrothiazol-2-yl)benzenesulfonamide via condensation reaction with 2-hydroxy-1-naphthaldehyde to produce new organic zwitterionic compounds DSPIN and ACPIN in methanol.