2004
DOI: 10.1359/jbmr.0301263
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A Synthetic Peptide Fragment of Human MEPE Stimulates New Bone Formation In Vitro and In Vivo

Abstract: Matrix extracellular phosphoglycoprotein (MEPE) was proposed as a candidate for the phosphaturic hormone phosphatonin. We found that a synthetic peptide fragment of MEPE containing the RGD and SGDG sequence stimulated new bone formation in vitro and in vivo.Introduction: Matrix extracellular phosphoglycoprotein (MEPE) was recently identified as a candidate for the phosphaturic hormone phosphatonin, which has been implicated in disturbed phosphate metabolism, rickets, and osteomalacia associated with X-linked h… Show more

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Cited by 59 publications
(55 citation statements)
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“…Hayashibara et al [2004] has reported that AC-100 has anabolic effects on bone and we confirm that in this study using different in vitro Fig. 3.…”
Section: Discussionsupporting
confidence: 90%
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“…Hayashibara et al [2004] has reported that AC-100 has anabolic effects on bone and we confirm that in this study using different in vitro Fig. 3.…”
Section: Discussionsupporting
confidence: 90%
“…However, Gowen et al [2003] reported that mice with targeted disruption of mepe, the product of which they have named OF45, have increased bone formation, decreased age-related trabecular bone loss, and form significantly more mineralized nodules ex vivo. It is unclear, at present, how to reconcile our findings and those of Hayashibara et al [2004] with those of Gowen et al [2003]. Given the complex nature of mineral metabolism, it is possible that several regulatory mechanisms to be involved.…”
Section: Discussionmentioning
confidence: 82%
“…However, recent studies have found that given domains of MEPE protein have different biological functions. Rowe et al reported that a small peptide released from COOHterminus of MEPE was able to inhibit mineralization processes in vitro (60) whereas another fragment from N-terminal MEPE with RGD motif accelerated mineralization (61). In this study, we identified the three major fragments of MEPE polypeptides in the mouse odontoblastic cells.…”
Section: Discussionmentioning
confidence: 70%
“…Recently, it has been shown that a truncated form of MEPE, which has the ASARM peptide removed, can promote bone mineralisation in culture and in mice (Sprowson et al 2008). Furthermore, a mid-terminal fragment of MEPE (termed 'AC100') has been shown to enhance cell binding, through the stimulation of focal adhesion kinase and ERK (Hayashibara et al 2004). Taken together, these results highlight the importance of post-translational processing in determining the functional role of MEPE.…”
Section: Matrix Extracellular Phosphoglycoproteinmentioning
confidence: 95%