A Synthetic Route to Access Allyl-methyl-N-pantothenamide via [2,3]-Wittig Rearrangement

Abstract

化的甲酸还原构建了其分子骨架, 以 10 步反应制备了 1.

Asymmetric Organocatalytic [2,3]‐Wittig Rearrangement of Cyclohexanone Derivatives

“…The [2,3]-Wittig rearrangement has been widely exploited as a key reaction for the synthesis of different biologically active compounds. [3][4][5][6][7][8][9] Despite its widespread use, the number of asymmetric catalytic methods is still limited. [10] Our group previously reported an asymmetric [2,3]-Wittig rearrangement of oxindole, malonate and cyclopentanone derivatives, in addition to an example of a diastereoselective [2,3]-sigmatropic rearrangement of N-allyl ammonium ylides.…”

“…The reaction is induced by a base and the transition state leads to the cleavage of the C−O bond and to the formation of a new C−C bond (Scheme 1). The [2,3]‐Wittig rearrangement has been widely exploited as a key reaction for the synthesis of different biologically active compounds [3–9] . Despite its widespread use, the number of asymmetric catalytic methods is still limited [10] .…”