A syringotropic variant of cutaneous sarcoidosis: Presentation of 3 cases exhibiting defective sweating responses

Hayakawa, Jun; Mizukawa, Yoshiko; Kurata, Maiko; Shiohara, Tetsuo

doi:10.1016/j.jaad.2012.11.039

Cited by 14 publications

(9 citation statements)

References 19 publications

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“…The body may also be affected by sarcoid lesions. 56 Sarcoidosis in childhood and youth presents in two age-dependent, distinct forms. When pressure is applied with a glass slide or a dermoscope, the erythematous coloration fades and the yellow-brown color (often described as resembling the hue of apple jelly) can be clearly appreciated.…”

Section: Cutaneous Manifestationsmentioning

confidence: 99%

“…55 Syringotropic sarcoidosis is a recently described variant of sarcoidosis characterized by erythematous patches or plaques predominantly affecting the extensor aspect of the lower limbs, with histologic evidence of sarcoidal granulomas mainly localized around sweat glands and exhibiting defective sweating responses. 56 Sarcoidosis in childhood and youth presents in two age-dependent, distinct forms. Early-onset sarcoidosis, which occurs in children aged under five years, involves the triad of exanthema, arthritis, and uveitis, along with recurrent fever and no apparent pulmonary involvement.…”

Section: Cutaneous Manifestationsmentioning

confidence: 99%

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Cutaneous sarcoidosis: an intriguing model of immune dysregulation

et al. 2014

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Sarcoidosis is a systemic granulomatous disease characterized by the presence of non-caseating granulomas. Its etiology remains obscure. A plausible hypothesis suggests that a complex interplay of host factors, infectious processes, and non-infectious environmental factors, matched with a susceptible genetic background, results in a pathway that leads to systemic granulomatous inflammation. Although presentations of sarcoidosis vary enormously, multi-organ involvement is a common feature. Cutaneous involvement occurs in about 25% of patients with protean manifestations and variable prognoses. Skin manifestations are divided into specific lesions with histopathologically evident non-caseating granulomas and nonspecific lesions arising from a reactive process that does not form granulomas. A peculiar form of cutaneous sarcoidosis is represented by sarcoidal lesions at sites of trauma that has caused scarring. The pathogenesis of scar sarcoidosis remains unknown. Scar sarcoidosis is also associated with herpes zoster infection, surgery, and tattooing. Such heterogeneous events, along with those at the sites of chronic lymphedema, thermal burns, radiation dermatitis, and vaccinations, occur on areas of vulnerable skin labeled "immunocompromised districts". Numerous options are available for the treatment of cutaneous sarcoidosis. Although corticosteroids remain the treatment of choice for initial systemic therapy, other nonsteroidal agents have proven effective and therefore useful for long-term management. Tumor necrosis factor-α antagonists such as infliximab may have a role in the treatment of cutaneous sarcoidosis, especially in refractory cases that are resistant to standard regimens. Elucidation of the relationship of sarcoidal granulomas with malignancy and immunity may facilitate a better understanding of some pathomechanisms operating in neoplastic and immunity-related disorders.

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Section: Cutaneous Manifestationsmentioning

confidence: 99%

Section: Cutaneous Manifestationsmentioning

confidence: 99%

Cutaneous sarcoidosis: an intriguing model of immune dysregulation

et al. 2014

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“…Verrucous sarcoidosis is an uncommon variant which may mimic squamous cell carcinoma clinically (Stockman et al 2013 ). Another rare variant is syringotropic sarcoidosis, which presents as multiple erythematous patches or plaques on the lower extremities (Hayakawa et al 2013 ). Interestingly, the sweating responses to thermal stress were reported to be markedly diminished in these cases.…”

Section: Clinical Featuresmentioning

confidence: 99%

“…Scar sarcoidosis refers to sarcoidosis involving a preexisting scar, including post-herpes zoster scars (Selim et al 2006 ). An interesting fi nding in the syringotropic variant was the profoundly decreased expression of dermcidin and aquaporin 5 in the affected sweat glands (Hayakawa et al 2013 ). In verrucous sarcoidosis, there is verrucous pseudoepitheliomatous hyperplasia of the overlying epidermis (Stockman et al 2013 ).…”

Section: Histopathologymentioning

confidence: 99%

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Cutaneous Hematopathology

2014

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The importance of considering skin diseases from a temporal perspective: Special emphasis on the effects of corticosteroids and virally induced diseases

Shiohara

Mizukawa

2018

J Cutaneous Imm & Allergy

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The efficacy and safety of medical therapies assessed on the basis of short-term outcomes are often considered to inform the long-term outcomes. Even in corticosteroid therapy, either systemic or topical, which is most frequently used as a first-line therapy to control inflammation, few studies have reported the risk/benefit ratio for Abbreviations: autoAb, autoantibody; DiHS/DRESS, drug-induced hypersensitivity syndrome/drug reaction with eosinophilia and systemic symptoms; HZ, herpes zoster; IMQ, imiquimod; IRIS, immune reconstitution inflammatory syndrome.---

show abstract

A syringotropic variant of cutaneous sarcoidosis: Presentation of 3 cases exhibiting defective sweating responses

Cited by 14 publications

References 19 publications

Cutaneous sarcoidosis: an intriguing model of immune dysregulation

Cutaneous sarcoidosis: an intriguing model of immune dysregulation

Cutaneous Hematopathology

The importance of considering skin diseases from a temporal perspective: Special emphasis on the effects of corticosteroids and virally induced diseases

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