A thermoelastohydrodynamic (TEHD) coupling model is developed to study the static performance of a heavy-duty tilting pad thrust bearing (TPTB) under the effect of axis misalignment. To ensure the validity in calculating thermoelastic deformation, the calculation accuracy of the mechanical and thermal deformations used in the TEHD model is verified by the finite element method (FEM). The influence of the TEHD model on the flow state prediction is determined using different axial loads, and the numerical analysis of turbulence model and centrifugal inertia term on the bearing pad temperature is conducted at various operating rotation speeds. Compared with the aligned bearing performance, the characteristic distribution of each bearing pad under different misaligned angles is obtained. The effect of misalignment will cause local overheating of the thrust-bearing pads, especially for the heavy-duty TPTD. The results of this study can help to improve the prediction accuracy of heavy-duty TPTB characteristics and avoid harmful misalignment effects. Therefore, it is necessary to consider the effects of misalignment, turbulence, and thermoelastic deformation in the design and analysis of thrust bearings.