This work presents the experimental evaluation of energy consumption and refrigerant charge reduction when a commercial direct expansion refrigeration system is converted into an indirect system. The evaluation (with R-134a and R-507A) used a commercial cabinet with doors for medium temperature and a single-stage refrigeration cycle using a semi-hermetic compressor and electronic expansion valve; 24-h energy consumption tests were performed at laboratory conditions for each refrigerant and configuration at three heat rejection levels (23.3, 32.8 and 43.6 • C), maintaining an average product temperature inside the cabinet of 2 • C. The work analyses the impact of the conversion on temperature and pressure indicators, as well as, in the energy performance of each element. For R-134a the refrigerant charge was reduced in a 42.9%, but the energy consumption rose by 22.0%-22.8%; for R-507A the charge reduction was of 32.8% with an increase in energy consumption of between 27.7% and 38.7%.