A systematic approach of chitosan nanoparticle preparation via emulsion crosslinking as potential adsorbent in wastewater treatment

Riegger, Benjamin R.; Bäurer, Bernd; Mirzayeva, Aziza; Tovar, Günter E. M.; Bach, Monika

doi:10.1016/j.carbpol.2017.10.002

Cited by 68 publications

(31 citation statements)

References 45 publications

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“…NPs have outstanding features such as prolonged systemic circulation, high preferential retention at tumor sites and the ability to overcome P-glycoprotein-mediated multidrug resistance of cancer cells [ 10 ]. There are many methods to prepare chitosan-based NPs, such as emulsion-cross-linking [ 11 ], emulsion-solvent evaporation coacervation [ 12 ], complex coacervation [ 13 ], spray drying [ 14 ], ionotropic gelation [ 15 , 16 , 17 ], membrane emulsification [ 18 ], covalent conjugation, [ 19 , 20 ], and dopamine polymerization [ 19 ].…”

Section: Introductionmentioning

confidence: 99%

Understanding the Factors Influencing Chitosan-Based Nanoparticles-Protein Corona Interaction and Drug Delivery Applications

et al. 2020

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Chitosan is a polymer that is extensively used to prepare nanoparticles (NPs) with tailored properties for applications in many fields of human activities. Among them, targeted drug delivery, especially when cancer therapy is the main interest, is a major application of chitosan-based NPs. Due to its positive charges, chitosan is used to produce the core of the NPs or to cover NPs made from other types of polymers, both strategies aiming to protect the carried drug until NPs reach the target sites and to facilitate the uptake and drug delivery into these cells. A major challenge in the design of these chitosan-based NPs is the formation of a protein corona (PC) upon contact with biological fluids. The composition of the PC can, to some extent, be modulated depending on the size, shape, electrical charge and hydrophobic / hydrophilic characteristics of the NPs. According to the composition of the biological fluids that have to be crossed during the journey of the drug-loaded NPs towards the target cells, the surface of these particles can be changed by covering their core with various types of polymers or with functionalized polymers carrying some special molecules, that will preferentially adsorb some proteins in their PC. The PC’s composition may change by continuous processes of adsorption and desorption, depending on the affinity of these proteins for the chemical structure of the surface of NPs. Beside these, in designing the targeted drug delivery NPs one can take into account their toxicity, initiation of an immune response, participation (enhancement or inhibition) in certain metabolic pathways or chemical processes like reactive oxygen species, type of endocytosis of target cells, and many others. There are cases in which these processes seem to require antagonistic properties of nanoparticles. Products that show good behavior in cell cultures may lead to poor in vivo results, when the composition of the formed PC is totally different. This paper reviews the physico-chemical properties, cellular uptake and drug delivery applications of chitosan-based nanoparticles, specifying the factors that contribute to the success of the targeted drug delivery. Furthermore, we highlight the role of the protein corona formed around the NP in its intercellular fate.

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Section: Introductionmentioning

confidence: 99%

Understanding the Factors Influencing Chitosan-Based Nanoparticles-Protein Corona Interaction and Drug Delivery Applications

et al. 2020

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“…Chemical modifications such as oligomerization, alkylation, acylation, quaternization, hydroxyalkylation, carboxyalkylation, thiolation, sulfation, phosphorylation, enzymatic modifications and graft copolymerization have been carried out, allowing obtaining modified properties for specific end used applications in a large variety of fields [1]. Following physical and chemical methods, researchers have managed to produce a variety of forms of chitosan such as gel beads, membranes, film, fibers, porous frameworks, powders, sponges, hollow fibres and nanoparticles [11][12][13][14][15][16][17][18][19][20]. Some chemical modifications have been found capable of enhancing its flexibility and chemical stability and lower its susceptibility to acidic media.…”

Section: Introductionmentioning

confidence: 99%

“…Chitin-Chitosan -Myriad Functionalities in Science and Technology the functional properties of chitosan while improving the mechanical strength, cross-linking might be found. Several reagents such as glyoxal, glutaraldehyde and epichlorohydrin have been employed to reinforce the structure of chitosan by cross-linking[19,[21][22][23].…”

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confidence: 99%

A Review of Chitosan-Based Materials for the Removal of Organic Pollution from Water and Bioaugmentation

Escudero-Oñate¹,

Martínez-Francés²

2018

Chitin-Chitosan - Myriad Functionalities in Science and Technology

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Chitin is a natural polymer extracted mostly from shrimp or crab shells and is the Earth's second most abundant polysaccharide. After a simple deacetylation procedure, chitin is converted into chitosan that consists in a polysaccharide structure of deacetylated-β-glucosamine. Chitosan has been largely employed in wastewater treatment the removal of colloids through coagulation-flocculation processes. Different chitosan based materials have been produced and tested in the removal of inorganic pollutants such as toxic metals and metalloids, nutrients, dyes, micropollutants and hydrocarbons. Sorbents such as magnetic-activated carbon chitosan have been successfully tested in the removal of antibiotics (ciprofloxacin, erythromycin and amoxicillin) from water. Raw chitosan and ZnO nanoparticles entrapped in chitosan have demonstrated an excellent potential for the removal of the insecticide permethrin from aqueous effluents. Chitin and chitosan in flake and powder form have also demonstrated a promising effectiveness in the removal of oil spilled in seawater. Superhydrophobic and superoleophilic sponges modified by thioles have been also prepared from chitosan and used for the removal of oil spills. Chitosan hydrogels have been tested as well as entrapment matrices for the immobilization of hydrocarbon-degrading biomass for oil spills. Strains such as R. corynebacteriorides (QBTo), Bacillus subtilis LAMI008 and B. pumilus have been successfully immobilized and employed in hydrocarbon degradation processes. In this book chapter, the use of chitosan and chitosan-based materials in the removal of organic pollutants from water is reviewed.

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“…Different approaches have been used to produce CS nanoparticles. These include ionotropic gelation [13,14], spray drying [15], water-in-oil emulsion cross-linking [16], reverse micelle formation [17,18], emulsion-droplet coalescence [19,20], nanoprecipitation [21] and by a self-assembling mechanism [22,23].…”

Section: Introductionmentioning

confidence: 99%

Chitosan Based Self-assembled Nanoparticles in Drug Delivery

Quiñones

Peniche

Péniche

2018

Preprint

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Chitosan is a cationic polysaccharide usually obtained by alkaline deacetylation of chitin poly(N-acetylglucosamine). It is biocompatible, biodegradable, mucoadhesive and non-toxic. These excellent biological properties make chitosan a good candidate for a platform in developing drug delivery systems having improved biodistribution, increased specificity and sensitivity, and reduced pharmacological toxicity. In particular, chitosan nanoparticles are found to be appropriate for non-invasive routes of drug administration: oral, nasal, pulmonary and ocular routes. These applications are facilitated by the absorption-enhancing effect of chitosan. Many procedures for obtaining chitosan nanoparticles have been proposed. Particularly, the introduction of hydrophobic moieties into chitosan molecules by grafting to generate a hydrophobic-hydrophilic balance promoting self-assembly is a current and appealing approach. The grafting agent can be a hydrophobic moiety forming micelles that can entrap lipophilic drugs or it can be the drug itself. Another suitable way to generate self-assembled chitosan nanoparticles is through the formation of polyelectrolyte complexes with polyanions. This paper reviews the main approaches for preparing chitosan nanoparticles by self-assembly through both procedures and illustrates the state of the art of their application in drug delivery.

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A systematic approach of chitosan nanoparticle preparation via emulsion crosslinking as potential adsorbent in wastewater treatment

Cited by 68 publications

References 45 publications

Understanding the Factors Influencing Chitosan-Based Nanoparticles-Protein Corona Interaction and Drug Delivery Applications

Understanding the Factors Influencing Chitosan-Based Nanoparticles-Protein Corona Interaction and Drug Delivery Applications

A Review of Chitosan-Based Materials for the Removal of Organic Pollution from Water and Bioaugmentation

Chitosan Based Self-assembled Nanoparticles in Drug Delivery

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