A systematic evaluation of the cucurbit[7]uril pharmacokinetics and toxicity after a single dose and short-term repeated administration in mice

Pejchal, Jaroslav; Jost, Philipp J.; Múčková, Lubica; Andrýs, Rudolf; Lísa, Miroslav; Karasová, Jana Žďárová

doi:10.1007/s00204-022-03249-7

Cited by 5 publications

(6 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Although toxicity studies [206][207][208] have been conducted for contrast agents from the cucurbit[n]uril family, specifically for CB7 and CB8, there is currently no available data regarding CB6 in this regard. Furthermore, there is no previous data on the blood half-life of CB6, making it challenging to calculate the dose at a given time after injection.…”

Section: In Vivo Hypercest Imagingmentioning

confidence: 99%

Hyperpolarized Xenon-129 Chemical Exchange Saturation Transfer (HyperCEST) Molecular Imaging: Achievements and Future Challenges

Batarchuk,

Shepelytskyi,

Grynko

et al. 2024

IJMS

View full text Add to dashboard Cite

Molecular magnetic resonance imaging (MRI) is an emerging field that is set to revolutionize our perspective of disease diagnosis, treatment efficacy monitoring, and precision medicine in full concordance with personalized medicine. A wide range of hyperpolarized (HP) 129Xe biosensors have been recently developed, demonstrating their potential applications in molecular settings, and achieving notable success within in vitro studies. The favorable nuclear magnetic resonance properties of 129Xe, coupled with its non-toxic nature, high solubility in biological tissues, and capacity to dissolve in blood and diffuse across membranes, highlight its superior role for applications in molecular MRI settings. The incorporation of reporters that combine signal enhancement from both hyperpolarized 129Xe and chemical exchange saturation transfer holds the potential to address the primary limitation of low sensitivity observed in conventional MRI. This review provides a summary of the various applications of HP 129Xe biosensors developed over the last decade, specifically highlighting their use in MRI. Moreover, this paper addresses the evolution of in vivo applications of HP 129Xe, discussing its potential transition into clinical settings.

show abstract

Section: In Vivo Hypercest Imagingmentioning

confidence: 99%

Hyperpolarized Xenon-129 Chemical Exchange Saturation Transfer (HyperCEST) Molecular Imaging: Achievements and Future Challenges

Batarchuk,

Shepelytskyi,

Grynko

et al. 2024

IJMS

View full text Add to dashboard Cite

show abstract

“…165,166 Very recently a systematic evaluation of the CB [7] pharmacokinetics and toxicity was performed to evaluate specific organ toxicity, i.e., on plasma, brain, kidney, and gastrointestinal tract by various methods of injection (intramuscular, intraperitoneal and intragastric). 174 Only minor liver damage was observed when CB [7] was administered intragastrically.…”

Section: Rsc Medicinal Chemistry Reviewmentioning

confidence: 99%

“…, on plasma, brain, kidney, and gastrointestinal tract by various methods of injection (intramuscular, intraperitoneal and intragastric). 174 Only minor liver damage was observed when CB[7] was administered intragastrically. Overall, parenteral administration led to fast elimination from blood and minimal absorption from the gastrointestinal tract and was well tolerated even when repeated.…”

Section: Cucurbit[ N ]Urils In Drug Deliverymentioning

confidence: 99%

“…Unfortunately, kidney damage was observed and 3.6% of animals showed signs of nephrotoxicity which may be the most critical drawback of its parenteral use, since most of its elimination from the body is through excretion by kidneys. 174 Nevertheless, toxicological profiles of CB[ n ]s in general, even acyclic-CB[ n ] and CB[ n ]-type 175 ones, support the idea of their exploitation in biological applications at subtoxic concentrations. Although CB[ n ]s seem to be promising molecules, long-term side effects from continuous use of CB[ n ]s are still relatively unknown and should be determined, which is also one of the reasons that CB[ n ]s are presently not in clinical use and have not yet been tested in humans.…”

Section: Cucurbit[ N ]Urils In Drug Deliverymentioning

confidence: 99%

See 1 more Smart Citation

Overcoming barriers with non-covalent interactions: supramolecular recognition of adamantyl cucurbit[n]uril assemblies for medical applications

Alešković,

Šekutor

2024

RSC Med. Chem.

View full text Add to dashboard Cite

show abstract

“…Thus, the assessment of the biological safety of cucurbiturils is relevant. It is now known that cucurbiturils have demonstrated low toxicity in a lot of in vitro and in vivo studies [ 21 , 22 , 23 , 24 , 25 , 26 ]. The use of cucurbiturils at very high doses may cause myotoxicity and neurotoxicity, but there are no signs of toxicity at standard concentrations used in complexation with drugs.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the Immunosafety of Cucurbit[n]uril In Vivo

Pashkina,

Aktanova,

Boeva

et al. 2024

Pharmaceutics

View full text Add to dashboard Cite

Cucurbiturils are a family of macrocyclic oligomers capable of forming host–guest complexes with various molecules. Due to noncovalent binding to drug molecules and low toxicity, cucurbiturils has been extensively investigated as potential carriers for drug delivery. However, the immune system’s interactions with different drug carriers, including cucurbiturils, are still under investigation. In this study, we focused on cucurbiturils’ immunosafety and immunomodulation properties in vivo. We measured blood counts and lymphocyte subpopulations in blood, spleen, and bone marrow, and assessed the in vivo toxicity to spleen and bone marrow cells after intraperitoneal administration to BALB/c mice. When assessing the effect of cucurbit[6]uril on blood parameters after three intraperitoneal injections within a week in laboratory animals, a decrease in white blood cells was found in mice after injections of cucurbit[6]util, but the observed decrease in the number of white blood cells was within the normal range. At the same time, cucurbit[7]uril and cucurbit[8]uril did not affect the leukocyte counts of mice after three injections. Changes in the number of platelets, erythrocytes, and monocytes, as well as in several other indicators, such as hematocrit or erythrocyte volumetric dispersion, were not detected. We show that cucurbiturils do not have immunotoxicity in vivo, with the exception of a cytotoxic effect on spleen cells after сucurbit[7]uril administration at a high dosage. We also evaluated the effect of cucurbiturils on cellular and humoral immune responses. We founded that cucurbiturils in high concentrations affect the immune system in vivo, and the action of various cucurbiturils differs in different homologues, which is apparently associated with different interactions in the internal environment of the body.

show abstract

A systematic evaluation of the cucurbit[7]uril pharmacokinetics and toxicity after a single dose and short-term repeated administration in mice

Cited by 5 publications

References 36 publications

Hyperpolarized Xenon-129 Chemical Exchange Saturation Transfer (HyperCEST) Molecular Imaging: Achievements and Future Challenges

Hyperpolarized Xenon-129 Chemical Exchange Saturation Transfer (HyperCEST) Molecular Imaging: Achievements and Future Challenges

Overcoming barriers with non-covalent interactions: supramolecular recognition of adamantyl cucurbit[n]uril assemblies for medical applications

Evaluation of the Immunosafety of Cucurbit[n]uril In Vivo

Contact Info

Product

Resources

About