A systematic examination of brain volumetric abnormalities in recent-onset schizophrenia using voxel-based, surface-based and region-of-interest-based morphometric analyses

John, John P.; Lukose, Ammu; Bagepally, Bhavani Shankara; Halahalli, Harsha N.; Moily, Nagaraj S.; Vijayakumari, Anupa A.; Jain, Sanjeev

doi:10.1186/s12952-015-0030-z

Cited by 10 publications

(4 citation statements)

References 63 publications

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“…Although most studies using VBM analysis have reported gray matter density reduction in patients in the early stages of schizophrenia, some researchers revealed no such results 45,46 . Our study corroborated the latter's finding and revealed no difference in gray matter density between the brain regions of patients diagnosed with schizophrenia for less than 5 years and those of the controls.…”

Section: Progression Of Brain Abnormalities Throughout the Illness Co...mentioning

confidence: 99%

Progressive brain abnormalities in schizophrenia across different illness periods: a structural and functional MRI study

et al. 2023

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Schizophrenia is a chronic brain disorder, and neuroimaging abnormalities have been reported in different stages of the illness for decades. However, when and how these brain abnormalities occur and evolve remains undetermined. We hypothesized structural and functional brain abnormalities progress throughout the illness course at different rates in schizophrenia. A total of 115 patients with schizophrenia were recruited and stratified into three groups of different illness periods: 5-year group (illness duration: ≤5 years), 15-year group (illness duration: 12–18 years), and 25-year group (illness duration: ≥25 years); 230 healthy controls were matched by age and sex to the three groups, respectively. All participants underwent resting-state MRI scanning. Each group of patients with schizophrenia was compared with the corresponding controls in terms of voxel-based morphometry (VBM), fractional anisotropy (FA), global functional connectivity density (gFCD), and sample entropy (SampEn) abnormalities. In the 5-year group we observed only SampEn abnormalities in the putamen. In the 15-year group, we observed VBM abnormalities in the insula and cingulate gyrus and gFCD abnormalities in the temporal cortex. In the 25-year group, we observed FA abnormalities in nearly all white matter tracts, and additional VBM and gFCD abnormalities in the frontal cortex and cerebellum. By using two structural and two functional MRI analysis methods, we demonstrated that individual functional abnormalities occur in limited brain areas initially, functional connectivity and gray matter density abnormalities ensue later in wider brain areas, and structural connectivity abnormalities involving almost all white matter tracts emerge in the third decade of the course in schizophrenia.

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Section: Progression Of Brain Abnormalities Throughout the Illness Co...mentioning

confidence: 99%

Progressive brain abnormalities in schizophrenia across different illness periods: a structural and functional MRI study

et al. 2023

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“…However, there is no consensus on the most accurate way of the brain/head-size adjustment in statistical analyses (Arndt et al, 1991;Mathalon et al, 1993;O'Brien et al, 2006). Since TBV and ICV have their advantages and disadvantages (John et al, 2015), we decided to compare the regional brain volumes using both measures. The interactions and associations were studied in the GLM (General Linear Model) ANCOVA environment with TBV, ICV, age, sex as the co-variates and the sex-age interaction.…”

Section: Introductionmentioning

confidence: 99%

Whole Brain and Cranial Size Adjustments in Volumetric Brain Analyses of Sex- and Age-Related Trends

et al. 2020

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Our goal was to determine the influence of sex, age and the head/brain size on the compartmental brain volumes in the radiologically verified healthy population (96 subjects; 54 women and 42 men) from the Upper Silesia region in Poland. The MRI examinations were done using 3T Philips Achieva with the same T1-weighted and T2-weighted protocols. The image segmentation procedures were performed with SPM (Statistical Parameter Mapping) and FSL-FIRST software. The volumes of 14 subcortical structures for the left and right hemispheres and 4 overall volumes were calculated. The General Linear Models (GLM) analysis was used with and without the Total Brain Volume (TBV) and Intracranial Volume (ICV) parameters as the covariates to study the regional vs. global brain atrophy. After the ICV/TBV adjustments, the majority of sex differences in the specific volumes of interest (VOIs) revealed to be linked to the difference in the head/brain size parameters. The analysis also confirmed the significant effect of the aging process on the brain loss. After the TBV adjustment, the age-and sex-related volumetric trends for the gray and white matter volumes were observed: the negative age dependence of the gray matter volume is more pronounced in the males, while in case of the white matter the positive age-related trend in the female group is weaker. The local losses of the left caudate nucleus and the right thalamus are more advanced than the global brain atrophy. Different head-size correction strategies are not interchangeable and may yield various volumetric results, but when used together, facilitate studies on the regional dependencies inherent to a healthy, but aging, brain.

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“…Beyond these primary aims, we also sought to compare results from voxel‐based morphometry (VBM) and surface‐based morphometry (SBM), two common structural imaging techniques for assessing GM. These approaches are rarely compared in morphometry studies [John et al, ; Smolker et al, ]; however, both methods provide estimates of volume, albeit by using different calculations [relative proportion of GM in VBM, versus surface area by cortical thickness in SBM; Smolker et al, ] that may provide complementary information about underlying pathology. While VBM is useful as an overall index, SBM might provide more useful information for further investigation of underlying mechanisms.…”

Section: Introductionmentioning

confidence: 99%

Negative and interactive effects of sex, aging, and alcohol abuse on gray matter morphometry

et al. 2016

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Chronic alcohol use is associated with declines in gray matter volume, as is the normal aging process. Less apparent, however, is how the interaction between aging and heavy alcohol use affects changes in gray matter across the lifespan. There is some evidence that women are more vulnerable to the negative effects of alcohol use on gray matter than men. In the current study, we examined whether localized gray matter was related to measures of alcohol use disorder (e.g., AUDIT score) in a large sample (N = 436) of participants, ages 18–55 years, with a range of disease severity, using both voxel-based morphometry (VBM) and surface-based morphometry (SBM). We also explored whether gray matter associations with alcohol use disorder (AUD) severity are moderated by sex and age. Results showed significant negative associations between AUD severity and gray matter volume throughout temporal, parietal, frontal, and occipital lobes. Women showed more negative effects of alcohol use than men for cortical thickness in left orbitofrontal cortex, but evidence for increased vulnerability based on sex was limited overall. Similarly, a specific age by alcohol use interaction was observed for volume of right insula, but other regional or global interactions were not statistically supported. However, significant negative associations between heavy alcohol use and gray matter volumes were observed as early as 18–25 years. These findings support that alcohol has deleterious effects on global and regional gray matter above and beyond age, and, of particular importance, that regional associations emerge in early adulthood.

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A systematic examination of brain volumetric abnormalities in recent-onset schizophrenia using voxel-based, surface-based and region-of-interest-based morphometric analyses

Cited by 10 publications

References 63 publications

Progressive brain abnormalities in schizophrenia across different illness periods: a structural and functional MRI study

Progressive brain abnormalities in schizophrenia across different illness periods: a structural and functional MRI study

Whole Brain and Cranial Size Adjustments in Volumetric Brain Analyses of Sex- and Age-Related Trends

Negative and interactive effects of sex, aging, and alcohol abuse on gray matter morphometry

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