2004
DOI: 10.1016/j.mod.2004.04.016
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A systematic genome-wide screen for mutations affecting organogenesis in Medaka, Oryzias latipes

Abstract: A large-scale mutagenesis screen was performed in Medaka to identify genes acting in diverse developmental processes. Mutations were identified in homozygous F3 progeny derived from ENU-treated founder males. In addition to the morphological inspection of live embryos, other approaches were used to detect abnormalities in organogenesis and in specific cellular processes, including germ cell migration, nerve tract formation, sensory organ differentiation and DNA repair. Among 2031 embryonic lethal mutations ide… Show more

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Cited by 127 publications
(85 citation statements)
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“…Medaka is thought to be a model organism complimentary to zebrafish because it is evolutionarily distant to zebrafish and has a different organization of the genome, which is more similar to Fugu (reviewed in Kimura et al, 2004). In addition to completion of the medaka draft genome (Kasahara et al, 2007), a large number of medaka mutants has been isolated from natural population or from ethylnitrosourea (ENU) -induced mutagenesis screening (Ishikawa, 2000;Loosli et al, 2000;Furutani-Seiki et al, 2004; H.T., unpublished data; many of them can be browsed at National BioResource Project Medaka in Japan at http:// shigen.lab.nig.ac.jp/medaka). As expected, some of those mutants exhibit unique phenotypes that have not been covered by zebrafish mutants.…”
Section: Medaka (The Japanese Killifish;mentioning
confidence: 99%
“…Medaka is thought to be a model organism complimentary to zebrafish because it is evolutionarily distant to zebrafish and has a different organization of the genome, which is more similar to Fugu (reviewed in Kimura et al, 2004). In addition to completion of the medaka draft genome (Kasahara et al, 2007), a large number of medaka mutants has been isolated from natural population or from ethylnitrosourea (ENU) -induced mutagenesis screening (Ishikawa, 2000;Loosli et al, 2000;Furutani-Seiki et al, 2004; H.T., unpublished data; many of them can be browsed at National BioResource Project Medaka in Japan at http:// shigen.lab.nig.ac.jp/medaka). As expected, some of those mutants exhibit unique phenotypes that have not been covered by zebrafish mutants.…”
Section: Medaka (The Japanese Killifish;mentioning
confidence: 99%
“…Medaka is a small egg-laying freshwater fish that allows both genetic and embryological analyses and is one of the three vertebrate model organisms in which genome-wide phenotype-driven mutant screens were carried out 1 . Divergence of functional overlap of related genes between medaka and zebrafish allows identification of novel phenotypes that are unidentifiable in a single species 2 , thus medaka and zebrafish are complementary for genetic dissection of the vertebrate genome functions.…”
Section: Introductionmentioning
confidence: 99%
“…Second, there are highly polymorphic inbred medaka strains available that can be used for mutagenesis screening and genetic mapping (Naruse et al 2004). These features significantly contribute to excellent forward genetics studies using medaka, such as the identification of the first sex-determining gene in non-mammalian vertebrates (Matsuda et al 2002(Matsuda et al , 2007, a large-scale mutagenesis screen to identify genes acting in diverse developmental processes (Furutani-Seiki et al 2004), and a fine quantitative trait locus analysis (Kimura et al 2007).…”
mentioning
confidence: 99%