A Systematic Literature Review of the Humanistic Burden of COPD

Hurst, John R.; Siddiqui, Mohd Kashif; Singh, Balwant; Varghese, Precil; Holmgren, Ulf; Nigris, Enrico De

doi:10.2147/copd.s296696

Cited by 39 publications

(24 citation statements)

References 58 publications

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“…At the early stage of the disease, patients are often asymptomatic or exhibit only mild chronic cough or dyspnea ( 21 , 22 ). However, as the disease progresses, patients may experience chest pain, expectoration, fatigue, weight loss, and can also develop acute lower respiratory infections, cardiovascular disease, or lung cancer that continue to place an enormous burden on society ( 23 , 24 ). According to the latest research, the prevalence of COPD in China is continually increasing, and the subgroup of patients over 40 years of age has nearly 99 million people, accounting for 13.7% ( 25 ).…”

Section: Discussionmentioning

confidence: 99%

A Preliminary Study on the Relationship Between High-Resolution Computed Tomography and Pulmonary Function in People at Risk of Developing Chronic Obstructive Pulmonary Disease

Xie

Jin

et al. 2022

Front. Med.

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ObjectivesPatients with chronic obstructive pulmonary disease (COPD) have high morbidity and mortality, the opportunity to carry out a thoracic high-resolution CT (HRCT) scan may increase the possibility to identify the group at risk of disease. The aim of our study was to explore the differences in HRCT emphysema parameters, air trapping parameters, and lung density parameters between high and low-risk patients of COPD and evaluate their correlation with pulmonary function parameters.MethodsIn this retrospective, single-center cohort study, we enrolled outpatients from the Physical Examination Center and Respiratory Medicine of The First Affiliated Hospital of Wenzhou Medical University. The patients who were ≥ 40 years-old, had chronic cough or sputum production, and/or had exposure to risk factors for the disease and had not reached the diagnostic criteria is considered people at risk of COPD. They were divided into low-risk group and high-risk group according to FEV1/FVC ≥ 80% and 80%>FEV1/FVC ≥ 70%. Data on clinical characteristics, clinical symptom score, pulmonary function, and HRCT were recorded.Results72 COPD high-risk patients and 86 COPD low-risk patients were enrolled in the study, and the air trapping index of left, right, and bilateral lungs of the high-risk group were higher than those of the low-risk group. However, the result of mean expiratory lung density was opposite. The emphysema index of left, right, and bilateral lungs were negatively correlated with FEV1/FVC (correlation coefficients were -0.33, -0.22, -0.26). Consistently, the air trapping index of left and right lungs and bilateral lungs were negatively correlated with FEV1/FVC (correlation coefficients were -0.33, -0.23, -0.28). Additionally, the mean expiratory lung density of left and right lungs and bilateral lungs were positively correlated with FEV1/FVC (correlation coefficients were 0.31, 0.25, 0.29).ConclusionThe emphysema index, air trapping index and the mean expiratory lung density shows significantly positive correlation with FEV1/FVC which can be used to assess the pulmonary function status of people at risk of COPD and provide a useful supplement for the early and comprehensive assessment of the disease.

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Section: Discussionmentioning

confidence: 99%

A Preliminary Study on the Relationship Between High-Resolution Computed Tomography and Pulmonary Function in People at Risk of Developing Chronic Obstructive Pulmonary Disease

Xie

Jin

et al. 2022

Front. Med.

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“…Chronic obstructive pulmonary disease (COPD) is the third leading cause of death and it is a global health problem with increasing prevalence. 1 COPD is characterized by coughing or wheezing, excess sputum production, and shortness of breath. 1 A subgroup of patients of COPD have progressive disease and results in the deterioration of cardiopulmonary function.…”

Section: Introductionmentioning

confidence: 99%

“… 1 COPD is characterized by coughing or wheezing, excess sputum production, and shortness of breath. 1 A subgroup of patients of COPD have progressive disease and results in the deterioration of cardiopulmonary function. 1 These patients tend to have poor exercise capacity and health-related quality of life (HRQL).…”

Section: Introductionmentioning

confidence: 99%

Different Responses to Pulmonary Rehabilitation in COPD Patients with Different Work Efficiencies

Jao¹,

Hsieh²,

Wu³

et al. 2022

COPD

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Background Chronic obstructive pulmonary disease (COPD) often involves the cardiopulmonary dysfunction that deteriorates health-related quality of life (HRQL) and exercise capacity. Work efficiency (WE) indicates the efficiency of overall oxygen consumption (VO 2 ) during exercise. This study investigated whether different WEs have different effects on pulmonary rehabilitation (PR). Methods Forty-five patients with stable COPD were scheduled for PR. The PR programs consisted of twice-weekly sessions for three months. These patients were comprehensively evaluated by cardiopulmonary exercise testing and COPD assessment test (CAT) before and after PR. We compared these parameters between patients with a normal versus poor WE. Results Twenty-one patients had a normal WE and twenty-four patients had a poor WE (<8.6 mL/min/watt). Patients with a poor WE had earlier anaerobic metabolism, a poorer oxygen pulse, lower exercise capacity, more exertional dyspnea, and a poorer HRQL than those with a normal WE. PR improved exercise capacity, HRQL, anaerobic threshold, exertional dyspnea and leg fatigue in patients with either normal or poor WE. However, significant improvement of WE, oxygen pulse, respiratory frequency (Rf) during exercise, chest tightness, activity and sleepiness by CAT were noted only in patients with a poor WE. Among the patients with a poor WE, 29% patients had WE returned to normal after PR. Conclusion Patients with different WE had different responses to PR. PR improved exercise capacity and HRQL regardless of a normal or poor WE. However, WE, oxygen pulse, Rf during exercise, chest tightness, activity and sleepiness were only improved in patients with a poor WE.

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“…Evidências crescentes oriundas de ensaios clínicos randomizados sugerem que os tratamentos farmacológicos podem causar benefícios significativos em uma série de desfechos, incluindo dispneia, qualidade de vida relacionada à saúde, frequência de exacerbações e mortalidade. (5)(6)(7) Neste número do Jornal Brasileiro de Pneumologia, Moreira et al (8) relataram uma associação entre a não adesão ao tratamento farmacológico e a mortalidade geral em pacientes com DPOC acompanhados em um programa público de gestão de doenças do sistema público de saúde brasileiro. Eles observaram, entre os pacientes com DPOC moderada a grave, uma taxa de adesão geral de 87,2%.…”

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“…Increasing evidence from randomized controlled trials suggests that pharmacological treatments may have meaningful benefits on a range of endpoints including dyspnea, health-related quality of life, frequency of exacerbations, and mortality. 5 - 7 …”

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confidence: 99%

Prescription is not enough: the importance of adherence to pharmacological treatment of COPD

Pereira

Matos

2022

J Bras Pneumol.

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A Systematic Literature Review of the Humanistic Burden of COPD

Cited by 39 publications

References 58 publications

A Preliminary Study on the Relationship Between High-Resolution Computed Tomography and Pulmonary Function in People at Risk of Developing Chronic Obstructive Pulmonary Disease

A Preliminary Study on the Relationship Between High-Resolution Computed Tomography and Pulmonary Function in People at Risk of Developing Chronic Obstructive Pulmonary Disease

Different Responses to Pulmonary Rehabilitation in COPD Patients with Different Work Efficiencies

Prescription is not enough: the importance of adherence to pharmacological treatment of COPD

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