A systematic review about Streptococcus Pneumoniae serotype distribution in children in mainland of China before the PCV13 was licensed

Abstract

Streptococcus pneumoniae (S. pneumoniae) is a major pathogen of infectious diseases in children. Surveillance of the distribution of pneumococcus serotypes is important for immunization strategies of pneumococcal polysaccharide conjugate vaccines (PCVs). Areas covered: This article is a systematic review of studies conducted from 2006 to 2016 that document serotypes of S. pneumoniae isolated from children less than 14 years old in the mainland of China. A total of 40 studies were included in this review. Serotypes 19F, 19A, 23F, 14 and 6B were the most common. Serotype prevalence and percentage varied by region and associated strains. The serotype coverage rate of PCV13 was higher than that of PCV10 due to the prevalence of serotype 19A, and there were no significant difference between the coverage rate of PCV13 and PPSV23. Expert commentary: To prevent Chinese children from S. pneumoniae infection, it is necessary for the universal immunization of PCV13 or develop new vaccines that include all the prevalent serotypes in China.

Serotype distribution ofStreptococcus pneumoniaeand potential impact of pneumococcal conjugate vaccines in China: A systematic review and meta-analysis

“…8 Thus, the most common serotypes causing IPD may vary slightly across geographic regions. Among the strains isolated from children aged younger than 18 years, serotypes 19F, 19A and 23F were the most common serotypes, results that were similar to those of Lyu et al 7 In addition, serotype 23F, 14 and 6B were important causes of either PD or IPD in children. This finding was consistent with the results from Western Europe and the USA that serogroups 14, 23, and 6 were common serogroups.…”

“…For all of the isolates included in our study, the coverage rates of PCV13 and PPSV23 were significantly higher than those of PCV10, with no significant differences between PCV13 and PPSV23, a finding that was s consistent with other study findings in China. 7,12 Although the number of serotypes in PPSV23 was more than that in PCV13, the serotype coverage of PPSV23 was slightly lower than that of PCV13, potentially due to the lack of serotype 6A in PPSV23 and the contribution of serotype 6A is higher than the combined contribution of the 11 serotypes unique to PPSV23. PCV13 has higher coverage compared with PCV7, 13 and the additional serotypes 1, 5, 7F, 3, 6A and 19A, especially for serotype 19A, account for a large proportion.…”

“…A recently published manuscript has reviewed the pneumococcal serotype distribution and coverage among Chinese children, but they did not include isolates from adults or provide detailed information regarding the serotype distribution and vaccine serotype coverage by age group. 7 Thus, to provide a comprehensive view of the pneumococcal isolate characteristics and estimate the potential impact of vaccines in China, we performed a systematic review and meta-analysis of publications on serotype distributions of pneumococcal infections in mainland China from 2000 to 2016.…”

GtfA Interacting with GtfB is Required for PsrP Glycosylation in Streptococcus pneumoniae

“…Because GtfA, GtfB, and PsrP are not present in about 50% of clinical iso-lates of S. pneumoniae, a PsrP-SecY2A2 island is not essential for S. pneumoniae growth. Nine serotypes were identified in 91 clinical isolates and the most frequent serotypes were 19F, 19A, 6A/B, and 23F, similar to the recently reported findings (12). The highest prevalence of PsrP was found in serotype 14, whereas no PsrP-positive isolate was found in serotypes 1 and 3 in the present study.…”

“…Mutations of GtfA, including N98A, E244A, E332A and S403A, block the glycosylation of PsrP (2,10). To date, 94 S. pneumoniae serotypes have been found (11)(12)(13)(14). Previous studies showed that PsrP was only detected in 51.7% of invasive S. pneumoniae isolates and in 48.3% of carrier S. pneumoniae isolates (15), thus, we sought to examine if the presence of the PsrP-SecY2A2 island is associated to a certain serotype of S. pneumoniae, or if GtfA and GtfB are conserved among these S. pneumoniae isolates and involved in the glycosylation of PsrP via the formation of the glycosyltransferase complex GtfA-GtfB.…”