A systematic review and economic evaluation of statins for the prevention of coronary events

Abstract

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Screening for glucose intolerance and development of a lifestyle education programme for prevention of type 2 diabetes in a population with intellectual disabilities: the STOP Diabetes research project

“…Instead, as with assigning first CVD events, the statin HTA reports the probability of future events, conditional on the nature of the previous event. 287 More details on the probabilities within a year of transitioning from stable angina, unstable angina, MI, TIA or stroke for individuals in different age groups can be found in an online discussion paper. 263 DOI: 10.3310/pgfar05110 PROGRAMME GRANTS FOR APPLIED RESEARCH 2017 VOL.…”

“…An absolute decrement of 0.004 per year is applied in the model; this is based on previous HTA modelling in CVD. 287 Body mass index and utility…”

“…Utility decrements for the variety of cardiovascular events were taken from a HTA assessing statins to reflect the utility decrements in the general population. 287 A burden-of-illness study with a broad utility decrement for cancer was identified and used to define utility decrements for breast and colon cancer. 304 A utility decrement for osteoarthritis was taken from a HTA, 305 and a utility decrement for depression was calculated from a trial that had used the EQ-5D.…”

Improving Adherence to Lipid-Lowering Therapy in a Community Pharmacy Intervention Program: A Cost-Effectiveness Analysis

“…43 The relationship between age and utility was described as follows: utility = 1.060-0.004 × age. 44 After a CVE, patients in the model incurred a disutility, based on data of the Dutch national burden of disease study. [45][46][47] After an MI or stroke, the disutility was 0.288 and 0.609, respectively.…”

Costs and health effects of adding functional foods containing phytosterols/-stanols to statin therapy in the prevention of cardiovascular disease

“…In cost-effectiveness analyses the costs and health effects of an intervention are compared to determine whether the intervention provides value-for-money (Morris et al, 2007). Statins have been assessed for cost-effectiveness in a range of publications (for review see Franco et al (2005) and Gumbs et al (2007)), and were found to be cost-effective for high risk patients (Franco et al, 2005;Ward et al, 2007). In contrast, to date only two studies evaluated the cost-effectiveness of phytosterols or -stanols (Gerber et al, 2006;Martikainen et al, 2007).…”