A systematic review and meta-analysis on the use of fibrin glue in peripheral nerve repair: Can we just glue it?

Koopman, Jaimy E.; Duraku, Liron S.; Jong, T. de; Vries, Rob B. M. de; Zuidam, J. Michiel; Hundepool, Caroline A.

doi:10.1016/j.bjps.2022.01.007

Cited by 34 publications

(27 citation statements)

References 79 publications

(129 reference statements)

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“…Most fibrin glues utilized in nerve surgery are dissolved in the human body by 2 weeks, which also accounts for the reported increased incidence of repair dehiscence. 7,10 Because the glue is theoretically completely dissolved before electrophysiologic testing is performed in animal survival studies (typically at 4 wk), this effect of conduction blockade would not be observed in the reported literature investigating fibrin glue and nerve repair. 9,11 Based on these findings, we cannot definitively conclude that PEG and fibrin glue are incompatible together.…”

Section: Discussionmentioning

confidence: 99%

“…The use of fibrin glue for nerve coaptation has been studied in animals since the 1940s with clinical trials starting in the 1970s. 7 There have been several studies comparing its efficacy in nerve coaptation against suture repair. 8,9 Many nerve surgeons utilize fibrin glue for its ease of use, reduced scarring to the nerve endings, and comparable outcome measures.…”

Section: Introductionmentioning

confidence: 99%

“…10,11 To our knowledge, no study has investigated the use of fibrin glue alongside PEG to treat nerve injuries. With growing support for fibrin glue nerve repairs in the literature [7][8][9][10][11] and increased interest in the use of PEG to study nerves immediately after injury, our team evaluated nerve function immediately following repairs with PEG and fibrin glue. We sought to determine if the two can be used together.…”

Section: Introductionmentioning

confidence: 99%

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Fibrin Glue Acutely Blocks Distal Muscle Contraction after Confirmed Polyethylene Glycol Nerve Fusion: An Animal Study

Fisher,

Johnsen,

Simon

et al. 2024

Plastic and Reconstructive Surgery - Global Open

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Background: Polyethylene glycol (PEG) is a synthetic, biodegradable, and hyperosmotic material promising in the treatment of acute peripheral nerve injuries. Our team set out to investigate the impact of fibrin glue upon PEG fusion in a rat model. Methods: Eighteen rats underwent sciatic nerve transection and PEG fusion. Electrophysiologic testing was performed to measure nerve function and distal muscle twitch. Fibrin glue was applied and testing repeated. Due to preliminary findings, fibrin glue was applied to an uncut nerve in five rodents and testing was conducted before and after glue application. Mann-Whitney U tests were used to compare median values between outcome measures. A Shapiro-Wilk test was used to determine normality of data for each comparison, significance set at a P value less than 0.05. Results: PEG fusion was confirmed in 13 nerves with no significant change in amplitude (P = 0.054), latency (P = 0.114), or conduction velocity (P = 0.114). Stimulation of nerves following PEG fusion produced distal muscle contraction in 100% of nerves. Following application of fibrin glue, there was a significant reduction in latency (P = 0.023), amplitude (P < 0.001), and conduction velocity (P = 0.023). Stimulation of the nerve after application of fibrin glue did not produce distal muscle twitch. Five uncut nerves with fibrin glue application blocked distal muscle contraction following stimulation. Conclusions: Our data suggest that fibrin glue alters the nerve’s function. The immediate confirmation of PEG fusion via distal muscle twitch is blocked with application fibrin glue in this experimental model. Survival and functional outcome studies are necessary to understand if this has implications on the long-term functional outcomes.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Fibrin Glue Acutely Blocks Distal Muscle Contraction after Confirmed Polyethylene Glycol Nerve Fusion: An Animal Study

Fisher,

Johnsen,

Simon

et al. 2024

Plastic and Reconstructive Surgery - Global Open

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“…To emulate the nerve microenvironment and permit 3D neurite outgrowth, we embedded the cell-seeded scaffold with fibrin, a natural material involved in nerve regeneration. Fibrin is cheap, does not necessitate functionalization, and has been widely used in the fabrication of PN models. − Furthermore, fibrin has also been successfully employed in the formation of in vitro vascular models, − thus being ideal for the fabrication of an NV platform. To replicate the nerve cellular milieu and achieve myelination, we co-cultured the neurons with rat SCs.…”

Section: Discussionmentioning

confidence: 99%

Development of an In Vitro Biomimetic Peripheral Neurovascular Platform

Malheiro

Seijas‐Gamardo

Harichandan

et al. 2022

ACS Appl. Mater. Interfaces

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Nerves and blood vessels are present in most organs and are indispensable for their function and homeostasis. Within these organs, neurovascular (NV) tissue forms congruent patterns and establishes vital interactions. Several human pathologies, including diabetes type II, produce NV disruptions with serious consequences that are complicated to study using animal models. Complex in vitro organ platforms, with neural and vascular supply, allow the investigation of such interactions, whether in a normal or pathological context, in an affordable, simple, and direct manner. To date, a few in vitro models contain NV tissue, and most strategies report models with nonbiomimetic representations of the native environment. To this end, we have established here an NV platform that contains mature vasculature and neural tissue, composed of human microvascular endothelial cells (HMVECs), induced pluripotent stem cell (iPSCs)-derived sensory neurons, and primary rat Schwann cells (SCs) within a fibrin-embedded polymeric scaffold. First, we show that SCs can induce the formation of and stabilize vascular networks to the same degree as the traditional and more thoroughly studied human dermal fibroblasts (HDFs). We also show that through SC prepatterning, we are able to control vessel orientation. Using our NV platform, we demonstrate the concomitant formation of three-dimensional neural and vascular tissue, and the influence of different medium formulations and cell types on the NV tissue outcome. Finally, we propose a protocol to form mature NV tissue, via the integration of independent neural and vascular constituents. The platform described here provides a versatile and advanced model for in vitro research of the NV axis.

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“…We prefer fibrin adhesive coaptation over suturing because it decreases operative time, mitigates neuroma formation, and provides similar functional outcomes as suturing. 6 7:35 Outcome. There was no intraoperative or postoperative complication.…”

Section: Transcriptmentioning

confidence: 99%

Transfer of extensor carpi radialis brevis branch of radial nerve to anterior interosseous nerve for lower trunk brachial plexopathy after motor vehicle accident

Westrup

Prather

Zhao

et al. 2023

Neurosurgical Focus: Video

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The patient is a 15-year-old male who sustained injury to his right lower brachial plexus (C8–T1) in a motor vehicle accident. Six months after the injury, the patient still had persistent hand weakness and wished to regain function in his first and second digits. Transfer of the extensor carpi radialis brevis (ECRB) branch of the radial nerve to the anterior interosseous nerve (AIN) was performed to restore motor function. The patient did well after the surgery, although it may take 12–24 months for benefits to fully manifest. Pertinent surgical anatomy and techniques are highlighted in this video demonstration. The video can be found here: https://stream.cadmore.media/rr10.3171/2022.10.FOCVID2287

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A systematic review and meta-analysis on the use of fibrin glue in peripheral nerve repair: Can we just glue it?

Abstract: A systematic review and meta-analysis on the use of fibrin glue in peripheral nerve repair: Can we just glue it?,

Cited by 34 publications

References 79 publications

Fibrin Glue Acutely Blocks Distal Muscle Contraction after Confirmed Polyethylene Glycol Nerve Fusion: An Animal Study

Fibrin Glue Acutely Blocks Distal Muscle Contraction after Confirmed Polyethylene Glycol Nerve Fusion: An Animal Study

Development of an In Vitro Biomimetic Peripheral Neurovascular Platform

Transfer of extensor carpi radialis brevis branch of radial nerve to anterior interosseous nerve for lower trunk brachial plexopathy after motor vehicle accident

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