A systematic review and meta-analysis on alcohol consumption and risk of endometriosis: an update from 2012

Abstract

Endometriosis is a complex and chronic disease, whose multifactorial nature has encouraged a deep investigation on the role of lifestyle factors. A strong association between alcohol intake and endometriosis risk has already been shown. We aimed to confirm this association, considering the updated literature. 23 eligible studies were identified through comprehensive literature search of PubMed and EMBASE (May 2012–October 2021). A borderline statistical significance was found comparing any alcohol consumption with no consumption (unadjusted OR 1.14; 95% CI: 0.99–1.31, p = 0.06), in contrast with a previous meta-analysis. However, we confirmed the significant association between moderate alcohol intake and endometriosis (unadjusted OR 1.22, 95% CI: 1.03–1.45, p = 0.02), also performing a sensitivity analysis (unadjusted OR 1.27, 95% CI: 1.04–1.54). Our partly divergent evidence reflects the tough challenge of isolating the impact of specific factors on the natural history of multifactorial diseases. Indeed, on one hand alcohol could be adopted by patients as a self-management therapy and on the other, it could favor the disease, promoting positive feedback with inflammatory mediators and oxidative stress. Our study encourages further investigation on the role of modifiable lifestyle factors and highlights the opportunity to adopt them to prevent or at least limit endometriosis progression.

Investigating Unhealthy Behaviors Associated with SF-36 Domains in Women with Endometriosis—Findings from a Web-Based Survey Data Set

“…This result is partly in contrast with the literature evidence. In fact, a recent meta-analytic study found a positive association between alcohol intake and endometriosis, suggesting that alcohol could be considered on one hand a coping strategy for the management of several difficulties related to endometriosis, and, on the other hand, it could directly increase the risk of developing endometriosis through inflammatory mediators and oxidative stress [ 62 ]. Hence, based on these contradictory findings, it is only possible to suppose that alcohol intake is an indicator of women’s general QoL.…”

Common Beverage Consumption and Benign Gynecological Conditions

“…amount of alcohol intake and endometriosis [84,95] Further, two meta-analyses performed by the same group looked at alcohol intake and endometriosis based on the literature available in 2012 and 2021 [96,97]. Their findings initially suggested an association between endometriosis and alcohol with a summary estimate OR of 1.24 (95% CI: 1.12, 1.36) [96].…”

“…However, several other case-control and cohort studies have concluded that there may not be a significant association [ 82 , 83 ]. Interestingly, one prospective cohort study of over 1700 individuals and a smaller observational study showed an inverse relationship between the amount of alcohol intake and endometriosis [ 84 , 95 ] Further, two meta-analyses performed by the same group looked at alcohol intake and endometriosis based on the literature available in 2012 and 2021 [ 96 , 97 ]. Their findings initially suggested an association between endometriosis and alcohol with a summary estimate OR of 1.24 (95% CI: 1.12, 1.36) [ 96 ].…”

Infertilidad asociada a endometriosis. Revisión bibliográfica

“…Asociaciones alimentarias: el mayor consumo de carne roja se asoció con un aumento del riesgo de https://doi.org/10.55204/scc.v2i2.e24 endometriosis (RR 1.17), al igual un mayor consumo de ácidos grasos trans (RR 1.12) y un mayor consumo de ácidos grasos saturados (RR 1.06) (46). Estilo de vida: el consumo de alcohol en general comparado con no consumo mostró una significancia estadística (RR 1.25 y OR 1.14) (47,48) y el consumo moderado de alcohol se relación de igual manera con riesgo de endometriosis (OR 1.22) (48). En la exposición a alteradores endocrinos: de manera general ofrecen un 41% mayor riesgo de endometriosis (RR: 1.41) (47), además, se identificó que los bifenilos policlorados (PCBs) tuvieron un aumento consistente en el riesgo (OR 1.58), seguido de los plaguicidas organoclorados (OCPs) (OR 1.40), esteres de Ftalato (PAEs) (OR 1.27), en el subgrupo de di-(2-etilhexil)-ftalato (DEHP) (OR 1.42) (tabla 1) (49) Carnes y Ácidos Grasos: Mayor consumo de carne roja se asoció con un aumento del riesgo de endometriosis (RR 1.17; 95% IC, 1.08 a 1.26; p < 0.001; I2 = 82.4%).…”

“…Las tasas de embarazo clínico (OR = 0.83; IC 95% = 0.66 a 1.05, p = 0.86), el número de óvulos maduros recuperados y las tasas de aborto no fueron estadísticamente diferentes entre los grupos de estudio. Sin embargo, el número total de óvulos recuperados fue menor en el grupo de cirugía (diferencia media = -1.51; IC del 95% = -2.60 a -0.43, p = 0.02) Abreviaturas: DIE: endometriosis infiltrante profunda, FIV: la fecundación in vitro, hMG: gonadotrofina humana, GnRH: hormona liberadora de gonadotrofina, HOC: hiperestimulación ovárica controlada, FIV/ICSI-ET: fecundación in vitro/inyección intracitoplasmática de espermatozoides-transferencia de embriones, MTC: medicina tradicional china, OR: Odds ratio, IC: intervalo de confianza Realizado por: María Guaman En la revisión exhaustiva de estudios observacionales y metaanálisis de Zhang et al (47) y Li et al (48), se evaluaron alrededor de 40 factores de riesgo ambientales en relación con la endometriosis. Estos factores incluyeron elementos relacionados con el estilo de vida, factores reproductivos, exposiciones tempranas en la vida, raza/etnia, y otros.…”