A systematic review and meta-analysis of the omega-3 fatty acids effects on brain-derived neurotrophic factor (BDNF)

Ziaei, Somayeh; Mohammadi, Shooka; Hasani, Motahareh; Morvaridi, Mehrnaz; Belančić, Andrej; Daneshzad, Elnaz; Saleh, Saleh A. K.; Adly, Heba M.; Heshmati, Javad

doi:10.1080/1028415x.2023.2245996

Nutritional Neuroscience

2023

DOI: 10.1080/1028415x.2023.2245996

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A systematic review and meta-analysis of the omega-3 fatty acids effects on brain-derived neurotrophic factor (BDNF)

Somayeh Ziaei,

Shooka Mohammadi,

Motahareh Hasani

et al.

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Cited by 4 publications

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Fish consumption, cognitive impairment and dementia: an updated dose-response meta-analysis of observational studies

Godos,

Micek,

Currenti

et al. 2024

Aging Clin Exp Res

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Background Cognitive impairment is projected to affect a preponderant proportion of the aging population. Lifelong dietary habits have been hypothesized to play a role in preventing cognitive decline. Among the most studied dietary components, fish consumptionhas been extensively studied for its potential effects on the human brain. Aims To perform a meta-analysis of observational studies exploring the association between fish intake and cognitive impairment/decline and all types of dementia. Methods A systematic search of electronic databases was performed to identify observational studies providing quantitative data on fish consumption and outcomes of interest. Random effects models for meta-analyses using only extreme exposure categories, subgroup analyses, and dose-response analyses were performed to estimate cumulative risk ratios (RRs) and 95% confidence intervals (CIs). Results The meta-analysis comprised 35 studies. Individuals reporting the highest vs. the lowest fish consumption were associated with a lower likelihood of cognitive impairment/decline (RR = 0.82, 95% CI: 0.75, 0.90, I2 = 61.1%), dementia (RR = 0.82, 95% CI: 0.73, 0.93, I2 = 38.7%), and Alzheimer’s disease (RR = 0.80, 95% CI: 0.67, 0.96, I2 = 20.3%). The dose-response relation revealed a significantly decreased risk of cognitive impairment/decline and all cognitive outcomes across higher levels of fish intake up to 30% for 150 g/d (RR = 0.70, 95% CI: 0.52, 0.95). The results of this relation based on APOE ε4 allele status was mixed based on the outcome investigated. Conclusions Current findings suggest fish consumption is associated with a lower risk of cognitive impairment/decline in a dose-response manner, while for dementia and Alzheimer’s disease there is a need for further studies to improve the strength of evidence.

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Fish consumption, cognitive impairment and dementia: an updated dose-response meta-analysis of observational studies

Godos,

Micek,

Currenti

et al. 2024

Aging Clin Exp Res

View full text Add to dashboard Cite

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The N-3 polyunsaturated fatty acids supplementation to prevent depression recurrence in patients with late-life depression: A 52-week double-blind, placebo-controlled trial

Cheng,

Chen,

Lin

et al. 2025

Journal of Affective Disorders

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Supplemental n-3 polyunsaturated fatty acids: Clinical implications and best practices for adult patients with cancer

Yang,

Wang,

Zhang

et al. 2024

J Nutr Oncol

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Background The purpose of this report is to summarize the evidence supporting supplementation of n-3 polyunsaturated fatty acids (n-3 PUFAs) in adult cancer patients, and to offer a better understanding of the appropriate use of n-3 PUFAs in the clinical setting. Methods Numerous databases were searched for guidelines, clinical decision-making documents, systematic reviews, expert consensus statements, and best evidence summaries about the use of n-3 PUFAs in cancer patients from the inception of the database to December 31, 2023. Evidence grading and recommendation rating were conducted. The data extracted included the timing of supplementation, symptom management, disease prevention, cost-effectiveness, route of administration, application scenarios, dosage, and safety. Results The collected data show that n-3 PUFAs are safe for patients receiving chemotherapy who are at risk of malnutrition and cachexia. Moreover, n-3 PUFA supplementation can alleviate the adverse symptoms associated with chemotherapy, extend survival, and improve the quality of life of patients with cancer. Conclusions The administration of supplementary n-3 PUFAs should be considered based on the patient’s disease stage, treatment plan, nutritional status, and tolerance, as well as the dosage, route and application scenarios. Promoting the clinical use of n-3 PUFAs may improve the outcomes for patients with cancer.

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A systematic review and meta-analysis of the omega-3 fatty acids effects on brain-derived neurotrophic factor (BDNF)

Cited by 4 publications

References 45 publications

Fish consumption, cognitive impairment and dementia: an updated dose-response meta-analysis of observational studies

Fish consumption, cognitive impairment and dementia: an updated dose-response meta-analysis of observational studies

The N-3 polyunsaturated fatty acids supplementation to prevent depression recurrence in patients with late-life depression: A 52-week double-blind, placebo-controlled trial

Supplemental n-3 polyunsaturated fatty acids: Clinical implications and best practices for adult patients with cancer

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