A systematic review and meta-analysis on the prevalence of Escherichia coli and extended-spectrum β-lactamase-producing Escherichia coli in pregnant women

Moradi, Yousef; Eshrati, Babak; Motevalian, Seyed Abbas; Majidpour, Ali; Baradaran, Hamid Reza

doi:10.1007/s00404-020-05903-w

Cited by 7 publications

(4 citation statements)

References 75 publications

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“…An increasing trend of multidrug-resistance, mainly due to ESBL production, was observed in E. coli isolated from pregnant woman with limited therapeutic options [ 50 ]. Earlier studies carried out in the 1990s found plasmid-mediated, transferable SHV-5 beta-lactamase conferring high level ceftazidime resistance among urinary E. coli isolates from the United Kingdom, and the isolates possessed additional TEM-1 β-lactamase [ 51 ].…”

Section: Escherichia Colimentioning

confidence: 99%

Mechanisms of Resistance in Gram-Negative Urinary Pathogens: From Country-Specific Molecular Insights to Global Clinical Relevance

Bedenić

Meštrović

2021

Diagnostics

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Urinary tract infections (UTIs) are the most frequent hospital infections and among the most commonly observed community acquired infections. Alongside their clinical importance, they are notorious because the pathogens that cause them are prone to acquiring various resistance determinants, including extended-spectrum beta-lactamases (ESBL); plasmid-encoded AmpC β-lactamases (p-AmpC); carbapenemases belonging to class A, B, and D; qnr genes encoding reduced susceptibility to fluoroquinolones; as well as genes encoding enzymes that hydrolyse aminoglycosides. In Escherichia coli and Klebsiella pneumoniae, the dominant resistance mechanisms are ESBLs belonging to the CTX-M, TEM, and SHV families; p-AmpC; and (more recently) carbapenemases belonging to classes A, B, and D. Urinary Pseudomonas aeruginosa isolates harbour metallo-beta-lactamases (MBLs) and ESBLs belonging to PER and GES families, while carbapenemases of class D are found in urinary Acinetobacter baumannii isolates. The identification of resistance mechanisms in routine diagnostic practice is primarily based on phenotypic tests for the detection of beta-lactamases, such as the double-disk synergy test or Hodge test, while polymerase chain reaction (PCR) for the detection of resistance genes is mostly pursued in reference laboratories for research purposes. As the emergence of drug-resistant bacterial strains poses serious challenges in the management of UTIs, this review aimed to appraise mechanisms of resistance in relevant Gram-negative urinary pathogens, to provide a detailed map of resistance determinants in Croatia and the world, and to discuss the implications of these resistance traits on diagnostic approaches. We summarized a sundry of different resistance mechanisms among urinary isolates and showed how their prevalence highly depends on the local epidemiological context, highlighting the need for tailored interventions in the field of antimicrobial stewardship.

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Section: Escherichia Colimentioning

confidence: 99%

Mechanisms of Resistance in Gram-Negative Urinary Pathogens: From Country-Specific Molecular Insights to Global Clinical Relevance

Bedenić

Meštrović

2021

Diagnostics

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“…The study's results indicate a high prevalence of E. coli and extendedspectrum-lactamase-producing (ESBL) E. coli in pregnant women, which aligns with our own findings. Furthermore, it was observed that the misuse of antibiotics was more prevalent among pregnant females in Europe and Asia as compared to other continents [22].…”

Section: Discussionmentioning

confidence: 99%

Effects of Plant Extracts on Bacterial Isolates from Infections of the Female Genital Tract

Naji¹,

Qaddoori

2023

PPASB

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Fifty samples of female genital secretions were collected from a group of women whose age ranges from 15 to 50 years old at Al-Batool Hospital for Maternity and Children. The isolates Escherichia coli, Staphylococcus aureus, Candida albicans, and Staphylococcus epidermidis were found in the fungal and bacterial cultures of the samples, with percentages of (45, 31, 13, 11), respectively. Positive samples were isolated at the highest rate of 87 percent for samples isolated from people aged 30 to 40. In the case of pregnancy, there is an increase in the infection rate with fungal and bacterial species, with a percentage of 60 % compared to women. The results of testing the effect of plant extracts (marjoram, chamomile, thyme, peat, and thuja) on isolated bacterial and fungal species showed inhibition diameters (20, 16, 15.5, 13, 10, 10) mm at concentrations (25 %, 50 %, 75 %, 100 %). We discovered that different concentrations of Marjoram, chamomile, thyme, peat, and thuja extracts (25 %, 50 %, 75 %, 100 %) were associated with increased inhibition rates of fungal and bacterial infection with different diameters (10, 12, 15, 16, 20 mm).

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“…Antimicrobial-resistant organisms, specifically extended spectrum β-lactamase (ESBL) producing E coli and methicillin-resistant Staphylococci aureus , are increasing in prevalence and limit antimicrobial treatment options. A recent meta-analysis found a prevalence of ESBL in pregnant people of 34% (95% CI 24–43%) (55). Additional studies demonstrated ESBL in approximately 50% of E coli and 37% of Klebsiella isolates, and methicillin-resistant S aureus was identified in almost 30% of S aureus isolates (56).…”

Section: Pyelonephritismentioning

confidence: 99%

Urinary Tract Infections in Pregnant Individuals

2023

Obstetrics &Amp; Gynecology

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SUMMARY Urinary tract infection (UTI) is one of the more common perinatal complications, affecting approximately 8% of pregnancies (1, 2). These infections represent a spectrum, from asymptomatic bacteriuria, to symptomatic acute cystitis, to the most serious, pyelonephritis. The presence of UTIs has been associated with adverse pregnancy outcomes, including increased rates of preterm delivery and low birth weight. Screening for and treating asymptomatic bacteriuria have been shown in multiple studies to reduce the incidence of pyelonephritis in pregnancy (3–5). Given the frequency at which UTIs are encountered in pregnancy, the ability to recognize, diagnose, and treat them is essential for those providing care to pregnant individuals. This Clinical Consensus document was developed using an established protocol in conjunction with the authors listed.

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A systematic review and meta-analysis on the prevalence of Escherichia coli and extended-spectrum β-lactamase-producing Escherichia coli in pregnant women

Cited by 7 publications

References 75 publications

Mechanisms of Resistance in Gram-Negative Urinary Pathogens: From Country-Specific Molecular Insights to Global Clinical Relevance

Mechanisms of Resistance in Gram-Negative Urinary Pathogens: From Country-Specific Molecular Insights to Global Clinical Relevance

Effects of Plant Extracts on Bacterial Isolates from Infections of the Female Genital Tract

Urinary Tract Infections in Pregnant Individuals

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