A Systematic Review and Meta-Analysis on the Effects of Exercise on the Endocannabinoid System

Desai, Shreya; Borg, Breanna; Cuttler, Carrie; Crombie, Kevin M.; Rabinak, Christine A.; Hill, Matthew N.; Marusak, Hilary A.

doi:10.1089/can.2021.0113

Cited by 30 publications

(17 citation statements)

References 102 publications

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“… 13 , 14 , 15 , 16 , 17 The increase in circulating oxylipins is generally more minor after low-exercise intensity or very short exercise than more intense or prolonged exercise bouts. 13 , 14 , 15 , 16 , 17 Circulating levels of AEA 18 , 19 , 20 , 21 , 22 , 23 and of the eCBs analogues PEA and OEA 24 also increase in response to acute endurance exercise in humans.…”

Section: Introductionmentioning

confidence: 99%

“…The long-term effect of exercise training on these lipid mediators is poorly understood. 3 , 13 , 23 So far, two independent studies have shown that long-term (14 and 145 days) endurance exercise decreases urinary oxylipins such as isoprostanes and plasma prostaglandins in humans. 25 , 26 On the other hand, we found no evidence of 12 weeks of different training modalities on the plasma levels of oxylipins, eCBs, and their analogues in middle-aged adults.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Acute and long-term exercise differently modulate plasma levels of oxylipins, endocannabinoids, and their analogues in young sedentary adults: A sub-study and secondary analyses from the ACTIBATE randomized controlled-trial

Jurado‐Fasoli

Sánchez-Delgado

et al. 2022

eBioMedicine

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Acute and long-term exercise differently modulate plasma levels of oxylipins, endocannabinoids, and their analogues in young sedentary adults: A sub-study and secondary analyses from the ACTIBATE randomized controlled-trial

Jurado‐Fasoli

Sánchez-Delgado

et al. 2022

eBioMedicine

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“…Third, a meta-analysis showed that effects of chronic exercise on the endocannabinoid system were inconsistent. The substantial heterogeneity might depend on the exercise intensity, physical fitness, timing of measurement, and/or fasted state [ 51 ]. Thus, the role of ECS in the occurrence and development of alcohol-induced brain disorders is complex.…”

Section: Discussionmentioning

confidence: 99%

Treadmill Exercise Prevents Cognitive Impairments in Adolescent Intermittent Ethanol Rats by Reducing the Excessive Activation of Microglia Cell in the Hippocampus

Guo

Yan

et al. 2022

IJMS

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The excessive activation of microglia cell induced by adolescent intermittent ethanol (AIE) leads to neuroinflammation in the hippocampus. The endocannabinoid system plays a key role in the modulation of microglia activation. Accumulating evidence suggests that regular exercise improves learning and memory deficits in AIE models. The purpose of this study was to explore the effects of treadmill exercise intervention on the cognitive performance, activation of microglia cells and the expression of monoacylglycerol lipase (MAGL), cannabinoid receptor type 1 (CB1R) and cannabinoid receptor type 2 (CB2R) in the hippocampus of AIE rats. Here, we show that AIE rats exhibited cognitive impairments, whereas the treadmill exercise improves the cognitive performance in AIE rats. In order to explore the possible mechanisms for the exercise-induced attenuation of cognitive disorder, we examined the neuroinflammation in the hippocampus. We found that treadmill exercise led to the decrease in the level of proinflammatory cytokines (IL-1β, IL-6 and TNF-α) and the increase in the level of anti-inflammatory cytokine (IL-10). In addition, we found that treadmill exercise reduced the excessive activation of the microglia cell in the hippocampus of AIE rats. Finally, we found that AIE led to a decrease in the expression of CB1R and CB2R in the hippocampus; however, the treadmill exercise further decreased the expression of CB2R in the hippocampus of AIE rats. Our results suggest that treadmill exercise attenuates AIE-induced neuroinflammation and the excessive activation of hippocampus microglial cells, which may contribute to the exercise-induced improvement of cognitive performance in AIE rats.

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“…Neben der Inhibition der Abbauenzyme stellt die Modulation des ECS über sportliche Aktivität eine potenziell therapieverbessernde Option dar. Wie eine Metaanalyse zeigen konnte, wird vor allem die AEA-Konzentration durch sportliche Aktivität erhöht [107]. Sowohl die therapiebedingten Veränderungen der Endocannabinoidkonzentrationen, z.…”

Section: Therapeutische Ansätzeunclassified

Multimodaler Ansatz zum Verständnis des Zusammenspiels zwischen dem endokrinen und dem Endocannabinoidsystem, nicht suizidalem selbstverletzendem Verhalten und der Borderline-Persönlichkeitsstörung

Spohrs¹,

Kuehnle²,

Ferger³

et al. 2023

Nervenheilkunde

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ZUSAMMENFASSUNGDie Borderline-Persönlichkeitsstörung (BPS) und, unabhängig davon, nicht suizidales selbstverletzendes Verhalten (NSSV) sind äußerst prävalente psychiatrische Störungsbilder, welche häufig mit weiteren psychischen Komorbiditäten einhergehen. Dennoch gibt es wenige wissenschaftliche Untersuchungen zu den zugrunde liegenden Mechanismen, die zudem der Verbesserung derzeitiger Behandlungsmöglichkeiten dienen können. Da Cannabiskonsum häufig zur Selbstmedikation bei Patienten mit BPS und NSSV eingesetzt wird und Cannabismissbrauch vermehrt vorkommt, liegt die Untersuchung des Endocannabinoidsystems (ECS) als potenziellen Modulator der Psychopathologie nahe. Des Weiteren sind die Stressverarbeitung als zugrunde liegender Faktor und die Funktionsfähigkeit des endokrinologischen Systems, welches eine zentrale Rolle in der Entwicklung und Aufrechterhaltung der BPS und NSSV spielt, eng mit dem ECS verbunden, welches unter anderem für die Modulation der Hypothalamus-Hypophysen-Nebennierenrinden (HPA)-Achse bekannt ist. Auch wenn mehr Forschung nötig ist, hat das ECS großes Potenzial die Behandlungsmöglichkeiten zu erweitern.

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A Systematic Review and Meta-Analysis on the Effects of Exercise on the Endocannabinoid System

Cited by 30 publications

References 102 publications

Acute and long-term exercise differently modulate plasma levels of oxylipins, endocannabinoids, and their analogues in young sedentary adults: A sub-study and secondary analyses from the ACTIBATE randomized controlled-trial

Acute and long-term exercise differently modulate plasma levels of oxylipins, endocannabinoids, and their analogues in young sedentary adults: A sub-study and secondary analyses from the ACTIBATE randomized controlled-trial

Treadmill Exercise Prevents Cognitive Impairments in Adolescent Intermittent Ethanol Rats by Reducing the Excessive Activation of Microglia Cell in the Hippocampus

Multimodaler Ansatz zum Verständnis des Zusammenspiels zwischen dem endokrinen und dem Endocannabinoidsystem, nicht suizidalem selbstverletzendem Verhalten und der Borderline-Persönlichkeitsstörung

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