A Systematic Review and Meta-Analysis on the Prevalence of Dementia in Europe: Estimates from the Highest-Quality Studies Adopting the DSM IV Diagnostic Criteria

Abstract

Background:Dementia, including Alzheimer’s disease (AD), is one of the most burdensome medical conditions. Usually, the reviews that aim at calculating the prevalence of dementia include estimates from studies without assessing their methodological quality. Alzheimer’s Disease International (ADI) proposed a score to assess the methodological quality of population-based studies aimed at estimating the prevalence of dementia. During the last three years, the European Commission has funded three projects (Eurodem, EuroCoDe, and ALCOVE) in order to estimate the prevalence of dementia in Europe.Objective:The aim of this study was to perform a systematic review and meta-analysis of data on the prevalence of dementia in Europe derived from studies that included only subjects with a diagnosis of dementia according to the DSM IV criteria, and that had a high quality score according to ADI criteria.Methods:We considered the studies selected by the two projects EuroCoDe (1993–2007) and Alcove (2008–2011), and we performed a new bibliographic search. For the systematic review, we only selected the subset of articles that included subjects with a diagnosis of dementia according to the DSM IV criteria. The studies were qualitatively assessed using the ADI tool.Results:The meta-analysis considered 9 studies that were carried out in Europe between 1993 and 2018 including a total of 18,263 participants, of which 2,137 were diagnosed with dementia. The prevalence rate standardized for age and sex resulted 7.1%.Discussion:This is the first systematic review on the prevalence of dementia in Europe considering only high-quality studies adopting the same diagnostic criteria (i.e., DSM IV).

The psychological and mental impact of coronavirus disease 2019 (COVID-19) on medical staff and general public – A systematic review and meta-analysis

“…The overall prevalence and 95% confidence interval of the psychological distress was pooled with random effects models using the Metaprop module in STATA (Bacigalupo et al, 2018;Nyaga et al, 2014). The heterogeneity between studies was assessed by the Cochran χ 2 and I 2 statistics (Higgins et al, 2003).…”

Когнитивные Нарушения И Деменция У Больных Артериальной Гипертензией. Часть І. Классификация, Распространенность, Механизмы Развития Нарушений Когнитивных Функций И Рекомендации По Обследованию Пациентов

“…У цілому втрата когнітивних функцій при деменції веде до практично повної або часткової десоціалізації пацієнта, що супроводжується загальним ослабленням організму, сприяє підвищенню частоти травматизації, до чого, як правило, приєднуються тяжкі коморбідні стани (повторні інсульти, запальні процеси, пневмонія, сепсис тощо), які врешті-решт ведуть до смерті хворих. [19,36,37].…”

Estimating dementia cases amongst migrants living in Europe

“…The estimated cases of dementia amongst older migrants living in Europe, and in each of the 32 countries considered, were calculated by multiplying the number of migrants with the age-and sex-specific prevalence rates. For each of the considered countries, Age-and sex-specific prevalence rates were taken from reference [17]; b Source: Eurostat (http://ec.europa.eu/eurostat/web/population-demogra phy-migration-projections/population-data/database); data are updated to 2017 except for Germany (2010); c No data were available for Germany concerning these specific age classes. EDC, estimated dementia cases; Migr., migrants.…”