A systematic review and meta‐analysis of neuropathic pain associated with coronavirus disease 2019

Stefano, Giulia Di; Falco, Pietro; Galosi, Eleonora; Pietro, Giuseppe Di; Leone, C.; Truini, Andrea

doi:10.1002/ejp.2055

Cited by 12 publications

(6 citation statements)

References 74 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Contrastingly, very few data are available for neuropathic pain. A recently published metanalysis has estimated it to occur in 10% (95% CI 5%–15%) of patients during acute/subacute COVID‐19 (di Stefano et al, 2023), but few studies have assessed its frequency and characteristics in the long run. Chronic neuropathic pain has been reported to occur in 24.6% of new‐COVID‐P patients (Herrero‐Montes et al, 2022).…”

Section: Discussionmentioning

confidence: 99%

Pain paths among post‐COVID‐19 condition subjects: A prospective cross‐sectional study with in‐person evaluation

Kubota

Soares

Fonseca

et al. 2023

European Journal of Pain

View full text Add to dashboard Cite

Background: New-onset chronic pain has been acknowledged as part of the post-COVID-19 condition. However, available fine-grained data about its clinical phenotype, trajectories and main associated characteristics remain scarce. We described the distinct temporal evolutions of post-COVID-19 pain and their epidemiological and phenotypical features. Methods: A prospective cross-sectional study enrolled post-COVID-19 condition patients (i.e. who had persisting COVID-19-related symptoms over 30 days since their first positive laboratory test), whose COVID-19 diagnosis had been supported by RT-PCR of oral/nasopharyngeal swab or serology. They underwent in-person evaluations with a structured interview, pain and quality-of-life-related questionnaires and thorough physical examination. Chronic pain (CP) and probable neuropathic pain (NP) were defined according to IASP criteria. Results:The present study included 226 individuals, 177 (78.3%) of whom presented over 3 months since their first COVID-19 symptom. New-onset pain occurred in 170 (75.2%) participants and was chronic in 116 (68.2%). A chronic course was associated with COVID-19-related hospitalization, new-onset fatigue, lower cognitive performance, motor and thermal sensory deficits, mood and sleep impairments and overall lower quality-of-life levels. Probable NP occurred in only 7.6% new-onset pain patients, and was associated with pain chronification, new-onset fatigue, motor and thermal sensory deficits, mechanical allodynia and lower rates of SARS-CoV-2 vaccination. Previous CP was reported by 86 (38.1%) individuals and had aggravated after the infection in 66 (76.7%) of them, which was associated with orthostatic hypotension. Conclusions: Post-COVID pain phenomena follow different paths, which are associated with specific clinical and epidemiological features, and possibly distinct underlying mechanisms, prognostic and therapeutic implications. Significance: COVID-19-related pain usually follows a chronic course and is non-neuropathic. Its possible courses and phenotypes are associated with distinct

show abstract

Section: Discussionmentioning

confidence: 99%

Pain paths among post‐COVID‐19 condition subjects: A prospective cross‐sectional study with in‐person evaluation

Kubota

Soares

Fonseca

et al. 2023

European Journal of Pain

View full text Add to dashboard Cite

show abstract

“…While studies have been conducted to investigate neuropathic pain during the acute phase of COVID-19 infection, the frequency and characteristics of this pain in the long term have only been investigated in a limited number of studies [25,26]. A study showed that 24.6% of new COVID-19 patients report chronic neuropathic pain after 6 months of infection [27].…”

Section: Neuropathic Pain Symptommentioning

confidence: 99%

Beyond the acute: pain in long COVID survivors at 1.5 years

Oguz-Akarsu,

Gullu,

Kilic

et al. 2024

Neurol Sci

View full text Add to dashboard Cite

Objective Long COVID, characterized by persistent symptoms post-acute COVID-19, remains a subject of intense investigation. This study focuses on pain, a common and notable symptom reported by long COVID patients. Method A cohort of 191 individuals, initially diagnosed with mild-to-moderate COVID-19, was followed up 1.5 years later to assess the frequency, clinical characteristics, and factors associated with pain persistence. Results Our study revealed that 31.9% of participants experienced at least one persistent pain symptom after 1.5 years. Headache emerged as the most prevalent symptom (29.8%), followed by myalgia (5.8%) and neuropathic pain (4.2%). Factors such as female gender and the presence of neuropathic pain symptom were identified as predictors of long-term headaches. Myalgia, showed associations with headache, arthralgia, and low ferritin levels. Persistent neuropathic pain symptom (4.2%) was linked to older age, female gender, sore throat, and headache. Conclusion This study provides insights into the evolution of pain symptoms over time after COVID-19 infection, emphasizing the interconnection between different pain syndromes. This research contributes to understanding the diverse and evolving nature of pain in long COVID survivors, offering valuable insights for targeted interventions and further investigations into the underlying mechanisms of persistent pain.

show abstract

“…A recent meta-analysis estimated that the frequency of post-COVID neuropathic pain ranged between 0.4 and 25% [ 81 ] . Another study reported the prevalence of “de novo” post-COVID neuropathic pain in almost 25% of previously hospitalized COVID-19 survivors.…”

Section: Prevalence Of Post-covid-19 Painmentioning

confidence: 99%