A systematic review and meta-analysis of effect of vitamin D levels on the incidence of COVID-19

Szarpak, Luiza; Rafique, Zubaid; Chirico, Francesco; Gawel, Wladyslaw; Hernik, Jacek; Kamińska, Halla; Filipiak‬, Krzysztof J.; Jaguszewski, Miłosz; Szarpak, Łukasz

doi:10.5603/cj.a2021.0072

Cited by 46 publications

(45 citation statements)

References 54 publications

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“…Vitamin D3 metabolism was predicted to be down-regulated in one dataset by GIMME models, and in all by tINIT models. This is in line with several meta-analyses of published data, which found significantly lower 25(OH)D concentration, and significant relation between the low concentration and infection, severity or mortality of COVID-19 patients [ [61] , [62] , [63] , [64] , [65] , [66] ]. Vitamin D3 supplementation has been hypothesised to affect clinical outcomes in patients with COVID-19, however; this was not successfully confirmed [ 61 , 67 ].…”

Section: Discussionsupporting

confidence: 90%

Integration of omics data to generate and analyse COVID-19 specific genome-scale metabolic models

Režen

Martins

Mraz

et al. 2022

Computers in Biology and Medicine

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Section: Discussionsupporting

confidence: 90%

Integration of omics data to generate and analyse COVID-19 specific genome-scale metabolic models

Režen

Martins

Mraz

et al. 2022

Computers in Biology and Medicine

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“…Although most heated discussions revolve around vitamin D, other dietary supplements have also been administrated by clinicians in an off-label basis, thanks to their broad role in immune system function and minimal adverse effect burden. Vitamin C [ 41 ] and zinc [ 42 ] offered no benefit regarding disease outcomes. Vitamin B12, which was co-administered with vitamin D and magnesium in one of our included studies, might facilitate symptom alleviation in COVID-19 [ 43 ].…”

Section: Discussionmentioning

confidence: 99%

“…As far as COVID-19 is concerned, vitamin D status is regularly proven to attain a prognostic value in large recent meta-analyses. Lower vitamin D levels are measured in COVID-19 patients than in healthy individuals [ 42 , 48 ], indicating a possible link with susceptibility to infection. Indeed, vitamin D deficiency increased the odds of contracting SARS-CoV-2 by 80% [ 49 ].…”

Section: Discussionmentioning

confidence: 99%

Therapeutic Vitamin D Supplementation Following COVID-19 Diagnosis: Where Do We Stand?—A Systematic Review

Bania

Pitsikakis

Mavrovounis

et al. 2022

JPM

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Vitamin D has known immunomodulatory activity and multiple indications exist supporting its potential use against SARS-CoV-2 infection in the setting of the current pandemic. The purpose of this systematic review is to examine the efficacy of vitamin D administered to adult patients following COVID-19 diagnosis in terms of length of hospital stay, intubation, ICU admission and mortality rates. Therefore, PubMed and Scopus databases were searched for original articles referring to the aforementioned parameters. Of the 1376 identified studies, eleven were finally included. Vitamin D supplements, and especially calcifediol, were shown to be useful in significantly reducing ICU admissions and/or mortality in four of the studies, but not in diminishing the duration of hospitalization of COVID-19 patients. Due to the large variation in vitamin D supplementation schemes no absolute conclusions can be drawn until larger randomized controlled trials are completed. However, calcifediol administered to COVID-19 patients upon diagnosis represents by far the most promising agent and should be the focus of upcoming research efforts.

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“…Therefore, its use has been proposed in the initial phase of SARS-CoV-2 associated pandemic, since March 2020, with preventive or therapeutic purpose in patients with COVID-19 at higher risk of developing severe forms of diseases, such as aged people or immunocompromised individuals ( Fiorino et al, 2020 , 2021a ). Several meta-analyses have confirmed these preliminary suggestions and have reported that individuals with vitamin D deficiency are at higher risk of SARS-CoV-2 infections and of a poorer clinical outcome in comparison with subjects with normal levels of this micronutrient ( Kaya et al, 2021 ; Ghasemian et al, 2021 ; Szarpak et al, 2021 ; Oscanoa et al, 2021 ), whereas only a few studies have examined the effects of vitamin D supplementation in patients suffering from COVID-19. Although these investigations have shown interesting results, the number of enrolled individuals is small.…”

Section: Discussionmentioning

confidence: 91%

Effects of environmental parameters and their interactions on the spreading of SARS-CoV-2 in North Italy under different social restrictions. A new approach based on multivariate analysis

Tateo

Fiorino

Peruzzo

et al. 2022

Environmental Research

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In 2020 North Italy suffered the SARS-CoV-2-related pandemic with a high number of deaths and hospitalization. The effect of atmospheric parameters on the amount of hospital admissions (temperature, solar radiation, particulate matter, relative humidity and wind speed) is studied through about 8 months (May–December). Two periods are considered depending on different conditions: a) low incidence of COVID-19 and very few regulations concerning personal mobility and protection (“free/summer period”); b) increasing incidence of disease, social restrictions and use of personal protections (“confined/autumn period”). The “hospitalized people in medical area wards/100000 residents” was used as a reliable measure of COVID-19 spreading and load on the sanitary system. We developed a chemometric approach (multiple linear regression analysis) using the daily incidence of hospitalizations as a function of the single independent variables and of their products (interactions). Eight administrative domains were considered (altogether 26 million inhabitants) to account for relatively homogeneous territorial and social conditions. The obtained models very significantly match the daily variation of hospitalizations, during the two periods. Under the confined/autumn period, the effect of non-pharmacologic measures (social distances, personal protection, etc.) possibly attenuates the virus diffusion despite environmental factors. On the contrary, in the free/summer conditions the effects of atmospheric parameters are very significant through all the areas. Particulate matter matches the growth of hospitalizations in areas with low chronic particulate pollution. Fewer hospitalizations strongly correspond to higher temperature and solar radiation. Relative humidity plays the same role, but with a lesser extent. The interaction between solar radiation and high temperature is also highly significant and represents surprising evidence. The solar radiation alone and combined with high temperature exert an anti-SARS-CoV-2 effect, via both the direct inactivation of virions and the stimulation of vitamin D synthesis, improving immune system function.

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A systematic review and meta-analysis of effect of vitamin D levels on the incidence of COVID-19

Cited by 46 publications

References 54 publications

Integration of omics data to generate and analyse COVID-19 specific genome-scale metabolic models

Integration of omics data to generate and analyse COVID-19 specific genome-scale metabolic models

Therapeutic Vitamin D Supplementation Following COVID-19 Diagnosis: Where Do We Stand?—A Systematic Review

Effects of environmental parameters and their interactions on the spreading of SARS-CoV-2 in North Italy under different social restrictions. A new approach based on multivariate analysis

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