2017
DOI: 10.1093/ageing/afx086
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A systematic review and meta-analysis of prospective associations between alcohol consumption and incident frailty

Abstract: this systematic review and meta-analysis study provides the first pooled evidence suggesting that heavier alcohol consumption is associated with lower incident frailty compared with no alcohol consumption among community-dwelling middle-aged and older people. However, this association may be due to unadjusted effect measures, residual confounding, 'sick quitter' effect or survival bias.

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Cited by 73 publications
(69 citation statements)
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References 28 publications
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“…Similarly, initiating alcohol use appeared protective, but the effect was similarly confounded. This study is among the first to demonstrate relationships between discontinuation and initiation of alcohol use and long-term mortality in any population and supports the hypothesis that changes in this behavior might be related to mortality through noncausal mechanisms (24,25).…”
Section: Discussionsupporting
confidence: 76%
See 1 more Smart Citation
“…Similarly, initiating alcohol use appeared protective, but the effect was similarly confounded. This study is among the first to demonstrate relationships between discontinuation and initiation of alcohol use and long-term mortality in any population and supports the hypothesis that changes in this behavior might be related to mortality through noncausal mechanisms (24,25).…”
Section: Discussionsupporting
confidence: 76%
“…Studies in the general population have observed lower risks of frailty and death among those who drink alcohol (16,24,26). However, reduced risks of death were not observed among younger individuals who drink alcohol, suggesting that changes in this behavior over time occurring with illness and aging, as well as selection bias, may result in residual confounding in these cohort studies (25,(27)(28)(29)(30).…”
Section: Discussionmentioning
confidence: 78%
“…data of the heaviest drinkers were used in the main metaanalysis and the association of intermediate alcohol use categories with incident frailty has not been investigated (2). Therefore, to further explore potential linear and non-linear associations between alcohol consumption and incident frailty risk, we conducted a two-stage doseresponse meta-analysis using the data from the same longitudinal cohort studies.…”
mentioning
confidence: 99%
“…The data used come from three prospective studies examining associations between quantity of alcohol consumption and incident frailty (4)(5)(6), identified in our previous systematic review and meta-analysis study, that provided data on frailty risk according to quantity of alcohol consumption (2). A value (in grams of alcohol per day) assigned to each alcohol consumption category was based on a mid-point of the upper and lower boundary values of the category.…”
mentioning
confidence: 99%
“…Опубликованный в 2018 г. систематический обзор и метаанализ Kojima et al показал, что прием ≥24 г в день этанола мужчинами и ≥12 г в день женщинами 55 лет и старше достоверно снижает частоту эпизодов слабости [79].…”
Section: остеопороз жкб деменция…unclassified