A systematic review and meta-analysis of the effect of depot antipsychotic frequency on compliance and outcome

Kisely, Steve; Sawyer, Emily; Robinson, Gail; Siskind, Dan

doi:10.1016/j.schres.2015.04.028

Cited by 12 publications

(12 citation statements)

References 40 publications

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“…In contrast, and in support of the hypothesis, the intermittently-treated RISP groups did not differ from the VEH-treated control group, suggesting that spontaneous recovery after cortical impact injury was not impeded. Clinically, the data on dosing frequency of APDs is scarce, but Kisely and colleagues (2015) found no differences in psychotic symptoms or quality of life between two and four weekly doses of the APDs olanzapine, RISP, haloperidol, and fluphenazine [31]. This finding corresponds with the current study, and lends support for effective and safe intermittent administration paradigms.…”

Section: Discussionsupporting

confidence: 85%

Spontaneous recovery after controlled cortical impact injury is not impeded by intermittent administration of the antipsychotic drug risperidone

Carlson

Bao

Besagar

et al. 2018

Neuroscience Letters

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Several preclinical studies have reported that daily administration of the antipsychotic drug (APD) risperidone (RISP) impedes recovery after traumatic brain injury (TBI). However, it is not known whether intermittent dosing would produce similar deleterious effects. The relevance of providing APDs intermittently is that not all patients in rehabilitation require daily treatments to manage TBI-induced agitation. Hence, the goal of the current study was to test the hypothesis that intermittent (vs. daily) administration of RISP would be less disturbing to motor and cognitive recovery after TBI. Anesthetized adult male rats were subjected to either a cortical impact of moderate severity or sham injury and then were randomly assigned to groups receiving intraperitoneal injections of vehicle (VEH; 1.0 mL/kg) or RISP (0.45 mg/kg) 1x, 3x, or 7x per week until the completion of behavioral testing, which consisted of motor and cognitive assessments on post-operative days 1-5 and 14-19, respectively. The group receiving RISP 7x week exhibited greater motor and cognitive impairment compared to those receiving RISP 1x or 3x per week, or VEH [p<0.05]. Moreover, no differences were observed between the intermittent RISP groups vs. VEH [p>0.05], which supports the hypothesis. A potential clinical ramification is that RISP may be safe to manage agitation after TBI, but only when used sparingly.

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Section: Discussionsupporting

confidence: 85%

Spontaneous recovery after controlled cortical impact injury is not impeded by intermittent administration of the antipsychotic drug risperidone

Carlson

Bao

Besagar

et al. 2018

Neuroscience Letters

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“…Depot antipsychotics are generally preferred in patients who are not expected to adhere strictly to their treatment. Lack of insight and poor cognitive function are central to poor treatment adherence in schizophrenia [43]. …”

Section: Discussionmentioning

confidence: 99%

Antipsychotic Use Pattern in Schizophrenia Outpatients: Correlates of Polypharmacy

Yazıcı

Çilli

Yazıcı

et al. 2017

CPEMH

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Background:This study investigates the antipsychotic use patterns of patients with schizophrenia and its correlations in their daily drug use patterns.Methods:Patients with schizophrenia who have regular records at two different community counselling centres (CCS) were included in the study. Information about their medications and sociodemographic data was recorded through face-to-face interviews and supporting information about their drug use patterns was obtained from their relatives/caregivers/nurse. The Clinical Global Impression Scale (severity of illness) and the General Assessment of Functionality scales were also administered.Results:Patients with schizophrenia used 2.0 ± 0.81 antipsychotics daily and 3.52 ± 2.55 pills (1–18). Seventy-one percent of the patients used two or more kinds of psychotropic drugs. The most frequently used antipsychotics were quetiapine, a second generation antipsychotic, and haloperidol, a typical antipsychotic. Clinical severity, regular visits to a CCS and use of depot antipsychotics were independent predictors for polypharmacy.Conclusion:The rate of polypharmacy use is high in Turkey. There are multiple risk factors related with polipharmacy. New studies should focus risk factors for preventing polypharmacy.

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“…2 However, the influence of factors that might affect outcome, such as optimal dosing interval, remain to be fully investigated. 3 Risperidone was the first of the newer, atypical antipsychotics to be formulated as a long-acting injection. Due to its pharmacokinetic properties, risperidone long-acting injection (RLAI) must be administered on a fortnightly basis.…”

Section: Introductionmentioning

confidence: 99%

Effectiveness of paliperidone long-acting injection in clinical practice

Deslandes

Ward

Norris

et al. 2018

Therapeutic Advances in Psychopharmacology

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A systematic review and meta-analysis of the effect of depot antipsychotic frequency on compliance and outcome

Cited by 12 publications

References 40 publications

Spontaneous recovery after controlled cortical impact injury is not impeded by intermittent administration of the antipsychotic drug risperidone

Spontaneous recovery after controlled cortical impact injury is not impeded by intermittent administration of the antipsychotic drug risperidone

Antipsychotic Use Pattern in Schizophrenia Outpatients: Correlates of Polypharmacy

Effectiveness of paliperidone long-acting injection in clinical practice

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