A systematic review and meta-analysis of mortality in chronic Chagas cardiomyopathy versus other cardiomyopathies: higher risk or fiction?

Gómez-Ochoa, Sergio A.; Serrano-García, Angie Yarlady; Hurtado-Ortiz, Alexandra; Aceros, Andrea; Rojas, Lyda Z.; Echeverría, Luis E.

doi:10.1016/j.rec.2024.02.014

Revista Española de Cardiología (English Edition)

2024

DOI: 10.1016/j.rec.2024.02.014

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A systematic review and meta-analysis of mortality in chronic Chagas cardiomyopathy versus other cardiomyopathies: higher risk or fiction?

Sergio A. Gómez-Ochoa,

Angie Yarlady Serrano-García,

Alexandra Hurtado-Ortiz

et al.

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2024

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Mechanisms behind the high mortality rate in chronic Chagas cardiomyopathy: Unmasking a three‐headed monster

Echeverría,

Serrano‐García,

Rojas

et al. 2024

European J of Heart Fail

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Chagas disease is a neglected tropical disease caused by the parasite Trypanosoma cruzi. Chronic Chagas cardiomyopathy (CCC), the most severe form of target organ involvement in Chagas disease, is characterized by a complex pathophysiology and a unique phenotype that differentiates it from other cardiomyopathies, highlighting its worse prognosis compared to other aetiologies of heart failure. The three pathophysiological mechanisms with the largest impact on this differential mortality include rapidly progressive heart failure, a high incidence of stroke, and a high burden of ventricular arrhythmias. However, despite significant advances in understanding the unique molecular circuits underlying these mechanisms, the new knowledge acquired has not been efficiently translated into specific diagnostic and therapeutic approaches for this unique cardiomyopathy. The lack of dedicated clinical trials and the limited CCC‐specific risk stratification tools available are evidence of this reality. This review aims to provide an updated perspective of the evidence and pathophysiological mechanisms associated with the higher mortality observed in CCC compared to other cardiomyopathies and highlight opportunities in the diagnostic and therapeutic approaches of the disease.

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Mechanisms behind the high mortality rate in chronic Chagas cardiomyopathy: Unmasking a three‐headed monster

Echeverría,

Serrano‐García,

Rojas

et al. 2024

European J of Heart Fail

View full text Add to dashboard Cite

show abstract

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A systematic review and meta-analysis of mortality in chronic Chagas cardiomyopathy versus other cardiomyopathies: higher risk or fiction?

Cited by 1 publication

References 50 publications

Mechanisms behind the high mortality rate in chronic Chagas cardiomyopathy: Unmasking a three‐headed monster

Mechanisms behind the high mortality rate in chronic Chagas cardiomyopathy: Unmasking a three‐headed monster

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