A systematic review and meta-analysis of the n-3 polyunsaturated fatty acids effects on inflammatory markers in colorectal cancer

Mocellin, Michel Carlos; Camargo, Carolina de Quadros; Nunes, Everson Araújo; Fiates, Giovanna Medeiros Rataichesck; Trindade, Erasmo B. S. M.

doi:10.1016/j.clnu.2015.04.013

Cited by 99 publications

(60 citation statements)

References 34 publications

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“…However, the results achieved in a recent meta-analysis carried out to evaluate the effects of ω3 PUFA on inflammatory markers in CRC patients highlighted that the beneficial effects of ω3 PUFA rely on supplementation protocols (e.g., dose, duration, and route of administration), the concomitant anticancer regimen adopted, as well as on the confounding effects due to other nutrients that might be present in the supplement (26). In this regard, it should be taken into account that the observational studies carried out to evaluate the potential anticancer effects of ω3 PUFA might have been limited by the insufficient homogeneity of the observations.…”

Section: Dietary Polyunsaturated Fatty Acidsmentioning

confidence: 99%

“…In this regard, it should be taken into account that the observational studies carried out to evaluate the potential anticancer effects of ω3 PUFA might have been limited by the insufficient homogeneity of the observations. An explanation for such heterogeneity relies likely on the inherent difficulties associated with epidemiology, including the confounding and dietary pattern context, measurement error, level of intake, and genetic polymorphisms (26, 27). …”

Section: Dietary Polyunsaturated Fatty Acidsmentioning

confidence: 99%

“…Pro-inflammatory cytokines and tumor-infiltrating myeloid and immune cells play critical roles in almost every developmental stages of inflammation-related cancers, from initiation, promotion, and progression to malignant metastasis (1). A recently published meta-analysis of the ω3 PUFA effects on inflammatory markers highlighted a decreased level of some inflammatory mediators (cytokines or acute phase proteins) in CRC patients who received ω3 PUFA supplementation (26). Likewise, a recent in vitro study described a new anti-inflammatory and anticancer properties of DHA.…”

Section: Protective Anti-inflammatory Effects Of ω3 Pufa In Colorectamentioning

confidence: 99%

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ω3 Polyunsaturated Fatty Acids as Immunomodulators in Colorectal Cancer: New Potential Role in Adjuvant Therapies

Miccadei¹,

Masella

Mileo³

et al. 2016

Front. Immunol.

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Diet composition may affect the onset and progression of chronic degenerative diseases, including cancer, whose pathogenesis relies on inflammatory processes. Growing evidence indicates that diet and its components critically contribute to human health, affecting the immune system, secretion of adipokines, and metabolic pathways. Colorectal cancer (CRC) is one of the leading causes of death worldwide. Antineoplastic drugs are widely used for CRC treatment, but drug resistance and/or off-target toxicity limit their efficacy. Dietary ω3 polyunsaturated fatty acids (PUFA) have been gaining great interest in recent years as possible anti-inflammatory and anticancer agents, especially in areas such as the large bowel, where the pro-inflammatory context promotes virtually all steps of colon carcinogenesis. Growing epidemiological, experimental, and clinical evidence suggests that ω3 PUFA may play a role in several stages of CRC management exhibiting antineoplastic activity against human CRC cells, improving the efficacy of radiation and chemotherapy, ameliorating cancer-associated secondary complications, and preventing CRC recurrence. These effects are most likely related to the immunomodulatory activities of ω3 PUFA that are able to influence several aspects of the inflammatory process ranging from inflammasome activation, leukocyte recruitment, production of immune mediators to differentiation, and activation of immune cells. In this review, we will focus on the potential use of ω3 PUFA as adjuvant agents together with chemo/radiotherapy, highlighting the immunomodulatory effects most likely responsible for their beneficial effects in different stages of CRC management.

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Section: Dietary Polyunsaturated Fatty Acidsmentioning

confidence: 99%

Section: Dietary Polyunsaturated Fatty Acidsmentioning

confidence: 99%

Section: Protective Anti-inflammatory Effects Of ω3 Pufa In Colorectamentioning

confidence: 99%

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ω3 Polyunsaturated Fatty Acids as Immunomodulators in Colorectal Cancer: New Potential Role in Adjuvant Therapies

Miccadei¹,

Masella

Mileo³

et al. 2016

Front. Immunol.

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“…The results from a metaanalysis by Mocellin et al (2015) supported n-3 PUFA supplementation as a way to diminish the inflammatory state in CRC patients, either by decreasing levels of IL-6 or CRP/albumin ratio. Moreover, Silva et al (2012) showed that fish oil supplementation (2 g of fish oil, 600 mg/day EPA + DHA) prevented weight loss in patients undergoing chemotherapy, which may influence their quality of life and overall wellbeing.…”

Section: Pufas In Colorectal Cancermentioning

confidence: 98%

Polyunsaturated Fatty Acids and Their Derivatives: Therapeutic Value for Inflammatory, Functional Gastrointestinal Disorders, and Colorectal Cancer

2016

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Polyunsaturated fatty acids (PUFAs) are bioactive lipids which modulate inflammation and immunity. They gained recognition in nutritional therapy and are recommended dietary supplements. There is a growing body of evidence suggesting the usefulness of PUFAs in active therapy of various gastrointestinal (GI) diseases. In this review we briefly cover the systematics of PUFAs and their metabolites, and elaborate on their possible use in inflammatory bowel disease (IBD), functional gastrointestinal disorders (FGIDs) with focus on irritable bowel syndrome (IBS), and colorectal cancer (CRC). Each section describes the latest findings from in vitro and in vivo studies, with reports of clinical interventions when available.

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“…Their use, especially by parenteral route, diminishes several inflammatory biomarkers in both acutely and chronically ill patients (4). They also reduce interleukin-6, increase albumin and, additionally, decrease the C-reactive protein to albumin ratio in colorectal cancer patients (5).…”

Section: Introductionmentioning

confidence: 99%

Effects unrelated to anti-inflammation of lipid emulsions containing fish oil in parenteral nutrition for adult patients

Joaquín¹,

Florit-Sureda²

2017

Nutr Hosp

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Mateu-de-Antonio J, Florit-Sureda M. Effects unrelated to anti-infl ammation of lipid emulsions containing fi sh oil in parenteral nutrition for adult patients. Nutr Hosp 2017;34:193-203 ResumenSe han publicado varias revisiones y metaanálisis sobre la modulación de las respuestas infl amatorias e inmunológicas por la administración de ácidos grasos poliinsaturados (AGPI) omega-3. Sin embargo, los AGPI omega-3 ejercen otras acciones no directamente relacionadas con estas respuestas. El objetivo de este trabajo es revisar los efectos de las emulsiones lipídicas intravenosas (ELIV) que contienen aceite de pescado (AP) en la nutrición parenteral (NP) de pacientes adultos. Estas emulsiones pueden tener un papel importante en la prevención de las alteraciones del perfi l hepático o de la enfermedad hepática asociada a la NP (EHANP) en comparación con las ELIV sin AP. Los estudios que usaron dosis ≥ 0,150 mg/kg/día presentaron resultados más positivos que aquellos con dosis menores. Una vez se ha presentado la EHANP, el uso de una ELIV compuesta exclusivamente de AP, a dosis de 0,25-1 g de AP/kg/día durante varias semanas, podría atenuar o incluso revertir la alteración hepática y la colestasis cuando la administración de la NP es crónica. Las ELIV con AP parecen tener un aclaramiento plasmático más rápido, lo que podría suponer una ventaja en ciertos pacientes. Algunos estudios también sugieren que estas emulsiones podrían mejorar la función respiratoria. En general, estas ELIV que contienen AP son muy seguras, no aumentan el estrés oxidativo e incluso incrementan el nivel de alfa-tocoferol plasmático. Asimismo, no alteran la sensibilidad a la insulina o el control glicémico y tampoco se ha demostrado que afecten clínicamente a la agregación plaquetaria o a la hemostasia. En conclusión, el uso de ELIV con AP en la NP podría suponer algunas ventajas frente a la ELIV sin AP, además de la modulación de la respuesta infl amatoria sistémica. AbstractSeveral reviews and meta-analyses on modulated infl ammatory and immunologic responses after the administration of omega-3 polyunsaturated fatty acids (PUFAs) in different diseases and conditions have been published. However, omega-3 PUFAs exert several other actions which are not directly related to immunologic or infl ammatory responses. The aim of this paper was to review the effects which are not directly related to immunologic and infl ammatory responses of intravenous lipid emulsions (IVLEs) containing fi sh oil (FO) in parenteral nutrition (PN) for adult patients. IVLEs containing FO could have a role in the prevention of alterations in liver enzyme tests (LETs) or PN-associated liver disease (PNALD). Studies using FO doses of ≥ 0.150 mg/kg/day or IVLEs with high FO concentration reported more positive results than those with lower doses. Once PNALD was developed, the use of IVLEs exclusively composed of FO at doses of 0.25-1 g of FO/kg/day for several weeks could attenuate or even eradicate cholestasis and liver alteration. IVLEs containing FO seemed to have faster...

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A systematic review and meta-analysis of the n-3 polyunsaturated fatty acids effects on inflammatory markers in colorectal cancer

Cited by 99 publications

References 34 publications

ω3 Polyunsaturated Fatty Acids as Immunomodulators in Colorectal Cancer: New Potential Role in Adjuvant Therapies

ω3 Polyunsaturated Fatty Acids as Immunomodulators in Colorectal Cancer: New Potential Role in Adjuvant Therapies

Polyunsaturated Fatty Acids and Their Derivatives: Therapeutic Value for Inflammatory, Functional Gastrointestinal Disorders, and Colorectal Cancer

Effects unrelated to anti-inflammation of lipid emulsions containing fish oil in parenteral nutrition for adult patients

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